GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
Nature Medicine 23, 1150 (2017).
doi:10.1038/nm.4392
Authors: Shannon E Mullican, Xiefan Lin-Schmidt, Chen-Ni Chin, Jose A Chavez, Jennifer L Furman, Anthony A Armstrong, Stephen C Beck, Victoria J South, Thai Q Dinh, Tanesha D Cash-Mason, Cassandre R Cavanaugh, Serena Nelson, Chichi Huang, Michael J Hunter & Shamina M Rangwala (Source: Nature Medicine)
Source: Nature Medicine - August 28, 2017 Category: General Medicine Authors: Shannon E Mullican Xiefan Lin-Schmidt Chen-Ni Chin Jose A Chavez Jennifer L Furman Anthony A Armstrong Stephen C Beck Victoria J South Thai Q Dinh Tanesha D Cash-Mason Cassandre R Cavanaugh Serena Nelson Chichi Huang Michael J Hunter Shamina M Rangwala Tags: Article Source Type: research
Sex-specific transcriptional signatures in human depression
Nature Medicine 23, 1102 (2017).
doi:10.1038/nm.4386
Authors: Benoit Labonté, Olivia Engmann, Immanuel Purushothaman, Caroline Menard, Junshi Wang, Chunfeng Tan, Joseph R Scarpa, Gregory Moy, Yong-Hwee E Loh, Michael Cahill, Zachary S Lorsch, Peter J Hamilton, Erin S Calipari, Georgia E Hodes, Orna Issler, Hope Kronman, Madeline Pfau, Aleksandar L J Obradovic, Yan Dong, Rachael L Neve, Scott Russo, Andrew Kazarskis, Carol Tamminga, Naguib Mechawar, Gustavo Turecki, Bin Zhang, Li Shen & Eric J Nestler (Source: Nature Medicine)
Source: Nature Medicine - August 21, 2017 Category: General Medicine Authors: Benoit Labont é Olivia Engmann Immanuel Purushothaman Caroline Menard Junshi Wang Chunfeng Tan Joseph R Scarpa Gregory Moy Yong-Hwee E Loh Michael Cahill Zachary S Lorsch Peter J Hamilton Erin S Calipari Georgia E Hodes Orna Issler Hope Kronman Madeline Tags: Resource Source Type: research
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels
Nature Medicine 23, 1086 (2017).
doi:10.1038/nm.4390
Authors: Sumeet A Khetarpal, Xuemei Zeng, John S Millar, Cecilia Vitali, Amritha Varshini Hanasoge Somasundara, Paolo Zanoni, James A Landro, Nicole Barucci, William J Zavadoski, Zhiyuan Sun, Hans de Haard, Ildikó V Toth, Gina M Peloso, Pradeep Natarajan, Marina Cuchel, Sissel Lund-Katz, Michael C Phillips, Alan R Tall, Sekar Kathiresan, Paul DaSilva-Jardine, Nathan A Yates & Daniel J Rader
Recent large-scale genetic sequencing efforts have identified rare coding variants in genes in the triglyceride-rich lipoprotein (TRL) clearance pathway that are prot...
Source: Nature Medicine - August 21, 2017 Category: General Medicine Authors: Sumeet A Khetarpal Xuemei Zeng John S Millar Cecilia Vitali Amritha Varshini Hanasoge Somasundara Paolo Zanoni James A Landro Nicole Barucci William J Zavadoski Zhiyuan Sun Hans de Haard Ildik ó V Toth Gina M Peloso Pradeep Natarajan Marina Cuchel Sisse Tags: Letter Source Type: research
Targeting cellular senescence prevents age-related bone loss in mice
Nature Medicine 23, 1072 (2017).
doi:10.1038/nm.4385
Authors: Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G Fraser, Jennifer L Onken, Brittany A Negley, Jad G Sfeir, Mikolaj B Ogrodnik, Christine M Hachfeld, Nathan K LeBrasseur, Matthew T Drake, Robert J Pignolo, Tamar Pirtskhalava, Tamara Tchkonia, Merry Jo Oursler, James L Kirkland & Sundeep Khosla
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent cells in age-related bone loss through multiple approaches. In pa...
