Neuropathology and Applied Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

In This Issue
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 26, 2016 Category: Neurology Tags: In this Issue Source Type: research

Issue Information
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 26, 2016 Category: Neurology Tags: Issue Information Source Type: research

Brain iron accumulation in Wilson disease: a post mortem 7 Tesla MRI – histopathological study
ConclusionsT2/T2*w hypointensity observed in vivo in the basal ganglia of WD patients is related to iron rather than copper deposits. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - October 3, 2016 Category: Neurology Authors: P. Dusek, E. Bahn, T. Litwin, K. Jab łonka‐Salach, A. Łuciuk, T. Huelnhagen, V. I. Madai, M. A. Dieringer, E. Bulska, M. Knauth, T. Niendorf, J. Sobesky, F. Paul, S. A. Schneider, A. Czlonkowska, W. Brück, C. Wegner, J. Wuerfel Tags: Original Article Source Type: research

Deregulated expression of EZH2 in congenital brainstem disconnection
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 30, 2016 Category: Neurology Authors: P.G. Barth, E. Aronica, S. Fox, K. Fluiter, M.A.J. Weterman, A. Poretti, D.C. Miller, E. Boltshauser, B. Harding, M. Santi, F. Baas Tags: Scientific Correspondence Source Type: research

Clinicopathologic heterogeneity in FTDP ‐17 due to MAPT p.P301L mutation, including a patient with globular glial tauopathy
Conclusions: This clinicopathologic study shows inter‐ and intra‐familial clinicopathologic heterogeneity of FTDP‐17 due to MAPT p.P301L mutation, including GGT in one patient.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 30, 2016 Category: Neurology Authors: Pawel Tacik, Monica Sanchez ‐Contreras, Michael DeTure, Melissa E. Murray, Rosa Rademakers, Owen A. Ross, Zbigniew K. Wszolek, Joseph E. Parisi, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson Tags: Original Article Source Type: research

Association of cortical microinfarcts and cerebral small vessel pathology in the ageing brain
ConclusionsThe etiology of CMI differs depending on brain location. CAA may play a role principally in the occipital cortex. The large number of intact vessels around the CMI (mainly in the frontal cortex and hippocampus) raises the possibility that pathologies other than structural microangiopathy, including hypoperfusion/arterial hypotension or large vessel atherosclerosis, play a role in the development of microvascular lesions. These results are relevant in the context of etiopathogenesis of vascular changes associated with conditions like vascular dementia.This article is protected by copyright. All rights reserved. (...
Source: Neuropathology and Applied Neurobiology - September 30, 2016 Category: Neurology Authors: Enik ö Kövari, François R. Herrmann, Gabriel Gold, Patrick R. Hof, Andreas Charidimou Tags: Original Article Source Type: research

Meningeal SMARCB1 ‐deficient tumors: an emerging group of meningeal tumors
ConclusionsThe phenotype and genotype of these two cases did not fit diagnostically with entities already known to be SMARCB1‐deficient tumors. As both tumors shared common features, they are regarded as belonging to an emerging group of primary meningeal SMARCB1‐deficient tumors, not described to date. In order to facilitate the identification and characterization of these tumors, we recommend SMARCB1 immunohistochemistry for primary meningeal tumors which are difficult to classify, especially if immunopositive for EMA and CD34.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 30, 2016 Category: Neurology Authors: B érengère Dadone, Denys Fontaine, Lydiane Mondot, Gaël Cristofari, Anne Jouvet, Catherine Godfraind, Pascale Varlet, Dominique Ranchère‐Vince, Jean‐Michel Coindre, Lauris Gastaud, Christian Baudoin, Annie‐Claude Peyron, Antoine Thyss, Michael C Tags: Original Article Source Type: research

Review: Induced pluripotent stem cell models of frontotemporal dementia
The increasing prevalence of dementia in the ageing population combined with the lack of treatments and the burden on national health care systems globally make dementia a public health priority. Despite the plethora of important research findings published over the past two decades, the mechanisms underlying dementia are still poorly understood and the progress in pharmacological interventions is limited. Recent advances in cellular reprogramming and genome engineering technologies offer an unprecedented new paradigm in disease modeling. Induced pluripotent stem cells (iPSCs) have enabled the study of patient‐derived ne...
Source: Neuropathology and Applied Neurobiology - September 28, 2016 Category: Neurology Authors: E. Preza, J. Hardy, T. Warner, S. Wray Tags: Review Source Type: research

In this issue
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 28, 2016 Category: Neurology Tags: In This Issue Source Type: research

Issue Information
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 28, 2016 Category: Neurology Tags: Issue Information Source Type: research

Brain iron accumulation in Wilson disease: a post ‐mortem 7 Tesla MRI ‐ histopathological study
ConclusionsT2/T2*w hypointensity observed in vivo in the basal ganglia of WD patients is related to iron rather than copper deposits.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - August 19, 2016 Category: Neurology Authors: Petr Dusek, Erik Bahn, Tomasz Litwin, Katarzyna Jab łonka‐Salach, Anna Łuciuk, Till Huelnhagen, Vince Istvan Madai, Matthias A Dieringer, Ewa Bulska, Michael Knauth, Thoralf Niendorf, Jan Sobesky, Friedemann Paul, Susanne A Schneider, Anna Czlonkowska Tags: Original Article Source Type: research

Microinfarcts in an older population ‐representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease
ConclusionCortical (dementia) and subcortical microinfarcts (impaired mobility) are related to diverse clinical outcomes. Optimal pathological assessment of significant SVD in brain ageing is achieved based on white matter lesions, lacunes and microinfarcts and may not require subjective assessment of the extent and severity of arteriosclerosis.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 31, 2016 Category: Neurology Authors: Paul G Ince, Thais Minett, Gill Forster, Carol Brayne, Stephen B Wharton, Tags: Original Article Source Type: research

Progression of alpha ‐synuclein pathology in multiple system atrophy of the cerebellar type
ConclusionsOur findings indicate that cerebellar subcortical white matter and cerebellar brainstem projections are likely the earliest foci of α‐syn pathology in MSA‐C, followed by involvement of more widespread regions of the CNS and neurodegeneration with disease progression.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 31, 2016 Category: Neurology Authors: Johannes Brettschneider, David J. Irwin, Susana Boluda, Matthew D. Byrne, Lubin Fang, Edward B. Lee, John L. Robinson, EunRan Suh, Vivianna M. Van Deerlin, Jon B. Toledo, Murray Grossman, Howard Hurtig, Reinhard Dengler, Susanne Petri, Virginia M. ‐Y. L Tags: Original Article Source Type: research

Free ‐of‐acrylamide SDS‐based Tissue Clearing (FASTClear): A novel protocol of tissue clearing for three‐dimensional visualisation of human brain tissues
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 31, 2016 Category: Neurology Authors: Alan King Lun Liu, Hei Ming Lai, Raymond Chuen ‐Chung Chang, Steve M Gentleman Tags: Scientific Correspondence Source Type: research

Metastatic renal cell carcinoma metastasising into a cerebral cavernous malformation
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 31, 2016 Category: Neurology Authors: Jonathan Shapey, Rahul Phadke, Neil Kitchen Tags: Scientific Correspondence Source Type: research