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Neuropathology,Volume 38, Issue 1, Page 2-2, February 2018. (Source: Neuropathology)
Source: Neuropathology - February 8, 2018 Category: Neurology Source Type: research
Le hazard ou la n écessité? Comorbid pathologies of neurodegenerative diseases
(Source: Neuropathology)
Source: Neuropathology - February 8, 2018 Category: Neurology Authors: Toshiki Uchihara, Toru Iwaki Tags: Preface Source Type: research
Issue Information
(Source: Neuropathology)
Source: Neuropathology - February 8, 2018 Category: Neurology Tags: Issue Information Source Type: research
Cover Image
(Source: Neuropathology)
Source: Neuropathology - February 8, 2018 Category: Neurology Tags: Cover Image Source Type: research
Clinicopathological and genetic association between epithelioid glioblastoma and pleomorphic xanthoastrocytoma
Epithelioid glioblastoma (eGBM) is a rare variant of GBM which was adopted in the 2016 WHO classification. eGBM and pleomorphic xanthoastrocytoma (PXA) sometimes show overlapping features histologically and genetically, such as epithelioid pattern and a highly frequent V600E mutation in the gene for vRAF murine sarcoma viral oncogene homolog B1 (BRAF), respectively. Accurate diagnosis of these rare tumors is challenging according to the new criteria in the revised 2016 WHO classification. It is an urgent task to elucidate the biological properties of the tumors and to select appropriate treatment. Twenty consecutive cases ...
Source: Neuropathology - February 1, 2018 Category: Neurology Authors: Takuya Furuta, Hiroaki Miyoshi, Satoru Komaki, Fumiko Arakawa, Motohiro Morioka, Koichi Ohshima, Mitsutoshi Nakada, Yasuo Sugita Tags: Original Article Source Type: research
Embryonal tumor with multilayered rosettes: Diagnosis on intra ‐operative squash smear
We describe a rare example of infratentorial primitive neuroectodermal tumor categorized as embryonal tumor with multilayered rosettes diagnosed on intra‐operative squash smear and frozen section and discuss its key diagnostic features, pitfalls and differentials. Correct interpretation at the time of frozen section is crucial as it helps in deciding the further course of surgery. To the best of our knowledge, this is the first such report in the literature. (Source: Neuropathology)
Source: Neuropathology - February 1, 2018 Category: Neurology Authors: Kirti Gupta, Vikram Singh, Ashish Aggarwal, Pravin Salunke Tags: Case Report Source Type: research
An autopsy case of globular glial tauopathy presenting with clinical features of motor neuron disease with dementia and iron deposition in the motor cortex
We report a case of GGT with iron deposits in a 78‐year‐old woman presenting with an 8‐year history of slowly progressing limb weakness and cognitive decline. Susceptibility‐weighted imaging revealed a low signal intensity in the right precentral gyrus, suggesting iron deposition. A clinical diagnosis of motor neuron disease with dementia was made 4 years after onset. At autopsy, gross pathological findings showed atrophy of the frontal and temporal lobes. A localized area of the precentral gyrus corresponding to the most severely affected limb showed the strongest atrophy, macroscopically, and displayed 4R tau...
Source: Neuropathology - February 1, 2018 Category: Neurology Authors: Itsuki Hasegawa, Akitoshi Takeda, Hiroyuki Hatsuta, Yuki Kubo, Masahiko Ohsawa, Yuta Nakano, Takeshi Ikeuchi, Masato Hasegawa, Shigeo Murayama, Yoshiaki Itoh Tags: Case Report Source Type: research
Gliosarcoma with primitive neuronal, chondroid, osteoid and ependymal elements
A 51‐year‐old man presented with a 2‐week history of malaise. MRI revealed a large solid and cystic lesion with ring enhancement measuring 6.5 cm in diameter in the right frontal lobe. Histologically, the tumor consisted of various components: diffuse growth of atypical astrocytic cells consistent with glioblastoma, fascicular proliferation of atypical spindle cells such as fibrosarcoma, clusters of primitive neuronal cells, and foci of ependymal cells. The sarcomatous component also focally exhibited chondroid and osteoid differentiation. Immunohistochemically, tumor cells in the primitive neuronal component were ...
Source: Neuropathology - February 1, 2018 Category: Neurology Authors: Yuka Yoshida, Munenori Ide, Hiroya Fujimaki, Nozomi Matsumura, Sumihito Nobusawa, Hayato Ikota, Hideaki Yokoo Tags: Case Report Source Type: research
Novel TLE4 ‐NTRK2 fusion in a ganglioglioma identified by array‐CGH and confirmed by NGS: Potential for a gene targeted therapy
Gangliogliomas are rare neoplasms of the central nervous system that mostly originate in the temporal lobe and are associated with seizures. Literature mentions that BRAF mutations are most commonly associated with gangliogliomas. We discuss a unique case of ganglioglioma originating in the posterior fossa that showed multiple losses and a unique interstitial deletion at 9q21 by an array‐comparative genome hybridization (array‐CGH). The deletion led to a novel molecular fusion (TLE4‐NTRK2) which was confirmed by next generation sequencing and provides a potential for a gene‐targeted therapy. (Source: Neuropathology)
Source: Neuropathology - February 1, 2018 Category: Neurology Authors: Nitya Prabhakaran, Miguel A. Guzman, Pournima Navalkele, Edna Chow ‐Maneval, Jacqueline R. Batanian Tags: Case Report Source Type: research
Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration
We present a case of hepatolenticular degeneration, so‐called Wilson’s disease (WD), in a 31‐year‐old Japanese man with broader deposition of copper in the liver, kidney and brain. The liver showed severe cirrhotic changes with macronodular pseudolobule formation, but there was little difference in immunohistochemical expression patterns of the copper transporter ATP7B between the control and present case. In the brain, there were both WD‐related lesions such as the scattering of Opalski cells and changes caused by hepatic encephalopathy including the appearance of Alzheimer type II glia. Of note, we identified c...
Source: Neuropathology - February 1, 2018 Category: Neurology Authors: Mayu Nishimuta, Kenta Masui, Tomoko Yamamoto, Yuichi Ikarashi, Katsutoshi Tokushige, Etsuko Hashimoto, Yoji Nagashima, Noriyuki Shibata Tags: Case Report Source Type: research
Low ‐grade fibromyxoid sarcoma arising within the median nerve
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - January 3, 2018 Category: Neurology Source Type: research
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Neuropathology, Ahead of Print. (Source: Neuropathology)
Source: Neuropathology - January 3, 2018 Category: Neurology Source Type: research
Adult moyamoya disease associated with abundant phosphorylated tau accumulation in the brainstem: Report of a case with autopsy findings
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - December 27, 2017 Category: Neurology Source Type: research
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Neuropathology, Ahead of Print. (Source: Neuropathology)
Source: Neuropathology - December 27, 2017 Category: Neurology Source Type: research
Atypical teratoid/rhabdoid tumor with retained INI1 (SMARCB1) expression and loss of BRG1 (SMARCA4)
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - December 21, 2017 Category: Neurology Source Type: research
