Cataractogenic potential of quetiapine versus risperidone in the long-term treatment of patients with schizophrenia or schizoaffective disorder: A randomized, open-label, ophthalmologist-masked, flexible-dose, non-inferiority trial
Clinical observations indicate no cataractogenic potential for quetiapine, in contrast to studies in laboratory animals. This randomized, non-inferiority study compared changes in lens opacity during long-term treatment with quetiapine versus risperidone. Patients with schizophrenia or schizoaffective disorder participated in the 2-year, randomized, multicentre, open-label, ophthalmologist-masked, flexible-dose, parallel-group study. Two ophthalmologists examined each patient 6-monthly for presence of nuclear opalescence (N) and cortical (C) or posterior subcapsular opacification (P), according to the lens opacities classi...
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Laties, A. M., Flach, A. J., Baldycheva, I., Rak, I., Earley, W., Pathak, S. Tags: Articles Source Type: research
LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects
Conclusions:
LSD administered in a medically supervised psychotherapeutic setting can be safe and generate lasting benefits in patients with a life-threatening disease. Explanatory models for the therapeutic effects of LSD warrant further study. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Gasser, P., Kirchner, K., Passie, T. Tags: Articles Source Type: research
A comparison of impulsivity, depressive symptoms, lifetime stress and sensation seeking in healthy controls versus participants with cocaine or methamphetamine use disorders
Previous research has focused on developing theories of addiction that may explain behavior in cocaine- and methamphetamine-dependent individuals. The primary goal of this report was to compare and contrast the prevalence of self-reported measures of impulsivity, depression, lifetime stress and sensation-seeking in healthy controls versus individuals with cocaine or methamphetamine use disorders. Twenty-nine individuals with cocaine use disorders and 31 individuals with methamphetamine use disorders were matched with 31 healthy control participants on several demographic variables. All participants were administered behavi...
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Mahoney, J. J., Thompson-Lake, D. G., Cooper, K., Verrico, C. D., Newton, T. F., De La Garza, R. Tags: Articles Source Type: research
Considerations on the role of buprenorphine in recovery from heroin addiction from a UK perspective
The United Kingdom Drug Strategy emphasises recovery as a key focus in the treatment of drug dependence. A framework for recovery is defined in the Recovery-Orientated Drug Treatment report, written by an expert working group, and comprises four key phases: engagement and stabilisation, including the establishment of treatment goals; preparation for change, involving engagement in psychosocial and pharmacological interventions; active change, including detoxification and medical withdrawal; and completion, including interventions that strengthen community integration. A body of evidence supports the benefits of buprenorphi...
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Nutt, D. J. Tags: Articles Source Type: research
Services for young people with attention deficit/hyperactivity disorder transitioning from child to adult mental health services: A national survey of mental health trusts in England
This article presents results from a national survey of 36 mental health National Health Service (NHS) trusts across England, the findings indicate a lack of accurate data on the number of young people with ADHD transitioning to, and being seen by, adult services. Less than half of the trusts had a specialist adult ADHD service and in only a third of the trusts were there specific commissioning arrangements for adult ADHD. Half of the trusts reported that young people with ADHD were prematurely discharged from child and adolescent mental health services (CAMHS) because there were no suitable adult services. There was also ...
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Hall, C. L., Newell, K., Taylor, J., Sayal, K., Hollis, C. Tags: Articles Source Type: research
Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD
Conclusion:
We could replicate and extend previous findings showing altered NOx - levels in BPD and an influence of NOS3 rs2070744 on NOS3 expression and NOx - concentration. Together, these data point to a role of the nitrinergic pathway in BPD. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Kittel-Schneider, S., Reuss, M., Meyer, A., Weber, H., Gessner, A., Leistner, C., Kopf, J., Schmidt, B., Hempel, S., Volkert, J., Lesch, K.-P., Reif, A. Tags: Articles Source Type: research
Predicting methylphenidate response in attention deficit hyperactivity disorder: A preliminary study
Methylphenidate (MPH) is established as the main pharmacological treatment for patients with attention deficit hyperactivity disorder (ADHD). Whilst MPH is generally a highly effective treatment, not all patients respond, and some experience adverse reactions. Currently, there is no reliable method to predict how patients will respond, other than by exposure to a trial of medication. In this preliminary study, we sought to investigate whether an accurate predictor of clinical response to methylphenidate could be developed for individual patients, using sociodemographic, clinical and neuropsychological measures. Of the 43 b...
