Clinicopathologic features and pathogenesis of melanocytic colonization in atypical meningioma
Neuropathology,Volume 38, Issue 1, Page 54-61, February 2018. (Source: Neuropathology)
Source: Neuropathology - August 18, 2017 Category: Neurology Source Type: research
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Neuropathology,Volume 38, Issue 1, Page 54-61, February 2018. (Source: Neuropathology)
Source: Neuropathology - August 18, 2017 Category: Neurology Source Type: research
Poorly differentiated chordoma with loss of SMARCB1/INI1 expression in pediatric patients: A report of two cases and review of the literature
Neuropathology,Volume 38, Issue 1, Page 47-53, February 2018. (Source: Neuropathology)
Source: Neuropathology - August 15, 2017 Category: Neurology Source Type: research
Gliosarcoma arising from oligodendroglioma, IDH mutant and 1p/19q codeleted
Neuropathology,Volume 38, Issue 1, Page 41-46, February 2018. (Source: Neuropathology)
Source: Neuropathology - August 15, 2017 Category: Neurology Source Type: research
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Neuropathology,Volume 38, Issue 1, Page 47-53, February 2018. (Source: Neuropathology)
Source: Neuropathology - August 15, 2017 Category: Neurology Source Type: research
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Neuropathology,Volume 38, Issue 1, Page 41-46, February 2018. (Source: Neuropathology)
Source: Neuropathology - August 15, 2017 Category: Neurology Source Type: research
Gliosarcoma arising from oligodendroglioma, IDH mutant and 1p/19q codeleted
Herein, we present a rare case of gliosarcoma arising from oligodendroglioma, isocitrate dehydrogenase (IDH) mutant and 1p/19q codeleted. A 36‐year‐old man presented with a non‐enhanced calcified abnormal lesion on the right frontal lobe. The patient underwent subtotal surgical resection, PAV chemotherapy (procarbazine, nimustine (ACNU) and vincristine), and fractionated radiotherapy with 50 Gy. The pathological diagnosis was oligodendroglioma, IDH mutant and 1p/19q codeleted, World Health Organization 2016 grade II. Six years later, a new enhanced lesion appeared, and the recurrent tumor was surgically removed. Al...
Source: Neuropathology - August 15, 2017 Category: Neurology Authors: Takayuki Yasuda, Masayuki Nitta, Takashi Komori, Tatsuya Kobayashi, Kenta Masui, Takashi Maruyama, Tatsuo Sawada, Yoshihiro Muragaki, Takakazu Kawamata Tags: Case Report Source Type: research
Issue Information
(Source: Neuropathology)
Source: Neuropathology - August 7, 2017 Category: Neurology Tags: Issue Information Source Type: research
Cover Image
(Source: Neuropathology)
Source: Neuropathology - August 7, 2017 Category: Neurology Tags: Cover Image Source Type: research
Evidence that glial cells attenuate G47R transthyretin accumulation in the central nervous system
This study aimed to clarify the reason why amyloid transthyretin (ATTR) rarely accumulates in the CNS. We pathologically analyzed the relationship between amyloid deposition with basement membranes or glial cells in a rare case of ATTR leptomeningeal amyloidosis. In addition, we compared the cytotoxicity of ATTR G47R, the amyloidosis‐causing mutation in the case studied (n = 1), and Aβ in brains from patients with cerebral amyloid angiopathy (n = 6). In the subarachnoid space of the ATTR G47R case, most amyloids accumulated at the components of basement membranes. On the CNS surface, ATTR accumulations were reta...
Source: Neuropathology - August 1, 2017 Category: Neurology Authors: Hisae Sumi ‐Akamaru, Masaki Eto, Amane Yamauchi, Takuya Uehara, Keita Kakuda, Konen Obayashi, Shinsuke Kato, Takashi Naka, Hideki Mochizuki Tags: Original Article Source Type: research
Possible concurrence of TDP ‐43, tau and other proteins in amyotrophic lateral sclerosis/frontotemporal lobar degeneration
Transactivation response DNA‐binding protein 43 kDa (TDP‐43) has been regarded as a major component of ubiquitin‐positive/tau‐negative inclusions of motor neurons and the frontotemporal cortices in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Neurofibrillary tangles (NFT), an example of tau‐positive inclusions, are biochemically and morphologically distinguished from TDP‐43‐positive inclusions, and are one of the pathological core features of Alzheimer disease (AD). Although ALS/FTLD and AD are distinct clinical entities, they can coexist in an individual patient. Whethe...
