Stimulus package
Nature Medicine 24, 247 (2018).
doi:10.1038/nm.4515
Therapies for Alzheimer's disease and other neurodegenerative diseases are desperately needed. Yet, a string of disappointments in the neurodegenerative therapy space has meant that several companies over the years have ended their investment in the field. Some companies have diversified their research and development (R&D) models to hedge their bets. Maintaining this diversity to bring down the silos between big pharma and smaller research teams may be necessary to jumpstart and sustain progress in combatting neurodegenerative conditions. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Tags: Editorial Source Type: research
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
Nature Medicine 24, 512 (2018).
doi:10.1038/nm.4497
Authors: Leila Dardaei, Hui Qin Wang, Manrose Singh, Paul Fordjour, Katherine X Shaw, Satoshi Yoda, Grainne Kerr, Kristine Yu, Jinsheng Liang, Yichen Cao, Yan Chen, Michael S Lawrence, Adam Langenbucher, Justin F Gainor, Luc Friboulet, Ibiayi Dagogo-Jack, David T Myers, Emma Labrot, David Ruddy, Melissa Parks, Dana Lee, Richard H DiCecca, Susan Moody, Huaixiang Hao, Morvarid Mohseni, Matthew LaMarche, Juliet Williams, Keith Hoffmaster, Giordano Caponigro, Alice T Shaw, Aaron N Hata, Cyril H Benes, Fang Li & Jeffrey A Engelman
Most anaplastic lymphoma kinase (A...
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Leila Dardaei Hui Qin Wang Manrose Singh Paul Fordjour Katherine X Shaw Satoshi Yoda Grainne Kerr Kristine Yu Jinsheng Liang Yichen Cao Yan Chen Michael S Lawrence Adam Langenbucher Justin F Gainor Luc Friboulet Ibiayi Dagogo-Jack David T Myers Emma Labro Tags: Letter Source Type: research
Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse
Nature Medicine 24, 474 (2018).
doi:10.1038/nm.4505
Authors: Zinaida Good, Jolanda Sarno, Astraea Jager, Nikolay Samusik, Nima Aghaeepour, Erin F Simonds, Leah White, Norman J Lacayo, Wendy J Fantl, Grazia Fazio, Giuseppe Gaipa, Andrea Biondi, Robert Tibshirani, Sean C Bendall, Garry P Nolan & Kara L Davis (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Zinaida Good Jolanda Sarno Astraea Jager Nikolay Samusik Nima Aghaeepour Erin F Simonds Leah White Norman J Lacayo Wendy J Fantl Grazia Fazio Giuseppe Gaipa Andrea Biondi Robert Tibshirani Sean C Bendall Garry P Nolan Kara L Davis Tags: Article Source Type: research
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia
Nature Medicine 24, 450 (2018).
doi:10.1038/nm.4499
Authors: Bin Zhang, Le Xuan Truong Nguyen, Ling Li, Dandan Zhao, Bijender Kumar, Herman Wu, Allen Lin, Francesca Pellicano, Lisa Hopcroft, Yu-Lin Su, Mhairi Copland, Tessa L Holyoake, Calvin J Kuo, Ravi Bhatia, David S Snyder, Haris Ali, Anthony S Stein, Casey Brewer, Huafeng Wang, Tinisha McDonald, Piotr Swiderski, Estelle Troadec, Ching-Cheng Chen, Adrienne Dorrance, Vinod Pullarkat, Yate-Ching Yuan, Danilo Perrotti, Nadia Carlesso, Stephen J Forman, Marcin Kortylewski, Ya-Huei Kuo & Guido Marcucci (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Bin Zhang Le Xuan Truong Nguyen Ling Li Dandan Zhao Bijender Kumar Herman Wu Allen Lin Francesca Pellicano Lisa Hopcroft Yu-Lin Su Mhairi Copland Tessa L Holyoake Calvin J Kuo Ravi Bhatia David S Snyder Haris Ali Anthony S Stein Casey Brewer Huafeng Wang Tags: Article Source Type: research
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy
Nature Medicine 24, 427 (2018).
doi:10.1038/nm.4500
Authors: Nisha M Badders, Ane Korff, Helen C Miranda, Pradeep K Vuppala, Rebecca B Smith, Brett J Winborn, Emmanuelle R Quemin, Bryce L Sopher, Jennifer Dearman, James Messing, Nam Chul Kim, Jennifer Moore, Brian D Freibaum, Anderson P Kanagaraj, Baochang Fan, Heather Tillman, Ping-Chung Chen, Yingzhe Wang, Burgess B Freeman III, Yimei Li, Hong Joo Kim, Albert R La Spada & J Paul Taylor (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Nisha M Badders Ane Korff Helen C Miranda Pradeep K Vuppala Rebecca B Smith Brett J Winborn Emmanuelle R Quemin Bryce L Sopher Jennifer Dearman James Messing Nam Chul Kim Jennifer Moore Brian D Freibaum Anderson P Kanagaraj Baochang Fan Heather Tillman Pi Tags: Article Source Type: research
Nociceptor sensory neurons suppress neutrophil and γ δ T cell responses in bacterial lung infections and lethal pneumonia
Nature Medicine 24, 417 (2018).
