Correction
Nature Medicine 23, 1391 (2017).
doi:10.1038/nm1217-1391 (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Tags: Correction Source Type: research
Timeline of events
Nature Medicine 23, 1390 (2017).
doi:10.1038/nm1217-1390
Author: Shraddha Chakradhar
From a worldwide march in favor of science to an increased focus on diversity and gender equality in the workplace, 2017 was a year that was dominated by activism and social causes. Amidst these events, however, were concerns over unproven treatments and emergency funding. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
Notable advances 2017
Nature Medicine 23, 1387 (2017).
doi:10.1038/nm1217-1387
Authors: Tanya Bondar, Javier Carmona, Kate Gao, Brett Benedetti, Michael Basson, Randy Levinson, Hannah Stower & Alison Farrell
This past year included numerous research studies that broke the mold and elucidated new biology and drug targets. Here are some of the exciting papers from 2017 that moved biomedicine forward. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Tanya Bondar Javier Carmona Kate Gao Brett Benedetti Michael Basson Randy Levinson Hannah Stower Alison Farrell Tags: News Source Type: research
The Yearbook
Nature Medicine 23, 1386 (2017).
doi:10.1038/nm1217-1386
Author: Shraddha Chakradhar
From policy advisors who resigned in protest to an agency trying to settle a patent dispute, many of the newsmakers in our 2017 Yearbook made notable decisions. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
Cutting out the liver fat
Nature Medicine 23, 1385 (2017).
doi:10.1038/nm.4459
Better animal models of nonalcoholic steatohepatitis are needed to more fully understand the disease and to identify potential new therapeutic treatments for this increasingly common condition. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Tags: Editorial Source Type: research
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
Nature Medicine 24, 39 (2018).
doi:10.1038/nm.4447
Authors: Guoying Yu, Argyris Tzouvelekis, Rong Wang, Jose D Herazo-Maya, Gabriel H Ibarra, Anup Srivastava, Joao Pedro Werneck de Castro, Giuseppe DeIuliis, Farida Ahangari, Tony Woolard, Nachelle Aurelien, Rafael Arrojo e Drigo, Ye Gan, Morven Graham, Xinran Liu, Robert J Homer, Thomas S Scanlan, Praveen Mannam, Patty J Lee, Erica L Herzog, Antonio C Bianco & Naftali Kaminski (Source: Nature Medicine)
Source: Nature Medicine - December 4, 2017 Category: General Medicine Authors: Guoying Yu Argyris Tzouvelekis Rong Wang Jose D Herazo-Maya Gabriel H Ibarra Anup Srivastava Joao Pedro Werneck de Castro Giuseppe DeIuliis Farida Ahangari Tony Woolard Nachelle Aurelien Rafael Arrojo e Drigo Ye Gan Morven Graham Xinran Liu Robert J Homer Tags: Article Source Type: research
Amyloid- β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Nature Medicine 24, 29 (2018).
doi:10.1038/nm.4443
Authors: Zhuohao He, Jing L Guo, Jennifer D McBride, Sneha Narasimhan, Hyesung Kim, Lakshmi Changolkar, Bin Zhang, Ronald J Gathagan, Cuiyong Yue, Christopher Dengler, Anna Stieber, Magdalena Nitla, Douglas A Coulter, Ted Abel, Kurt R Brunden, John Q Trojanowski & Virginia M-Y Lee (Source: Nature Medicine)
Source: Nature Medicine - December 4, 2017 Category: General Medicine Authors: Zhuohao He Jing L Guo Jennifer D McBride Sneha Narasimhan Hyesung Kim Lakshmi Changolkar Bin Zhang Ronald J Gathagan Cuiyong Yue Christopher Dengler Anna Stieber Magdalena Nitla Douglas A Coulter Ted Abel Kurt R Brunden John Q Trojanowski Virginia M-Y Lee Tags: Article Source Type: research
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Nature Medicine 24, 50 (2018).
doi:10.1038/nm.4450
Authors: Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim, Dongxu Fu, Ivana Apicella, Akhil Varshney, Reo Yasuma, Benjamin J Fowler, Elmira Baghdasaryan, Kenneth M Marion, Xiwen Huang, Tetsuhiro Yasuma, Yoshio Hirano, Vlad Serbulea, Meenakshi Ambati, Vidya L Ambati, Yuji Kajiwara, Kameshwari Ambati, Shuichiro Hirahara, Ana Bastos-Carvalho, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Kyung Bo Kim, David R Hinton, Norbert Leitinger, John C Cambier, Joseph D Buxbaum, M Cristina Kenney, S Michal Jazwinski, Hiroshi Nagai, Isao Hara, A Phillip West, K...
