Nitric oxide-loaded chitosan nanoparticles as an innovative antileishmanial platform
Publication date: Available online 18 September 2019Source: Nitric OxideAuthor(s): Fernanda V. Cabral, Milena T. Pelegrino, Ismael P. Sauter, Amedea B. Seabra, Mauro Cortez, Martha S. RibeiroAbstractLeishmaniasis is a neglected tropical disease that demands for new therapeutic strategies due to adverse side effects and resistance development promoted by current drugs. Nitric oxide (NO)-donors show potential to kill Leishmania spp. but their use is limited because of their instability. In this work, we synthesize, characterize, and encapsulate S-nitroso-mercaptosuccinic acid into chitosan nanoparticles (NONPs) and investiga...
Source: Nitric Oxide - September 19, 2019 Category: Chemistry Source Type: research
Nitric oxide stimulates a PKC-Src-Akt signaling axis which increases human immunodeficiency virus type 1 replication in human T lymphocytes
In conclusion, oxidative/nitrosative stress conditions derived from exposure of HIV-1-infected CD4+T lymphocytes to an exogenous NO source trigger a signaling cascade involving PKC, Src kinase and Akt. Activation of this signaling cascade appears to be critical to the establishment of HIV-1 infection.Graphical abstract (Source: Nitric Oxide)
Source: Nitric Oxide - September 18, 2019 Category: Chemistry Source Type: research
Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
In conclusion, our data show that ADMA accumulation-mediated decrease in NO production plays an important role in cardiomyocyte remodeling, which may be associated with ILF3-mediated DDAH1 reduction. (Source: Nitric Oxide)
Source: Nitric Oxide - September 18, 2019 Category: Chemistry Source Type: research
Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest
ConclusionsNitrite, administered early after ROSC from VF, was shown to cross the blood brain barrier after a 5 min VF cardiac arrest. We characterized the PK of intravenous nitrite administration after VF and were able to demonstrate nitrite safety in this feasibility study. (Source: Nitric Oxide)
Source: Nitric Oxide - September 14, 2019 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 November 2019Source: Nitric Oxide, Volume 92Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - September 11, 2019 Category: Chemistry Source Type: research
Pharmacokinetics and pharmacodynamics of single dose of inhaled nebulized sodium nitrite in healthy and hemoglobin E/β-thalassemia subjects
This study investigated the pharmacokinetics and pharmacodynamics of inhaled nebulized sodium nitrite in 10 healthy subjects and 8 HbE/β-thal patients with high estimated pulmonary artery pressure. Nitrite pharmacokinetics, fraction exhaled nitric oxide (FENO), estimated right ventricular systolic pressure (eRVSP) measured by echocardiography, and platelet activation were determined. Nebulized sodium nitrite at doses used in this study (37.5 and 75 mg for healthy subjects and 15 mg for HbE/β-thal patients) was well tolerated and did not cause changes in methemoglobin levels and systemic blood pressure. Absorption of ...
Source: Nitric Oxide - September 10, 2019 Category: Chemistry Source Type: research
Comprehensive study of nitrofuroxanoquinolines. New perspective donors of NO molecules
Publication date: Available online 6 September 2019Source: Nitric OxideAuthor(s): Nikita S. Fedik, Mikhail E. Kletskii, Oleg N. Burov, Anton V. Lisovin, Sergey V. Kurbatov, Vladimir A. Chistyakov, Pavel G. MorozovAbstractThe goal of present work is the study of NO releasing mechanisms in nitrofuroxanoquinoline (NFQ) derivatives. Mechanisms of their structural non-rigidity and pathways of NO donation - spontaneous or under the action of sulfanyl radicals or photoirradiation - were considered in details, both experimentally and quantum chemically. Furoxan-containing systems of the discussed type are not capable of spontaneou...
