Engineering MeCP2 to spy on its targets

Nature Medicine 23, 1120 (2017). doi:10.1038/nm.4425 Authors: Patricia M Horvath & Lisa M Monteggia A new mouse model of Rett syndrome, in which MECP2 can be selectively biotinylated, allows for the investigation of cell-specific effects of Rett-causing mutations on gene expression, particularly in female mice.
Source: Nature Medicine - Category: General Medicine Authors: Tags: News and Views Source Type: research