doi:10.1038/nm.4501
Authors: Pankaj Baral, Benjamin D Umans, Lu Li, Antonia Wallrapp, Meghna Bist, Talia Kirschbaum, Yibing Wei, Yan Zhou, Vijay K Kuchroo, Patrick R Burkett, Bryan G Yipp, Stephen D Liberles & Isaac M Chiu (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Pankaj Baral Benjamin D Umans Lu Li Antonia Wallrapp Meghna Bist Talia Kirschbaum Yibing Wei Yan Zhou Vijay K Kuchroo Patrick R Burkett Bryan G Yipp Stephen D Liberles Isaac M Chiu Tags: Article Source Type: research
Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women
Nature Medicine 24, 491 (2018).
doi:10.1038/nm.4506
Authors: Lyle R McKinnon, Lenine J Liebenberg, Nonhlanhla Yende-Zuma, Derseree Archary, Sinaye Ngcapu, Aida Sivro, Nico Nagelkerke, Jose Gerardo Garcia Lerma, Angela D Kashuba, Lindi Masson, Leila E Mansoor, Quarraisha Abdool Karim, Salim S Abdool Karim & Jo-Ann S Passmore (Source: Nature Medicine)
Source: Nature Medicine - February 26, 2018 Category: General Medicine Authors: Lyle R McKinnon Lenine J Liebenberg Nonhlanhla Yende-Zuma Derseree Archary Sinaye Ngcapu Aida Sivro Nico Nagelkerke Jose Gerardo Garcia Lerma Angela D Kashuba Lindi Masson Leila E Mansoor Quarraisha Abdool Karim Salim S Abdool Karim Jo-Ann S Passmore Tags: Article Source Type: research
Restorative effects of human neural stem cell grafts on the primate spinal cord
Nature Medicine 24, 484 (2018).
doi:10.1038/nm.4502
Authors: Ephron S Rosenzweig, John H Brock, Paul Lu, Hiromi Kumamaru, Ernesto A Salegio, Ken Kadoya, Janet L Weber, Justine J Liang, Rod Moseanko, Stephanie Hawbecker, J Russell Huie, Leif A Havton, Yvette S Nout-Lomas, Adam R Ferguson, Michael S Beattie, Jacqueline C Bresnahan & Mark H Tuszynski (Source: Nature Medicine)
Source: Nature Medicine - February 26, 2018 Category: General Medicine Authors: Ephron S Rosenzweig John H Brock Paul Lu Hiromi Kumamaru Ernesto A Salegio Ken Kadoya Janet L Weber Justine J Liang Rod Moseanko Stephanie Hawbecker J Russell Huie Leif A Havton Yvette S Nout-Lomas Adam R Ferguson Michael S Beattie Jacqueline C Bresnahan Tags: Article Source Type: research
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
Nature Medicine 24, 497 (2018).
doi:10.1038/nm.4493
Authors: Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg Keaney, Michael Thomas, Anant A Agrawal, Benjamin Caleb, Alfredo Csibi, Eckley Sean, Peter Fekkes, Craig Karr, Virginia Klimek, George Lai, Linda Lee, Pavan Kumar, Stanley Chun-Wei Lee, Xiang Liu, Crystal Mackenzie, Carol Meeske, Yoshiharu Mizui, Eric Padron, Eunice Park, Ermira Pazolli, Shouyong Peng, Sudeep Prajapati, Justin Taylor, Teng Teng, John Wang, Markus Warmuth, Huilan Yao, Lihua Yu, Ping Zhu, Omar Abdel-Wahab, Peter G Smith & Silvia Buonamici
Genomic analyses of cancer have i...
