Progression of alpha ‐synuclein pathology in multiple system atrophy of the cerebellar type

ConclusionsOur findings indicate that cerebellar subcortical white matter and cerebellar brainstem projections are likely the earliest foci of α‐syn pathology in MSA‐C, followed by involvement of more widespread regions of the CNS and neurodegeneration with disease progression.This article is protected by copyright. All rights reserved.

Source: Neuropathology and Applied Neurobiology - July 31, 2016 Category: Neurology Authors: Johannes Brettschneider, David J. Irwin, Susana Boluda, Matthew D. Byrne, Lubin Fang, Edward B. Lee, John L. Robinson, EunRan Suh, Vivianna M. Van Deerlin, Jon B. Toledo, Murray Grossman, Howard Hurtig, Reinhard Dengler, Susanne Petri, Virginia M. ‐Y. L Tags: Original Article Source Type: research