Source: Neuropathology - August 1, 2017 Category: Neurology Authors: Takahiro Takeda Tags: Symposium: Comorbid pathologies of neurodegenerative diseases Source Type: research
Molecular mechanisms of the co ‐deposition of multiple pathological proteins in neurodegenerative diseases
Intracellular inclusions composed of abnormal protein aggregates are one of the neuropathological features of neurodegenerative diseases, and the formation of intracellular aggregates is believed to be associated with neurodegeneration leading to the onset of these diseases. In typical or pure cases, characteristic pathologies with one particular protein, such as tau, alpha‐synuclein or trans‐activation response DNA protein 43 (TDP‐43), can be observed in brains of patients. On the other hand, multiple protein pathologies co‐exist in many cases, raising the possibility that they may influence each other reciprocall...
Source: Neuropathology - August 1, 2017 Category: Neurology Authors: Takashi Nonaka, Masami Masuda ‐Suzukake, Masato Hasegawa Tags: Symposium: Comorbid pathologies of neurodegenerative diseases Source Type: research
Pathological and immunoblot analysis of phosphorylated TDP ‐43 in sporadic amyotrophic lateral sclerosis with pallido‐nigro‐luysian degeneration
We describe here a 68‐year‐old ALS patient presenting severe PNLD. He had difficulty walking due to poor movement of his right leg, and was diagnosed as having Parkinson’s disease because of akinesia. About 2 years after onset, weakness of his left hand and leg led to a diagnosis of ALS. Tube feeding and non‐invasive positive‐pressure ventilation were initiated. He died of respiratory failure at the age of 71. There was no family history of either neurological disorders or dementia. Neuropathological examination revealed severe loss of neurons and gliosis in the PNL system in addition to the upper and lower mot...
Source: Neuropathology - August 1, 2017 Category: Neurology Authors: Akiko Uchino, Mieko Ogino, Junko Takahashi ‐Fujigasaki, Saori Oonuma, Naomi Kanazawa, Sabine Kajita, Masaaki Ichinoe, Masato Hasegawa, Kazutoshi Nishiyama, Shigeo Murayama Tags: Case Report Source Type: research
Clinicopathological and molecular characteristics of pediatric meningiomas
Molecular and clinical characteristics of pediatric meningiomas are poorly defined. Therefore, we analyzed clinical, morphological and molecular profiles of pediatric meningiomas. Forty pediatric meningiomas from January 2002 to June 2015 were studied. 1p36, 14q32 and 22q‐deletion were assessed by fluorescent in situ hybridization and mutations of most relevant exons of AKT, SMO, KLF4, TRAF and pTERT using sequencing. Expression of GAB1, stathmin, progesterone receptor (PR), p53 along with MIB‐1 LI was examined using immunohistochemistry. There were 36 sporadic and four NF2 associated meningiomas. Among sporadic mening...
Source: Neuropathology - August 1, 2017 Category: Neurology Authors: Sudha Battu, Anupam Kumar, Pankaj Pathak, Suvendu Purkait, Linchi Dhawan, Mehar C. Sharma, Ashish Suri, Manmohan Singh, Chitra Sarkar, Vaishali Suri Tags: Original Article Source Type: research
Diffuse midline gliomas with histone H3 ‐K27M mutation: A rare case with PNET‐like appearance and neuropil‐like islands
Diffuse midline glioma with histone H3‐K27M mutation is a new tumor entity defined by the 2016 WHO Classification of Tumors of the Central Nervous System. A 51‐year‐old Chinese woman presented with neck pain for a month. Subsequent MRI revealed an intramedullary neoplasm extending from C5 to C7. Histologically, the cellular area of the tumor was composed of primitive, poorly differentiated, small cells with scant cytoplasm, nuclear molding, and brisk mitotic activity, exhibiting PNET‐like appearance, while in the hypocellular area, oligodendroglioma‐like cells were observed. More importantly, neuropil‐like isla...
Source: Neuropathology - August 1, 2017 Category: Neurology Authors: Yue Gao, Yang ‐Yang Feng, Juan‐Han Yu, Qing‐Chang Li, Xue‐Shan Qiu, En‐Hua Wang Tags: Case Report Source Type: research
