Association of cortical microinfarcts and cerebral small vessel pathology in the ageing brain

ConclusionsThe etiology of CMI differs depending on brain location. CAA may play a role principally in the occipital cortex. The large number of intact vessels around the CMI (mainly in the frontal cortex and hippocampus) raises the possibility that pathologies other than structural microangiopathy, including hypoperfusion/arterial hypotension or large vessel atherosclerosis, play a role in the development of microvascular lesions. These results are relevant in the context of etiopathogenesis of vascular changes associated with conditions like vascular dementia.This article is protected by copyright. All rights reserved.

Source: Neuropathology and Applied Neurobiology - September 30, 2016 Category: Neurology Authors: Enik ö Kövari, François R. Herrmann, Gabriel Gold, Patrick R. Hof, Andreas Charidimou Tags: Original Article Source Type: research