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Johnston, B. A., Coghill, D., Matthews, K., Steele, J. D. Tags: Articles Source Type: research
Pharmacological treatment of attention deficit hyperactivity disorder with co-morbid drug dependence
Conclusions:
The efficacy of pharmacological interventions for co-occurring ADHD and SUD has been little investigated. Mixed results were obtained: while pharmacological interventions improved ADHD symptoms, no beneficial effect on drug abstinence or on treatment discontinuation was noted. The strength of the recommendation of pharmacological treatment for co-occurring ADHD and SUD is therefore modest. The study was registered with the international prospective register of systematic reviews (PROSPERO): CRD 4212003414. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Cunill, R., Castells, X., Tobias, A., Capella, D. Tags: Articles Source Type: research
Safety and tolerability of atomoxetine in treatment of attention deficit hyperactivity disorder in adult patients: An integrated analysis of 15 clinical trials
The safety profile of atomoxetine in the treatment of attention deficit hyperactivity disorder has been studied in many clinical trials. We performed an integrated safety analysis of 15 clinical trials in adults with attention deficit hyperactivity disorder. The analysis pooled patient data into three groups: acute placebo-controlled trials; long-term placebo-controlled trials; all trials. In total, 4829 adults (18–77 years, median: 36 years) were exposed to atomoxetine. Statistically significantly more atomoxetine-treated than placebo-treated patients experienced treatment-emergent adverse events (81.3% vs. 68.3% ac...
Source: Journal of Psychopharmacology - December 10, 2014 Category: Psychiatry Authors: Camporeale, A., Porsdal, V., De Bruyckere, K., Tanaka, Y., Upadhyaya, H., Deix, C., Deberdt, W. Tags: Articles Source Type: research
Erratum
for Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus by Elena Dale, Hong Zhang, Steven C Leiser, Yixin Xiao, Dunguo Lu, Charles R Yang, Niels Plath, and Connie Sanchez. Journal of Psychopharmacology October 2014 28: 891–902, doi:10.1177/0269881114543719.
The publisher would like to apologize for the error that occurred in this paper which included Figure 6 in black and white. It should have been published in colour as in the online version. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Tags: Erratum Source Type: research
Corrigendum
for ‘The impact of nicotine lozenges and stimulus expectancies on cigarette craving’ by Hera E Schlagintweit, Kimberley P Good, and Sean P Barrett. Journal of Psychopharmacology 28: 773-779. DOI: 10.1177/0269881113519508 .
The following sentence was erroneously omitted. It should have been included in the paragraph under the heading ‘Craving’ on page 776:
A significant main effect of Told was observed for factor 2 craving [F(1,61.92)=8.22, p=0.006], with lower withdrawal-related craving when participants were told they received a nicotine lozenge (M=14.09, SE=0.8...
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Tags: Corrigendum Source Type: research
Reply to Letter to the Editor
(Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Authors: Aiff, H., Attman, P.-O., Bendz, H., Ramsauer, B., Schon, S., Svedlund, J. Tags: Letter to the Editors Source Type: research
Response to "The impact of modern treatment principles may have eliminated lithium-induced renal failure" Aiff et al. 2014
(Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Authors: Werneke, U., Ott, M. Tags: Letter to the Editors Source Type: research
Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine
Dyspnea, ‘hunger for air’, and the urge to flee are the cardinal symptoms of respiratory-type panic attacks. Patients also show baseline respiratory abnormalities and a higher rate of comorbid and antecedent respiratory diseases. Panic attacks are also precipitated by both the infusion of 0.5 M sodium lactate and the inhalation of 5–7% carbon dioxide (CO2) in predisposed patients, but not in healthy volunteers nor patients without panic disorder. Further studies show that patients with panic are also hyper-responsive to hypoxia. These and other observations led Klein (1993) to suggest that clinical panic ...
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Authors: Schimitel, F. G., Muller, C. J. T., Tufik, S., Schenberg, L. C. Tags: Short Reports Source Type: research
The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition
There is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to the effects of chronic stress and treatment with most classes of antidepressant drugs, being involved in the onset and recovery from depression. However, the effects of antidepressants that act through the selective inhibition of monoamine oxidase subtype A (MAO-A) in these phenomena are still largely unknown. In the present study, adult neurogenesis and neuronal morphology were examined in the hippocampus of rats exposed to chronic mild stress (CMS) and treated with the selecti...
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Authors: Morais, M., Santos, P. A., Mateus-Pinheiro, A., Patricio, P., Pinto, L., Sousa, N., Pedroso, P., Almeida, S., Filipe, A., Bessa, J. M. Tags: Short Reports Source Type: research