Source: Nitric Oxide - September 7, 2019 Category: Chemistry Source Type: research
Hydrogen sulfide potentiates the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats
ConclusionLow dose of NaSH per se had no effect on carbohydrate metabolism while it potentiated the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats. These favorable effects were associated with decreased oxidative stress and increased GLUT4 expression in insulin-sensitive tissues as well as improvement of liver function.Graphical abstract (Source: Nitric Oxide)
Source: Nitric Oxide - September 1, 2019 Category: Chemistry Source Type: research
Valproic acid promotes mature neuronal differentiation of adipose tissue-derived stem cells through iNOS–NO–cGMP signaling pathway
Publication date: Available online 1 September 2019Source: Nitric OxideAuthor(s): Takumi Okubo, Shinri Fujimoto, Daiki Hayashi, Takehito Suzuki, Motoharu Sakaue, Yoko Miyazaki, Kazuaki Tanaka, Makoto Usami, Tatsuya TakizawaAbstractValproic acid (VPA) remarkably promotes the differentiation of adipose tissue-derived stem cells (ASCs) to mature neuronal cells, enabling neuronal induction within only three days. Here, we investigated the involvement of NO-signaling in the VPA-promoted neuronal differentiation of ASCs as a possible mechanism. Cultured rat ASCs were differentiated to matured neuronal cells rich in dendrites and...
Source: Nitric Oxide - September 1, 2019 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 October 2019Source: Nitric Oxide, Volume 91Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - August 17, 2019 Category: Chemistry Source Type: research
Sensitive and quantitative method to evaluate DNA methylation of the positive regulatory domains (PRDI, PRDII) and cAMP response element (CRE) in human endothelial nitric oxide synthase promoter
Publication date: Available online 14 August 2019Source: Nitric OxideAuthor(s): V. Vigorelli, E. Rurali, S. Carugo, G. Pompilio, Mc VinciAbstractNitric oxide plays a prominent role in the cardiovascular system and much attention has been devoted in the last years on deciphering the regulation of human endothelial nitric oxide synthase (eNOS) expression. Epigenetic-based mechanisms have a key role in the eNOS expression and their pathologic perturbations may have profound effects on the steady state RNA levels in the endothelium. The human eNOS promoter lacks a canonical TATA box and it does not contain a proximal CpG islan...
Source: Nitric Oxide - August 15, 2019 Category: Chemistry Source Type: research
The effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway
In conclusion, PEMF generate analgesia by activating the NO pain pathway. (Source: Nitric Oxide)
Source: Nitric Oxide - August 12, 2019 Category: Chemistry Source Type: research
Nasal nitric oxide in relation to psychiatric status of patients with empty nose syndrome
ConclusionsnNO significantly increased at third month after surgical treatment and remained plateaued in ENS patients. This increase correlated with improvements in BDI-II and BAI scores. Therefore, nNO may be important in assessing the psychiatric status of empty nose syndrome. (Source: Nitric Oxide)
Source: Nitric Oxide - August 11, 2019 Category: Chemistry Source Type: research
Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics
Publication date: Available online 8 August 2019Source: Nitric OxideAuthor(s): Turtushikh Damba, Mengfan Zhang, Manon Buist-Homan, Harry van Goor, Klaas Nico Faber, Han MoshageAbstractHepatic fibrosis is caused by chronic inflammation and characterized as the excessive accumulation of extracellular matrix (ECM) by activated hepatic stellate cells (HSCs). Gasotransmitters like NO and CO are known to modulate inflammation and fibrosis, however, little is known about the role of the gasotransmitter hydrogen sulfide (H2S) in liver fibrogenesis and stellate cell activation. Endogenous H2S is produced by the enzymes cystathionin...
Source: Nitric Oxide - August 10, 2019 Category: Chemistry Source Type: research
Differential effects of resveratrol on the dilator responses of femoral arteries, ex vivo
Publication date: 1 November 2019Source: Nitric Oxide, Volume 92Author(s): Miguel Diaz, Vijay Parikh, Saira Ismail, Raja Maxamed, Emily Tye, Clare Austin, Tristan Dew, Brigitte A. Graf, Luc Vanhees, Hans Degens, May AzzawiAbstractResveratrol is a plant-derived phytoalexin with antioxidant, anti-inflammatory and cardio-protective properties and may be a promising therapeutic intervention strategy in cardiovascular disease. Here, we investigated the acute direct effects of trans-resveratrol (RV), on acetylcholine (ACh)-induced and flow-mediated dilation (FMD) of isolated pressurized femoral arteries of young (4-month-old) an...
Source: Nitric Oxide - August 10, 2019 Category: Chemistry Source Type: research
