Neuropathology and Applied Neurobiology 
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(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 22, 2017 Category: Neurology Tags: Issue Information Source Type: research
In utero seizures revealing dentato ‐olivary dysplasia caused by SCN2A mutation
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 10, 2017 Category: Neurology Authors: Fanny Sauvestre, S ébastien Moutton, Catherine Badens, Bernard Broussin, Dominique Carles, Nada Houcinat, Caroline Lacoste, Florent Marguet, Christophe Pecheux, Laurent Villard, Fanny Pelluard, Annie Laquerrière, Gwenaëlle André Tags: Scientific Correspondence Source Type: research
Age ‐associated changes in the blood‐brain barrier: comparative studies in human and mouse
Neuropathology and Applied Neurobiology,Volume 44, Issue 3, Page 328-340, April 2018. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 28, 2017 Category: Neurology Source Type: research
The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome
Neuropathology and Applied Neurobiology,Volume 44, Issue 3, Page 314-327, April 2018. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 28, 2017 Category: Neurology Source Type: research
Heat shock protein expression in cerebral X ‐linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss
Neuropathology and Applied Neurobiology, EarlyView. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 26, 2017 Category: Neurology Source Type: research
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Neuropathology and Applied Neurobiology, Ahead of Print. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 26, 2017 Category: Neurology Source Type: research
Free of acrylamide sodium dodecyl sulphate (SDS) ‐based tissue clearing (FASTClear): a novel protocol of tissue clearing for three‐dimensional visualization of human brain tissues
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 19, 2017 Category: Neurology Authors: A. K. L. Liu, H. M. Lai, R. C. ‐C. Chang, S. M. Gentleman Tags: Scientific correspondence Source Type: research
Review: Tau in biofluids – relation to pathology, imaging and clinical features
Abstract
Tau is a microtubule‐binding protein that is important for the stability of neuronal axons. It is normally expressed within neurons and is also secreted into the brain interstitial fluid that communicates freely with cerebrospinal fluid (CSF) and, in a more restricted manner, blood via the glymphatic clearance system of the brain. In Alzheimer's disease (AD), neuroaxonal degeneration results in increased release of tau from neurons. Furthermore, tau is truncated and phosphorylated, which leads to aggregation of tau in neurofibrillary tangles of the proximal axoplasm. Neuroaxonal degeneration and tangle formation...
Source: Neuropathology and Applied Neurobiology - April 10, 2017 Category: Neurology Authors: H. Zetterberg Tags: Review Source Type: research
In This Issue
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 10, 2017 Category: Neurology Tags: In this Issue Source Type: research
Issue Information
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 10, 2017 Category: Neurology Tags: Issue Information Source Type: research
Bergmann glia translocation: a new disease marker for Vanishing White Matter identifies therapeutic effects of Guanabenz treatment
ConclusionsBergmann glia translocation can be used to objectively assess effects of treatment in VWM mice. Future treatment strategies involving compounds regulating eIF2 phosphorylation might benefit VWM patients.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 1, 2017 Category: Neurology Authors: Stephanie Dooves, Marianna Bugiani, Lisanne Wisse, Truus E.M. Abbink, Marjo S. van der Knaap, Vivi M. Heine Tags: Original Article Source Type: research
Diagnostic anoctamin ‐5 protein defect in patients with ANO5‐mutated muscular dystrophy
ConclusionsThe data presented here indicate that the ANO5 protein expression is decreased in ANO5‐mutated muscular dystrophy and that most of the non‐truncating pathogenic ANO5 mutations likely destabilize the protein and cause its degradation. The method described here allows direct analysis of human ANO5 protein, which can be used in diagnostics, for evaluating the pathogenicity of the potentially harmful ANO5 variants of uncertain significance.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 1, 2017 Category: Neurology Authors: A. Vihola, H. Luque, M. Savarese, S. Penttil ä, M. Lindfors, F. Leturcq, B. Eymard, G. Tasca, B. Brais, T. Conte, K. Charton, I. Richard, B. Udd Tags: Original Article Source Type: research
Age ‐associated changes in the blood brain barrier: Comparative studies in human and mouse
ConclusionsThis study demonstrates BBB dysfunction in normal brain ageing, both in human and mouse cohorts.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 1, 2017 Category: Neurology Authors: Emily F Goodall, Chunfang Wang, Julie E Simpson, David J Baker, David R Drew, Paul R Heath, M Jill Saffrey, Ignacio A Romero, Stephen B Wharton Tags: Original Article Source Type: research
The physiologic phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 1, 2017 Category: Neurology Authors: Ivan Milenkovic, Jasna Jarc, Eva Dassler, Eleonora Aronica, Anand Iyer, Homa Adle ‐Biassette, Anke Scharrer, Theresa Reischer, Johannes A. Hainfellner, Gabor G. Kovacs Tags: Original Article Source Type: research
Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex
ConclusionNeocortical neuronal loss in MS is massive and strongly predicted by cortical volume. Cortical volume decline detected in vivo may be similarly indicative of neuronal loss. Lack of association between neuronal density and demyelination suggests these features are partially independent, at least in chronic MS.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - April 1, 2017 Category: Neurology Authors: D Carassiti, D R Altmann, N Petrova, B Pakkenberg, F Scaravilli, K Schmierer Tags: Original Article Source Type: research
