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No abstract is available for this article. (Source: Neuropathology)
Source: Neuropathology - January 31, 2017 Category: Neurology Tags: Issue Information Source Type: research
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(Source: Neuropathology)
Source: Neuropathology - January 31, 2017 Category: Neurology Tags: Cover Image Source Type: research
Schwannoma ‐like tumor in the anterior cranial fossa immunonegative for Leu7 but immunopositive for Schwann/2E
In conclusion, the origins of OGS and OECT remain to be determined, and further studies in larger numbers of cases are needed to characterize these rare tumors in the anterior cranial fossa. (Source: Neuropathology)
Source: Neuropathology - December 6, 2016 Category: Neurology Authors: Christian A ïssè Bohoun, Yuzo Terakawa, Takeo Goto, Sayaka Tanaka, Yuko Kuwae, Masahiko Ohsawa, Hiroki Morisako, Kosuke Nakajo, Hidetoshi Sato, Kenji Ohata, Hideaki Yokoo Tags: Case Report Source Type: research
Atypical case of perimesencephalic subarachnoid hemorrhage
We report an interesting case of a 57‐year‐old healthy man who presented initially with PM‐SAH with worsening of subcortical lesions on follow‐up neuroimaging. Histopathological examination demonstrated cerebral amyloid angiopathy with perivascular inflammation. (Source: Neuropathology)
Source: Neuropathology - December 6, 2016 Category: Neurology Authors: Konark Malhotra, Shino D. Magaki, Maria Inmaculada Cobos Sillero, Harry V. Vinters, Reza Jahan, Robert D. Brown, David S. Liebeskind Tags: Case Report Source Type: research
Dentatorubral ‐pallidoluysian atrophy (DRPLA) with a small ganglioglioma component containing neurofibrillary tangles and polyglutamine aggregation
Dentatorubral‐pallidoluysian atrophy (DRPLA), one of the polyglutamine diseases, has not been reported in combination with ganglioglioma (GG). Herein, we report an autopsy case of a 72‐year‐old man with DRPLA with a small GG component harboring neurofibrillary tangles (NFTs) and polyglutamine aggregates. NFTs, cytoplasmic accumulations of hyper‐phosphorylated tau, are mainly observed in Alzheimer's disease (AD) and other tau‐associated neurodegenerative disorders. NFTs can also be present in normal aging, and are occasionally observed in low‐grade central nervous system (CNS) neoplasms such as GG. In the presen...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Seiji Yamada, Tatsuya Yamazaki, Satoshi Nakata, Sumihito Nobusawa, Hayato Ikota, Munenori Ide, Kazuyuki Mizushima, Yasuo Harigaya, Junko Hirato, Hideaki Yokoo Tags: Case Report Source Type: research
Silencing of OTUB1 inhibits migration of human glioma cells in vitro
In this study, we sought to investigate the function of OTUB1 in the pathological process of gliomas and analyze its related clinical significance. Western blot and immunohistochemistry analyses demonstrated that OTUB1 was overexpressed in glioma tissues, and statistical analysis suggested the expression level of OTUB1 was significantly correlated with the WHO grades of human gliomas (P < 0.05). Moreover, Kaplan–Meier curve also indicated that high expression of OTUB1 was correlated with a poor prognosis. In vitro, silencing OTUB1 retarded the migration ability of glioma cells. Knockdown of OTUB1 increases epithelia...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Li Xu, Jinquan Li, Zhen Bao, Peng Xu, Hao Chang, Jingjing Wu, Yuanqi Bei, Liuwan Xia, Peizhang Wu, Ke Yan, Bing Lu, Gang Cui Tags: Original Article Source Type: research
Up ‐regulation of plakophilin‐2 is correlated with the progression of glioma
In this study, we demonstrated that PKP2 protein expression level was increased in glioma tissues compared with normal brain tissues, and its level was significantly associated with the Ki‐67 expression and WHO grade by Western blot analysis and immunohistochemistry. Clinically, high PKP2 expression was tightly related to poor prognosis of glioma patients. Interestingly, we found that down‐regulated PKP2 expression was shown to inhibit the migration of cells in glioma. Moreover, cell counting kit (CCK)‐8 and colony formation analyses proved that reduced expression of PKP2 could weaken glioma cell proliferation. Taken...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Degeng Zhang, Yuxia Qian, Xiaoxing Liu, Hong Yu, Niangao Zhao, Zhengdong Wu Tags: Original Article Source Type: research
Insular primary glioblastomas with IDH mutations: Clinical and biological specificities
Isocitrate dehydrogenase (IDH) mutation is a good prognostic marker for glioblastoma (GBM). Although it is infrequent in primary tumors, it is found in most lower‐grade gliomas. Thus, it is unclear whether IDH mutation is a marker for a specific phenotype of apparently primary de novo GBMs (pGBMs), or a marker for secondary tumors (sGBMs). We addressed this issue by analyzing clinical, radiographic and molecular findings in our institutional case series. Our cases included 92 pGBMs, with five cases of IDH1 mutations at R132 and no IDH2 mutations. The median overall survival of these five patients was 29 months (range: 4...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Nobuhiro Hata ( 秦暢宏), Ryusuke Hatae, Koji Yoshimoto, Hideki Murata, Daisuke Kuga, Yojiro Akagi, Yuhei Sangatsuda, Satoshi O. Suzuki, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara Tags: Original Article Source Type: research
Typical and atypical appearance of early ‐onset Alzheimer's disease: A clinical, neuroimaging and neuropathological study
