Endothelial nitric oxide synthase enhancer AVE3085 reverses endothelial dysfunction induced by homocysteine in human internal mammary arteries
Publication date: Available online 6 October 2018Source: Nitric OxideAuthor(s): Hai-Tao Hou, Jun Wang, Xi Zhang, Zheng-Qing Wang, Tie-Nan Chen, Jian-Liang Zhang, Qin Yang, Guo-Wei HeAbstractHomocysteine (Hcy) is an independent risk factor for endothelial dysfunction in cardiovascular diseases. We hypothesized that the eNOS transcription enhancer AVE3085 may protect the endothelial function damaged by Hcy in the human internal mammary artery (IMA). Cumulative concentration-relaxation curves to acetylcholine (−10 to −4.5 log mol/L) or sodium nitroprusside were established in IMA from patients undergoing coronary artery s...
Source: Nitric Oxide - October 7, 2018 Category: Chemistry Source Type: research
Proteomics analysis reveals that nitric oxide regulates photosynthesis of maize seedlings under water deficiency
In this study, treatment with 0.1 mM NO donor (sodium nitroprusside, SNP) significantly alleviated the inhibited growth induced by 15% polyethyleneglycol (PEG)-stimulated water deficiency (WD) for 3 days in maize seedlings, manifested by less decreased plant total fresh weight and dry weight. Comprehensive proteome analysis was further used to measure the expression profiles of leaf proteins of SNP-pretreated maize seedlings under WD conditions to explore the molecular mechanisms of NO-induced WD tolerance. Using 2-DE method, 135 protein spots showed significantly enhanced or reduced abundance, of which 102 spots were suc...
Source: Nitric Oxide - October 6, 2018 Category: Chemistry Source Type: research
Neuronal nitric oxide synthase contributes to the normalization of blood pressure in medicated hypertensive patients
In conclusion, nNOS-derived H2O2 contributes to the endothelium-dependent vascular relaxation in human resistance mesenteric arteries. The endothelial dysfunction observed in uncontrolled hypertensive patients involves decreased eNOS expression and NO production. The normalization of vascular relaxation and blood pressure in controlled hypertensive patients involves increased nNOS-derived H2O2 and NO production. (Source: Nitric Oxide)
Source: Nitric Oxide - October 5, 2018 Category: Chemistry Source Type: research
Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats
ConclusionSO2 attenuated sepsis-induced cardiac dysfunction likely in association with the inhibiting inflammation via TLR4/NLRP3 signaling pathway. (Source: Nitric Oxide)
Source: Nitric Oxide - October 5, 2018 Category: Chemistry Source Type: research
Abscisic acid and nitric oxide modulate cytoskeleton organization, root hair growth and ectopic hair formation in Arabidopsis
Publication date: Available online 17 September 2018Source: Nitric OxideAuthor(s): María Cristina Lombardo, Lorenzo LamattinaAbstractAbscisic acid (ABA) and nitric oxide (NO) are two plant growth regulators that participate in many signaling cascades in different organs all along the plant life. Here, we were interested in deciphering the effects of ABA and NO on the cytoskeleton organization in a model of polarized cell growth like root hairs. Arabidopsis roots were exposed to different concentrations of ABA, and the length of primary root, epidermal cells and root hairs were measured. The NO concentration was detected w...
Source: Nitric Oxide - September 18, 2018 Category: Chemistry Source Type: research
Donor heart preservation with a novel long-term and slow-releasing hydrogen sulfide system
Publication date: Available online 11 September 2018Source: Nitric OxideAuthor(s): Xiaotian Sun, Wenshuo Wang, Jing Dai, Jiechun Huang, Meng Shi, Xianglin Chu, Fangrui Wang, Changfa Guo, Chunsheng Wang, Liewen Pang, Yiqing WangAbstractCardiac transplantation has been limited by the inability to long preserve donor hearts safely. Hydrogen sulfide (H2S) has been recognized as an important gasotransmitter exerting potent cardioprotection from ischemia/reperfusion injury (I/R). Herein we investigated the cardioprotective effects of a novel long-term and slow-releasing H2S system, namely DATS-MSN, in heart preservation solution...
Source: Nitric Oxide - September 12, 2018 Category: Chemistry Source Type: research
Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway
Publication date: Available online 1 September 2018Source: Nitric OxideAuthor(s): Teresa Tropea, Mark Wareing, Susan L. Greenwood, Martin Feelisch, Colin P. Sibley, Elizabeth C. CottrellAbstractAdequate perfusion of the placental vasculature is essential to meet the metabolic demands of fetal growth and development. Lacking neural control, local tissue metabolites, circulating and physical factors contribute significantly to blood flow regulation. Nitric oxide (NO) is a key regulator of fetoplacental vascular tone. Nitrite, previously considered an inert end-product of NO oxidation, has been shown to provide an important s...