Source: Nature Medicine - November 27, 2017 Category: General Medicine Authors: Nagaraj Kerur Shinichi Fukuda Daipayan Banerjee Younghee Kim Dongxu Fu Ivana Apicella Akhil Varshney Reo Yasuma Benjamin J Fowler Elmira Baghdasaryan Kenneth M Marion Xiwen Huang Tetsuhiro Yasuma Yoshio Hirano Vlad Serbulea Meenakshi Ambati Vidya L Ambati Tags: Article Source Type: research
Granulocyte-derived TNF α promotes vascular and hematopoietic regeneration in the bone marrow
Nature Medicine 24, 95 (2018).
doi:10.1038/nm.4448
Authors: Emily Bowers, Anastasiya Slaughter, Paul S Frenette, Rork Kuick, Oscar M Pello & Daniel Lucas
Endothelial cells are a critical component of the bone marrow (BM) stromal network, which maintains and regulates hematopoietic cells. Vascular regeneration precedes, and is necessary for, successful hematopoietic stem cell (HSC) transplantation, the only cure for most hematopoietic diseases. Recent data suggest that mature hematopoietic cells regulate BM stromal-cell function. Whether a similar cross-talk regulates the BM vasculature is not known. Here we fou...
Source: Nature Medicine - November 20, 2017 Category: General Medicine Authors: Emily Bowers Anastasiya Slaughter Paul S Frenette Rork Kuick Oscar M Pello Daniel Lucas Tags: Letter Source Type: research
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
Nature Medicine 24, 20 (2018).
doi:10.1038/nm.4441
Authors: Terry J Fry, Nirali N Shah, Rimas J Orentas, Maryalice Stetler-Stevenson, Constance M Yuan, Sneha Ramakrishna, Pamela Wolters, Staci Martin, Cindy Delbrook, Bonnie Yates, Haneen Shalabi, Thomas J Fountaine, Jack F Shern, Robbie G Majzner, David F Stroncek, Marianna Sabatino, Yang Feng, Dimiter S Dimitrov, Ling Zhang, Sang Nguyen, Haiying Qin, Boro Dropulic, Daniel W Lee & Crystal L Mackall (Source: Nature Medicine)
Source: Nature Medicine - November 20, 2017 Category: General Medicine Authors: Terry J Fry Nirali N Shah Rimas J Orentas Maryalice Stetler-Stevenson Constance M Yuan Sneha Ramakrishna Pamela Wolters Staci Martin Cindy Delbrook Bonnie Yates Haneen Shalabi Thomas J Fountaine Jack F Shern Robbie G Majzner David F Stroncek Marianna Saba Tags: Article Source Type: research
Enhancing the precision of genetic lineage tracing using dual recombinases
Nature Medicine 23, 1488 (2017).
doi:10.1038/nm.4437
Authors: Lingjuan He, Yan Li, Yi Li, Wenjuan Pu, Xiuzhen Huang, Xueying Tian, Yue Wang, Hui Zhang, Qiaozhen Liu, Libo Zhang, Huan Zhao, Juan Tang, Hongbin Ji, Dongqing Cai, Zhibo Han, Zhongchao Han, Yu Nie, Shengshou Hu, Qing-Dong Wang, Ruilin Sun, Jian Fei, Fengchao Wang, Ting Chen, Yan Yan, Hefeng Huang, William T Pu & Bin Zhou (Source: Nature Medicine)
Source: Nature Medicine - November 13, 2017 Category: General Medicine Authors: Lingjuan He Yan Li Yi Li Wenjuan Pu Xiuzhen Huang Xueying Tian Yue Wang Hui Zhang Qiaozhen Liu Libo Zhang Huan Zhao Juan Tang Hongbin Ji Dongqing Cai Zhibo Han Zhongchao Han Yu Nie Shengshou Hu Qing-Dong Wang Ruilin Sun Jian Fei Fengchao Wang Ting Chen Ya Tags: Technical Report Source Type: research
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
Nature Medicine 23, 1454 (2017).