Source: Nature Medicine - February 19, 2018 Category: General Medicine Authors: Michael Seiler Akihide Yoshimi Rachel Darman Betty Chan Gregg Keaney Michael Thomas Anant A Agrawal Benjamin Caleb Alfredo Csibi Eckley Sean Peter Fekkes Craig Karr Virginia Klimek George Lai Linda Lee Pavan Kumar Stanley Chun-Wei Lee Xiang Liu Crystal Ma Tags: Letter Source Type: research
A histone deacetylase 3 – dependent pathway delimits peripheral myelin growth and functional regeneration
Nature Medicine 24, 338 (2018).
doi:10.1038/nm.4483
Authors: Xuelian He, Liguo Zhang, Luis F Queme, Xuezhao Liu, Andrew Lu, Ronald R Waclaw, Xinran Dong, Wenhao Zhou, Grahame Kidd, Sung-Ok Yoon, Andres Buonanno, Joshua B Rubin, Mei Xin, Klaus-Armin Nave, Bruce D Trapp, Michael P Jankowski & Q Richard Lu (Source: Nature Medicine)
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Xuelian He Liguo Zhang Luis F Queme Xuezhao Liu Andrew Lu Ronald R Waclaw Xinran Dong Wenhao Zhou Grahame Kidd Sung-Ok Yoon Andres Buonanno Joshua B Rubin Mei Xin Klaus-Armin Nave Bruce D Trapp Michael P Jankowski Q Richard Lu Tags: Article Source Type: research
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
Nature Medicine 24, 304 (2018).
doi:10.1038/nm.4479
Authors: Tamer Sallam, Marius Jones, Brandon J Thomas, Xiaohui Wu, Thomas Gilliland, Kevin Qian, Ascia Eskin, David Casero, Zhengyi Zhang, Jaspreet Sandhu, David Salisbury, Prashant Rajbhandari, Mete Civelek, Cynthia Hong, Ayaka Ito, Xin Liu, Bence Daniel, Aldons J Lusis, Julian Whitelegge, Laszlo Nagy, Antonio Castrillo, Stephen Smale & Peter Tontonoz (Source: Nature Medicine)
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Tamer Sallam Marius Jones Brandon J Thomas Xiaohui Wu Thomas Gilliland Kevin Qian Ascia Eskin David Casero Zhengyi Zhang Jaspreet Sandhu David Salisbury Prashant Rajbhandari Mete Civelek Cynthia Hong Ayaka Ito Xin Liu Bence Daniel Aldons J Lusis Julian Wh Tags: Article Source Type: research
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
Nature Medicine 24, 282 (2018).
doi:10.1038/nm.4484
Authors: Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, Sandra Duquesne, Annette Schmitt-Graeff, Lena Osswald, Kai-Li Yan, Arnim Weber, Sonia Tugues, Sabine Spath, Dietmar Pfeifer, Marie Follo, Rainer Claus, Michael Lübbert, Christoph Rummelt, Hartmut Bertz, Ralph Wäsch, Johanna Haag, Andrea Schmidts, Michael Schultheiss, Dominik Bettinger, Robert Thimme, Evelyn Ullrich, Yakup Tanriver, Giang Lam ...
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A M ü ller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Tags: Article Source Type: research
DKK2 imparts tumor immunity evasion through β -catenin-independent suppression of cytotoxic immune-cell activation
Nature Medicine 24, 262 (2018).
doi:10.1038/nm.4496
Authors: Qian Xiao, Jibo Wu, Wei-Jia Wang, Shiyang Chen, Yingxia Zheng, Xiaoqing Yu, Katrina Meeth, Mahnaz Sahraei, Alfred L M Bothwell, Lieping Chen, Marcus Bosenberg, Jianfeng Chen, Veronika Sexl, Le Sun, Lin Li, Wenwen Tang & Dianqing Wu (Source: Nature Medicine)
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Qian Xiao Jibo Wu Wei-Jia Wang Shiyang Chen Yingxia Zheng Xiaoqing Yu Katrina Meeth Mahnaz Sahraei Alfred L M Bothwell Lieping Chen Marcus Bosenberg Jianfeng Chen Veronika Sexl Le Sun Lin Li Wenwen Tang Dianqing Wu Tags: Article Source Type: research
Macrophages and platelets join forces to release kidney-damaging DNA traps
Nature Medicine 24, 128 (2018).
doi:10.1038/nm.4486
Author: Dominik Hartl
A recent study in mice dissects the mechanisms through which muscle damage leads to kidney dysfunction and identifies macrophage extracellular trap (MET) formation as a new pathogenic driver and potential therapeutic target. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Dominik Hartl Tags: News and Views Source Type: research
Selective enhancer changes in osteosarcoma lung metastasis
Nature Medicine 24, 126 (2018).
doi:10.1038/nm.4487
Author: Heinrich Kovar
A recent study investigates the contribution of epigenomic plasticity to lung metastasis in osteosarcoma. Changes in the enhancer landscape were found to be nonrandom and driven by selective forces in the microenvironment. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Heinrich Kovar Tags: News and Views Source Type: research
