Cancer stem cells revisited
Nature Medicine 23, 1124 (2017).
doi:10.1038/nm.4409
Authors: Eduard Batlle & Hans Clevers (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Eduard Batlle Hans Clevers Tags: Review Source Type: research
Noncoding RNAs as effective markers in cancer-care management
Nature Medicine 23, 1122 (2017).
doi:10.1038/nm.4423
Authors: Ivan Raimondi & Maite Huarte
Two recent studies show that 'silent' variants can modulate regulatory circuits, including those in noncoding RNAs, affecting cancer predisposition and drug sensitivity. (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Ivan Raimondi Maite Huarte Tags: News and Views Source Type: research
Engineering MeCP2 to spy on its targets
Nature Medicine 23, 1120 (2017).
doi:10.1038/nm.4425
Authors: Patricia M Horvath & Lisa M Monteggia
A new mouse model of Rett syndrome, in which MECP2 can be selectively biotinylated, allows for the investigation of cell-specific effects of Rett-causing mutations on gene expression, particularly in female mice. (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Patricia M Horvath Lisa M Monteggia Tags: News and Views Source Type: research
GDF15 and energy balance: homing in on a mechanism
Nature Medicine 23, 1119 (2017).
doi:10.1038/nm.4414
Authors: Irene Cimino, Anthony P Coll & Giles S H Yeo
Three recent studies in mice have identified a specific receptor, GFRAL, for the known anorectic peptide GDF15. The finding increases mechanistic understanding of its effect and paves the way for the development of novel anti-obesity therapeutics. (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Irene Cimino Anthony P Coll Giles S H Yeo Tags: News and Views Source Type: research
Mission control: Drug developers test the 'benefit corporation' business model
Nature Medicine 23, 1117 (2017).
doi:10.1038/nm1017-1117
Author: Arran Frood (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Arran Frood Tags: News Source Type: research
Angst about exclusivity: The potential cost of incentivizing makers of generic drugs
Nature Medicine 23, 1114 (2017).
doi:10.1038/nm1017-1114
Authors: Shraddha Chakradhar & Roxanne Khamsi (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Shraddha Chakradhar Roxanne Khamsi Tags: News Source Type: research
Rationalizing combination therapies
Nature Medicine 23, 1113 (2017).
doi:10.1038/nm.4426
A growing number of clinical trials on combination therapies raises the question of to what degree they may be redundant. Systems biology and hypothesis-driven preclinical studies could help to identify the most promising candidates for clinical trials, and also offer new insights into the biological mechanisms that underlie drug synergies. (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Tags: Editorial Source Type: research
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Nature Medicine 23, 1362 (2017).
doi:10.1038/nm.4407
Authors: Rodrigo Romero, Volkan I Sayin, Shawn M Davidson, Matthew R Bauer, Simranjit X Singh, Sarah E LeBoeuf, Triantafyllia R Karakousi, Donald C Ellis, Arjun Bhutkar, Francisco J Sánchez-Rivera, Lakshmipriya Subbaraj, Britney Martinez, Roderick T Bronson, Justin R Prigge, Edward E Schmidt, Craig J Thomas, Chandra Goparaju, Angela Davies, Igor Dolgalev, Adriana Heguy, Viola Allaj, John T Poirier, Andre L Moreira, Charles M Rudin, Harvey I Pass, Matthew G Vander Heiden, Tyler Jacks & Thales Papagiannakopoulos
Treating KRAS-mutant lung adenocarcinoma (LU...
Source: Nature Medicine - October 2, 2017 Category: General Medicine Authors: Rodrigo Romero Volkan I Sayin Shawn M Davidson Matthew R Bauer Simranjit X Singh Sarah E LeBoeuf Triantafyllia R Karakousi Donald C Ellis Arjun Bhutkar Francisco J S รก nchez-Rivera Lakshmipriya Subbaraj Britney Martinez Roderick T Bronson Justin R Prigge Tags: Letter Source Type: research
Defining total-body AIDS-virus burden with implications for curative strategies
Nature Medicine 23, 1271 (2017).
doi:10.1038/nm.4411
Authors: Jacob D Estes, Cissy Kityo, Francis Ssali, Louise Swainson, Krystelle Nganou Makamdop, Gregory Q Del Prete, Steven G Deeks, Paul A Luciw, Jeffrey G Chipman, Gregory J Beilman, Torfi Hoskuldsson, Alexander Khoruts, Jodi Anderson, Claire Deleage, Jacob Jasurda, Thomas E Schmidt, Michael Hafertepe, Samuel P Callisto, Hope Pearson, Thomas Reimann, Jared Schuster, Jordan Schoephoerster, Peter Southern, Katherine Perkey, Liang Shang, Stephen W Wietgrefe, Courtney V Fletcher, Jeffrey D Lifson, Daniel C Douek, Joseph M McCune, Ashley T Haase & Timothy W Scha...