doi:10.1038/nm.4429
Authors: Kenji Ikeda, Qianqian Kang, Takeshi Yoneshiro, Joao Paulo Camporez, Hiroko Maki, Mayu Homma, Kosaku Shinoda, Yong Chen, Xiaodan Lu, Pema Maretich, Kazuki Tajima, Kolapo M Ajuwon, Tomoyoshi Soga & Shingo Kajimura (Source: Nature Medicine)
Source: Nature Medicine - November 13, 2017 Category: General Medicine Authors: Kenji Ikeda Qianqian Kang Takeshi Yoneshiro Joao Paulo Camporez Hiroko Maki Mayu Homma Kosaku Shinoda Yong Chen Xiaodan Lu Pema Maretich Kazuki Tajima Kolapo M Ajuwon Tomoyoshi Soga Shingo Kajimura Tags: Article Source Type: research
Human primary liver cancer – derived organoid cultures for disease modeling and drug screening
Nature Medicine 23, 1424 (2017).
doi:10.1038/nm.4438
Authors: Laura Broutier, Gianmarco Mastrogiovanni, Monique MA Verstegen, Hayley E Francies, Lena Morrill Gavarró, Charles R Bradshaw, George E Allen, Robert Arnes-Benito, Olga Sidorova, Marcia P Gaspersz, Nikitas Georgakopoulos, Bon-Kyoung Koo, Sabine Dietmann, Susan E Davies, Raaj K Praseedom, Ruby Lieshout, Jan N M IJzermans, Stephen J Wigmore, Kourosh Saeb-Parsy, Mathew J Garnett, Luc JW van der Laan & Meritxell Huch (Source: Nature Medicine)
Source: Nature Medicine - November 13, 2017 Category: General Medicine Authors: Laura Broutier Gianmarco Mastrogiovanni Monique MA Verstegen Hayley E Francies Lena Morrill Gavarr ó Charles R Bradshaw George E Allen Robert Arnes-Benito Olga Sidorova Marcia P Gaspersz Nikitas Georgakopoulos Bon-Kyoung Koo Sabine Dietmann Susan E Davie Tags: Article Source Type: research
Targeting the T cell receptor β -chain constant region for immunotherapy of T cell malignancies
Nature Medicine 23, 1416 (2017).
doi:10.1038/nm.4444
Authors: Paul M Maciocia, Patrycja A Wawrzyniecka, Brian Philip, Ida Ricciardelli, Ayse U Akarca, Shimobi C Onuoha, Mateusz Legut, David K Cole, Andrew K Sewell, Giuseppe Gritti, Joan Somja, Miguel A Piris, Karl S Peggs, David C Linch, Teresa Marafioti & Martin A Pule (Source: Nature Medicine)
Source: Nature Medicine - November 13, 2017 Category: General Medicine Authors: Paul M Maciocia Patrycja A Wawrzyniecka Brian Philip Ida Ricciardelli Ayse U Akarca Shimobi C Onuoha Mateusz Legut David K Cole Andrew K Sewell Giuseppe Gritti Joan Somja Miguel A Piris Karl S Peggs David C Linch Teresa Marafioti Martin A Pule Tags: Article Source Type: research
Corrigendum: Genome-wide CRISPR screens reveal a Wnt – FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Nature Medicine 23, 1384 (2017).
doi:10.1038/nm1117-1384d
Authors: Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar, Traver Hart, Xiaowei Wang, Xiaoyu Zhang, Mélanie Robitaille, Kevin R Brown, Sridevi Jaksani, René Overmeer, Sylvia F Boj, Jarrett Adams, James Pan, Hans Clevers, Sachdev Sidhu, Jason Moffat & Stéphane Angers (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Zachary Steinhart Zvezdan Pavlovic Megha Chandrashekhar Traver Hart Xiaowei Wang Xiaoyu Zhang M é lanie Robitaille Kevin R Brown Sridevi Jaksani Ren é Overmeer Sylvia F Boj Jarrett Adams James Pan Hans Clevers Sachdev Sidhu Jason Moffat St é phane Ang Tags: Corrigendum Source Type: research