We reported MRI, single‐photon emission CT and neuropathological findings in six representative cases. We also described a “left temporal variant” of AD presenting with transcortical cortical sensory aphasia, which has not been reported previously and is another subtype of the posterior variant of AD. We found a significant correlation between regional cerebral blood flow and counts of NFTs in the cerebral cortices. An atypical presentation with focal neuropsychological symptoms roughly correlated with the density of NFTs in the cerebral cortex and more directly related to spongiform changes in the superficial layers...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Shinobu Kawakatsu ( 川勝 忍), Ryota Kobayashi, Hiroshi Hayashi Tags: Symposium: Fundamentals learned from diversity among typical and atypical appearances Source Type: research
Pituitary adenoma with adipose tissue: A new metaplastic variant
Pituitary adenomas are benign tumors representing approximately 15–20% of intracranial neoplasms. There have been few reports of metaplastic osseous transformation and about 60 cases of neuronal metaplasia in pituitary adenoma but adipose metaplasia has not been previously described in the English literature. Here we report a case of pituitary adenoma with metaplastic adipose tissue in a 58‐year‐old male patient. Histologically this case fulfilled the criteria of a non‐functioning pituitary adenoma, and moreover a central area of adipose tissue, made by mature adipocytes, and many tumor cells, containing fat drople...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Chiara Caporalini, Anna Maria Buccoliero, Luigi Pansini, Selene Moscardi, Luca Novelli, Gianna Baroni, Lorenzo Bordi, Franco Ammannati, Gian Luigi Taddei Tags: Case Report Source Type: research
Well ‐formed cerebellum and brainstem‐like structures in a mature ovarian teratoma: Neuropathological observations
In the surgical case of a mature cystic teratoma of the ovary that arose in a 16‐year‐old girl, a large amount of well‐differentiated and highly organized cerebellar tissue was found. Three layers of the cerebellar cortex were well formed, and synaptophysin‐positive “glomeruli” were found in the granule cell layer. Some Purkinje cells exhibited focal expansion and a dysmorphic appearance of the dendrites. Adjacent to the cerebellar tissue, a large space lined by the ependymal layer and a club‐shaped CNS tissue mass resembling the brainstem were found, and structures reminiscent of the midbrain tectum and pont...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Masayuki Shintaku ( 新宅雅幸), Toshiko Sakuma, Chiho Ohbayashi, Motoyoshi Maruo Tags: Case Report Source Type: research
Creutzfeldt ‐Jakob disease
In conclusion, clinical and neuroimaging findings and neuropathologic observations are well matched in both typical and atypical cases in CJD. The clinical diagnosis of CJD is relatively easy for typical CJD cases such as the MM1‐type. However, even in atypical cases it seems that clinical findings can be used for an accurate diagnosis. (Source: Neuropathology)
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Yasushi Iwasaki (岩崎 靖) Tags: Symposium: Fundamentals learned from diversity among typical and atypical appearances Source Type: research
Biopsy ‐proven case of Epstein–Barr virus (EBV)‐associated vasculitis of the central nervous system
A 75‐year‐old woman was admitted to our hospital with rapidly deteriorating consciousness disturbance. She had a 7‐year history of rheumatoid arthritis (RA), which had been treated with methotrexate (MTX) and prednisolone. Brain T2‐weighted MRI showed diffuse high‐intensity lesions in the cerebral subcortical and deep white matter, bilateral basal ganglia and thalamus. A cerebrospinal fluid examination revealed elevated protein levels and positive Epstein–Barr virus (EBV) DNA. Human immunodeficiency virus was negative. Brain biopsy showed perivascular lymphocytic infiltration in the parenchyma and meninx with E...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Kohei Kano ( 鹿野耕平), Takayuki Katayama, Shiori Takeguchi, Asuka Asanome, Kae Takahashi, Tsukasa Saito, Jun Sawada, Masato Saito, Ryogo Anei, Kyousuke Kamada, Naoyuki Miyokawa, Hiroshi Nishihara, Naoyuki Hasebe Tags: Case Report Source Type: research
Dura mater graft ‐associated Creutzfeldt‐Jakob disease with 30‐year incubation period
Over 60% of all patients with dura mater graft‐associated Creutzfeldt‐Jakob disease (dCJD) have been diagnosed in Japan. The incubation period has ranged from 1 to 30 years and the age at onset from 15 to 80 years. Here, we report a 77‐year‐old male Japanese autopsied dCJD case with the longest incubation period so far in Japan. He received a cadaveric dural graft at the right cranial convexity following a craniotomy for meningioma at the age of 46. At 30 years post‐dural graft placement, disorientation was observed as an initial symptom of dCJD. He rapidly began to present with inconsistent speech, cognitive ...
Source: Neuropathology - November 30, 2016 Category: Neurology Authors: Masahiro Shijo, Hiroyuki Honda, Sachiko Koyama, Koji Ishitsuka, Koichiro Maeda, Junya Kuroda, Mitsugu Tanii, Takanari Kitazono, Toru Iwaki Tags: Case Report Source Type: research
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(Source: Neuropathology)
Source: Neuropathology - November 30, 2016 Category: Neurology Tags: Tribute to our Reviewers Source Type: research