Source: Nature Medicine - October 2, 2017 Category: General Medicine Authors: Jacob D Estes Cissy Kityo Francis Ssali Louise Swainson Krystelle Nganou Makamdop Gregory Q Del Prete Steven G Deeks Paul A Luciw Jeffrey G Chipman Gregory J Beilman Torfi Hoskuldsson Alexander Khoruts Jodi Anderson Claire Deleage Jacob Jasurda Thomas E S Tags: Article Source Type: research
Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence
Nature Medicine 23, 1319 (2017).
doi:10.1038/nm.4405
Authors: Jian Yuan Goh, Min Feng, Wenyu Wang, Gokce Oguz, Siti Maryam J M Yatim, Puay Leng Lee, Yi Bao, Tse Hui Lim, Panpan Wang, Wai Leong Tam, Annette R Kodahl, Maria B Lyng, Suman Sarma, Selena Y Lin, Alexander Lezhava, Yoon Sim Yap, Alvin S T Lim, Dave S B Hoon, Henrik J Ditzel, Soo Chin Lee, Ern Yu Tan & Qiang Yu (Source: Nature Medicine)
Source: Nature Medicine - September 25, 2017 Category: General Medicine Authors: Jian Yuan Goh Min Feng Wenyu Wang Gokce Oguz Siti Maryam J M Yatim Puay Leng Lee Yi Bao Tse Hui Lim Panpan Wang Wai Leong Tam Annette R Kodahl Maria B Lyng Suman Sarma Selena Y Lin Alexander Lezhava Yoon Sim Yap Alvin S T Lim Dave S B Hoon Henrik J Ditzel Tags: Article Source Type: research
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
Nature Medicine 23, 1369 (2017).
doi:10.1038/nm.4416
Authors: Ly P Vu, Brian F Pickering, Yuanming Cheng, Sara Zaccara, Diu Nguyen, Gerard Minuesa, Timothy Chou, Arthur Chow, Yogesh Saletore, Matthew MacKay, Jessica Schulman, Christopher Famulare, Minal Patel, Virginia M Klimek, Francine E Garrett-Bakelman, Ari Melnick, Martin Carroll, Christopher E Mason, Samie R Jaffrey & Michael G Kharas (Source: Nature Medicine)
Source: Nature Medicine - September 18, 2017 Category: General Medicine Authors: Ly P Vu Brian F Pickering Yuanming Cheng Sara Zaccara Diu Nguyen Gerard Minuesa Timothy Chou Arthur Chow Yogesh Saletore Matthew MacKay Jessica Schulman Christopher Famulare Minal Patel Virginia M Klimek Francine E Garrett-Bakelman Ari Melnick Martin Carr Tags: Letter Source Type: research
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Nature Medicine 23, 1234 (2017).
doi:10.1038/nm.4399
Authors: Elodie M Kuntz, Pablo Baquero, Alison M Michie, Karen Dunn, Saverio Tardito, Tessa L Holyoake, G Vignir Helgason & Eyal Gottlieb
Treatment of chronic myeloid leukemia (CML) with imatinib mesylate and other second- and/or third-generation c-Abl-specific tyrosine kinase inhibitors (TKIs) has substantially extended patient survival. However, TKIs primarily target differentiated cells and do not eliminate leukemic stem cells (LSCs). Therefore, targeting minimal residual disease to prevent acquired resistance and/or disease relapse requires identification...
Source: Nature Medicine - September 18, 2017 Category: General Medicine Authors: Elodie M Kuntz Pablo Baquero Alison M Michie Karen Dunn Saverio Tardito Tessa L Holyoake G Vignir Helgason Eyal Gottlieb Tags: Letter Source Type: research
Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome
Nature Medicine 23, 1203 (2017).
doi:10.1038/nm.4406
Authors: Brian S Johnson, Ying-Tao Zhao, Maria Fasolino, Janine M Lamonica, Yoon Jung Kim, George Georgakilas, Kathleen H Wood, Daniel Bu, Yue Cui, Darren Goffin, Golnaz Vahedi, Tae Hoon Kim & Zhaolan Zhou (Source: Nature Medicine)
Source: Nature Medicine - September 18, 2017 Category: General Medicine Authors: Brian S Johnson Ying-Tao Zhao Maria Fasolino Janine M Lamonica Yoon Jung Kim George Georgakilas Kathleen H Wood Daniel Bu Yue Cui Darren Goffin Golnaz Vahedi Tae Hoon Kim Zhaolan Zhou Tags: Article Source Type: research
KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis
Nature Medicine 23, 1176 (2017).
doi:10.1038/nm.4400
Authors: Meera Murgai, Wei Ju, Matthew Eason, Jessica Kline, Daniel W Beury, Sabina Kaczanowska, Markku M Miettinen, Michael Kruhlak, Haiyan Lei, Jack F Shern, Olga A Cherepanova, Gary K Owens & Rosandra N Kaplan (Source: Nature Medicine)
Source: Nature Medicine - September 18, 2017 Category: General Medicine Authors: Meera Murgai Wei Ju Matthew Eason Jessica Kline Daniel W Beury Sabina Kaczanowska Markku M Miettinen Michael Kruhlak Haiyan Lei Jack F Shern Olga A Cherepanova Gary K Owens Rosandra N Kaplan Tags: Article Source Type: research
Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma
Nature Medicine 23, 1167 (2017).
doi:10.1038/nm.4401
Authors: Daniel S W Tan, Fui Teen Chong, Hui Sun Leong, Shen Yon Toh, Dawn P Lau, Xue Lin Kwang, Xiaoqian Zhang, Gopinath M Sundaram, Gek San Tan, Mei Mei Chang, Boon Tin Chua, Wan Teck Lim, Eng Huat Tan, Mei Kim Ang, Tony K H Lim, Prabha Sampath, Balram Chowbay, Anders J Skanderup, Ramanuj DasGupta & N Gopalakrishna Iyer (Source: Nature Medicine)
Source: Nature Medicine - September 18, 2017 Category: General Medicine Authors: Daniel S W Tan Fui Teen Chong Hui Sun Leong Shen Yon Toh Dawn P Lau Xue Lin Kwang Xiaoqian Zhang Gopinath M Sundaram Gek San Tan Mei Mei Chang Boon Tin Chua Wan Teck Lim Eng Huat Tan Mei Kim Ang Tony K H Lim Prabha Sampath Balram Chowbay Anders J Skanderu Tags: Article Source Type: research