Source: Nature Medicine - August 21, 2017 Category: General Medicine Authors: Joshua N Farr Ming Xu Megan M Weivoda David G Monroe Daniel G Fraser Jennifer L Onken Brittany A Negley Jad G Sfeir Mikolaj B Ogrodnik Christine M Hachfeld Nathan K LeBrasseur Matthew T Drake Robert J Pignolo Tamar Pirtskhalava Tamara Tchkonia Merry Jo Ou Tags: Letter Source Type: research
Prostate cancer – associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
Nature Medicine 23, 1063 (2017).
doi:10.1038/nm.4378
Authors: Xiangpeng Dai, Wenjian Gan, Xiaoning Li, Shangqian Wang, Wei Zhang, Ling Huang, Shengwu Liu, Qing Zhong, Jianping Guo, Jinfang Zhang, Ting Chen, Kouhei Shimizu, Francisco Beca, Mirjam Blattner, Divya Vasudevan, Dennis L Buckley, Jun Qi, Lorenz Buser, Pengda Liu, Hiroyuki Inuzuka, Andrew H Beck, Liewei Wang, Peter J Wild, Levi A Garraway, Mark A Rubin, Christopher E Barbieri, Kwok-Kin Wong, Senthil K Muthuswamy, Jiaoti Huang, Yu Chen, James E Bradner & Wenyi Wei
The bromodomain and extraterminal (BET) family of proteins comprises four members—BR...
Source: Nature Medicine - August 14, 2017 Category: General Medicine Authors: Xiangpeng Dai Wenjian Gan Xiaoning Li Shangqian Wang Wei Zhang Ling Huang Shengwu Liu Qing Zhong Jianping Guo Jinfang Zhang Ting Chen Kouhei Shimizu Francisco Beca Mirjam Blattner Divya Vasudevan Dennis L Buckley Jun Qi Lorenz Buser Pengda Liu Hiroyuki In Tags: Letter Source Type: research
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT – mTORC1 activation
Nature Medicine 23, 1055 (2017).
doi:10.1038/nm.4379
Authors: Pingzhao Zhang, Dejie Wang, Yu Zhao, Shancheng Ren, Kun Gao, Zhenqing Ye, Shangqian Wang, Chun-Wu Pan, Yasheng Zhu, Yuqian Yan, Yinhui Yang, Di Wu, Yundong He, Jun Zhang, Daru Lu, Xiuping Liu, Long Yu, Shimin Zhao, Yao Li, Dong Lin, Yuzhuo Wang, Liguo Wang, Yu Chen, Yinghao Sun, Chenji Wang & Haojie Huang
Bromodomain and extraterminal domain (BET) protein inhibitors are emerging as promising anticancer therapies. The gene encoding the E3 ubiquitin ligase substrate-binding adaptor speckle-type POZ protein (SPOP) is the most frequently mutated in prima...
Source: Nature Medicine - August 14, 2017 Category: General Medicine Authors: Pingzhao Zhang Dejie Wang Yu Zhao Shancheng Ren Kun Gao Zhenqing Ye Shangqian Wang Chun-Wu Pan Yasheng Zhu Yuqian Yan Yinhui Yang Di Wu Yundong He Jun Zhang Daru Lu Xiuping Liu Long Yu Shimin Zhao Yao Li Dong Lin Yuzhuo Wang Liguo Wang Yu Chen Yinghao Sun Tags: Letter Source Type: research
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors
Nature Medicine 23, 1046 (2017).
doi:10.1038/nm.4372
Authors: Hana Janouskova, Geniver El Tekle, Elisa Bellini, Namrata D Udeshi, Anna Rinaldi, Anna Ulbricht, Tiziano Bernasocchi, Gianluca Civenni, Marco Losa, Tanya Svinkina, Craig M Bielski, Gregory V Kryukov, Luciano Cascione, Sara Napoli, Radoslav I Enchev, David G Mutch, Michael E Carney, Andrew Berchuck, Boris J N Winterhoff, Russell R Broaddus, Peter Schraml, Holger Moch, Francesco Bertoni, Carlo V Catapano, Matthias Peter, Steven A Carr, Levi A Garraway, Peter J Wild & Jean-Philippe P Theurillat (Source: Nature Medicine)
Source: Nature Medicine - August 14, 2017 Category: General Medicine Authors: Hana Janouskova Geniver El Tekle Elisa Bellini Namrata D Udeshi Anna Rinaldi Anna Ulbricht Tiziano Bernasocchi Gianluca Civenni Marco Losa Tanya Svinkina Craig M Bielski Gregory V Kryukov Luciano Cascione Sara Napoli Radoslav I Enchev David G Mutch Michae Tags: Article Source Type: research
Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Nature Medicine 23, 1004 (2017).