Source: Nitric Oxide - September 2, 2018 Category: Chemistry Source Type: research
A high-refined carbohydrate diet facilitates compulsive-like behavior in mice through the nitric oxide pathway
ConclusionAltogether, our results suggest that the chronic consumption of a HC diet induces compulsive-like behavior through a mechanism possibly associated with NO activation in the striatum. (Source: Nitric Oxide)
Source: Nitric Oxide - August 18, 2018 Category: Chemistry Source Type: research
Inorganic nitrate supplementation enhances functional capacity and lower-limb microvascular reactivity in patients with peripheral artery disease
Publication date: Available online 15 August 2018Source: Nitric OxideAuthor(s): Joshua M. Bock, David P. Treichler, Samuel L. Norton, Kenichi Ueda, William E. Hughes, Darren P. CaseyAbstractPeripheral artery disease (PAD) is characterized by functional and vascular impairments as well as elevated levels of inflammation which are associated with reduced nitric oxide (NO) bioavailability. Inorganic nitrate supplementation boosts NO bioavailability potentially improving functional and vasodilatory capacities and may reduce inflammation. Twenty-one patients with PAD were randomly assigned to sodium nitrate (NaNO3) or placebo s...
Source: Nitric Oxide - August 15, 2018 Category: Chemistry Source Type: research
The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice
Publication date: Available online 14 August 2018Source: Nitric OxideAuthor(s): Li Wang, Luis E.F. Almeida, Sayuri Kamimura, Jack H. van der Meulen, Kanneboyina Nagaraju, Martha Quezado, Paul Wakim, Zenaide M.N. QuezadoAbstractSickle cell disease (SCD) patients can have limited exercise capacity and muscle dysfunction characterized by decreased force, atrophy, microvascular abnormalities, fiber distribution changes, and skeletal muscle energetics abnormalities. Growing evidence suggests that in SCD, there is alteration in nitric oxide (NO) availability/signaling and that nitrate/nitrite can serve as a NO reservoir and enha...
Source: Nitric Oxide - August 14, 2018 Category: Chemistry Source Type: research
Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites
ConclusionsMetabolites in blood do not reflect NO metabolite status of any organ. Although NO is rapidly inactivated by hemoglobin-mediated oxidation in the circulation, long-lived tissue metabolites may account for the myocardial preconditioning effects of inhaled NO. NO inhalation may afford similar protection in other organs. (Source: Nitric Oxide)
Source: Nitric Oxide - August 14, 2018 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 September 2018Source: Nitric Oxide, Volume 79Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - August 11, 2018 Category: Chemistry Source Type: research
Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial
Publication date: Available online 9 August 2018Source: Nitric OxideAuthor(s): Laura Ormesher, Jenny E. Myers, Catherine Chmiel, Mark Wareing, Susan L. Greenwood, Teresa Tropea, Jon O. Lundberg, Eddie Weitzberg, Carina Nihlen, Colin P. Sibley, Edward D. Johnstone, Elizabeth C. CottrellAbstractChronic hypertension in pregnancy is associated with significant adverse pregnancy outcomes, increasing the risk of pre-eclampsia, fetal growth restriction and preterm birth. Dietary nitrate, abundant in green leafy vegetables and beetroot, is reduced in vivo to nitrite and subsequently nitric oxide, and has been demonstrated to lower...
Source: Nitric Oxide - August 10, 2018 Category: Chemistry Source Type: research
Signaling interplay between primary cilia and nitric oxide: A mini review
Publication date: Available online 9 August 2018Source: Nitric OxideAuthor(s): Hannah C. Saternos, Wissam A. AbouAlaiwiAbstractNew discoveries into the functional role of primary cilia are on the rise. In little more than 20 years, research has shown the once vestigial organelle is a signaling powerhouse involved in a vast number of essential cellular processes. In the same decade that interest in primary cilia was burgeoning, nitric oxide won molecule of the year and a Nobel prize for its role as a near ubiquitous signaling molecule. Although primary cilia and nitric oxide are both involved in signaling, a direct relation...
Source: Nitric Oxide - August 10, 2018 Category: Chemistry Source Type: research
Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans
Publication date: Available online 8 August 2018Source: Nitric OxideAuthor(s): Rastislav Rovný, Martin Marko, Stanislav Katina, Jana Murínová, Veronika Roháriková, Barbora Cimrová, Gabriela Repiská, Gabriel Minárik, Igor RiečanskýAbstractResearch increasingly suggests that nitric oxide (NO) plays a role in the pathogenesis of schizophrenia. One important line of evidence comes from genetic studies, which have repeatedly detected an association between the neuronal isoform of nitric oxide synthase (nNOS or NOS1) and schizophrenia. However, the pathogenetic pathways linking nNOS, NO, and the disorder remain poorly ...
Source: Nitric Oxide - August 8, 2018 Category: Chemistry Source Type: research