doi:10.1038/nm0817-1004c
Authors: Ahmet Zehir, Ryma Benayed, Ronak H Shah, Aijazuddin Syed, Sumit Middha, Hyunjae R Kim, Preethi Srinivasan, Jianjiong Gao, Debyani Chakravarty, Sean M Devlin, Matthew D Hellmann, David A Barron, Alison M Schram, Meera Hameed, Snjezana Dogan, Dara S Ross, Jaclyn F Hechtman, Deborah F DeLair, JinJuan Yao, Diana L Mandelker, Donavan T Cheng, Raghu Chandramohan, Abhinita S Mohanty, Ryan N Ptashkin, Gowtham Jayakumaran, Meera Prasad, Mustafa H Syed, Anoop Balakrishnan Rema, Zhen Y Liu, Khedoudja Nafa, Laetitia Borsu, Justyna Sadowska, Jacklyn Casanova, Ru...
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Tags: Erratum Source Type: research
Corrigendum: Is autoimmunity the Achilles' heel of cancer immunotherapy?
Nature Medicine 23, 1004 (2017).
doi:10.1038/nm0817-1004b
Authors: Carl H June, Jeremy T Warshauer & Jeffrey A Bluestone (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Carl H June Jeremy T Warshauer Jeffrey A Bluestone Tags: Corrigendum Source Type: research
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Nature Medicine 23, 1004 (2017).
doi:10.1038/nm0817-1004a
Authors: Jenny Aurielle B Babon, Megan E DeNicola, David M Blodgett, Inne Crèvecoeur, Thomas S Buttrick, René Maehr, Rita Bottino, Ali Naji, John Kaddis, Wassim Elyaman, Eddie A James, Rachana Haliyur, Marcela Brissova, Lut Overbergh, Chantal Mathieu, Thomas Delong, Kathryn Haskins, Alberto Pugliese, Martha Campbell-Thompson, Clayton Mathews, Mark A Atkinson, Alvin C Powers, David M Harlan & Sally C Kent (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Jenny Aurielle B Babon Megan E DeNicola David M Blodgett Inne Cr è vecoeur Thomas S Buttrick Ren é Maehr Rita Bottino Ali Naji John Kaddis Wassim Elyaman Eddie A James Rachana Haliyur Marcela Brissova Lut Overbergh Chantal Mathieu Thomas Delong Kathryn Tags: Corrigendum Source Type: research
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
Nature Medicine 23, 917 (2017).
doi:10.1038/nm.4381
Authors: Benjamin Blasco, Didier Leroy & David A Fidock (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Benjamin Blasco Didier Leroy David A Fidock Tags: Review Source Type: research
Resolving a chronic inflammation mystery
Nature Medicine 23, 914 (2017).
doi:10.1038/nm.4384
Authors: Ben Roediger & Wolfgang Weninger
Using interleukin (IL)-9-deficient mice, Rauber and colleagues unveil a crucial role for group 2 innate lymphoid cells (ILC2s) in the resolution phase of arthritic inflammation, opening up new therapeutic avenues for chronic inflammatory disease. (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Ben Roediger Wolfgang Weninger Tags: News and Views Source Type: research
A three-drug combination to treat BRAF-mutant cancers
Nature Medicine 23, 913 (2017).
doi:10.1038/nm.4382
Authors: Ari J Firestone & Jeff Settleman
A new study that uses a triple-drug combination to overcome a major mechanism of drug resistance in cancer provides insights into the evolutionary paths taken by tumors in the face of selective pressure. (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Ari J Firestone Jeff Settleman Tags: News and Views Source Type: research
Calculated risk: a new single-nucleotide polymorphism linked to severe influenza disease
Nature Medicine 23, 911 (2017).
doi:10.1038/nm.4383
Authors: Amie J Eisfeld & Yoshihiro Kawaoka
Clear links between human genes and susceptibility to influenza disease are scarce. A recent study uncovers a gene variant coupled to severe influenza, and shows how it hampers the expression of an antiviral gene that is key to immune cell survival. (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Amie J Eisfeld Yoshihiro Kawaoka Tags: News and Views Source Type: research
Breaking through: How researchers are gaining entry into barricaded bacteria
Nature Medicine 23, 907 (2017).
doi:10.1038/nm0817-907
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
