Recreational 3,4-methylenedioxy-N-methylamphetamine (MDMA) or 'ecstasy' and self-focused compassion: Preliminary steps in the development of a therapeutic psychopharmacology of contemplative practices
3,4-methylenedioxy-N-methylamphetamine (MDMA) produces diverse pro-social effects. Cognitive training methods rooted in Eastern contemplative practices also produce these effects through the development of a compassionate mindset. Given this similarity, we propose that one potential mechanism of action of MDMA in psychotherapy is through enhancing effects on intrapersonal attitudes (i.e. pro-social attitudes towards the self). We provide a preliminary test of this idea. Recreational MDMA (ecstasy) users were tested on two occasions, having consumed or not consumed ecstasy. Self-critical and self-compassionate responses to ...
Source: Journal of Psychopharmacology - September 21, 2015 Category: Psychiatry Authors: Kamboj, S. K., Kilford, E. J., Minchin, S., Moss, A., Lawn, W., Das, R. K., Falconer, C. J., Gilbert, P., Curran, H. V., Freeman, T. P. Tags: Original Papers Source Type: research
The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description
We describe herein the study design, main aims, recruitment numbers, sample characteristics, and explain the test hypotheses and anticipated study outputs. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 21, 2015 Category: Psychiatry Authors: Paterson, L. M., Flechais, R. S., Murphy, A., Reed, L. J., Abbott, S., Boyapati, V., Elliott, R., Erritzoe, D., Ersche, K. D., Faluyi, Y., Faravelli, L., Fernandez-Egea, E., Kalk, N. J., Kuchibatla, S. S., McGonigle, J., Metastasio, A., Mick, I., Nestor, Tags: Original Papers Source Type: research
Erratum
Concluding reply. Journal of Psychopharmacology, first published on December 5, 2012 as doi : 0269881112466185c. This version is no longer available. The version of record is published in Vol 27 No 5, DOI 10.1177/0269881112466185. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 21, 2015 Category: Psychiatry Tags: Erratum Source Type: research
Erratum
Emma Robinson
Can a single animal model ever provide a valid approach to study clinical depression? A response to: The failure of the antidepressant drug discovery process is systemic (Hendrie CA and Pickles AR). Journal of Psychopharmacology, first published on December 5, 2012 as doi : 0269881112466185b. This version is no longer available. The version of record is published in Vol 27 No 5, DOI 10.1177/0269881112466185. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 21, 2015 Category: Psychiatry Tags: Erratum Source Type: research
Erratum
S Clare Stanford
Beating the recession in preclinical measures of antidepression: A response to: The failure of the antidepressant drug discovery process is systemic (Hendrie CA and Pickles AR). Journal of Psychopharmacology, first published on December 5, 2012 as doi : 0269881112466185a. This version is no longer available. The version of record is published in Vol 27 No 5, DOI 10.1177/0269881112466185. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 21, 2015 Category: Psychiatry Tags: Erratum Source Type: research
Erratum
Anne Connolly, David Taylor, Anna Sparshatt, and Victoria Cornelius
Antipsychotic prescribing in Black and White hospitalised patients. Journal of Psychopharmacology, first published on December 8, 2010 as doi: 10.1177/0269881110387841. This version is no longer available. The version of record is published in Vol 25 No 5, DOI 10.1177/0269881109387841. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 21, 2015 Category: Psychiatry Tags: Erratum Source Type: research
Corrigendum
Harms and benefits associated with psychoactive drugs: findings of an international survey of active drug users by Celia JA Morgan, Louise A Noronha, Mark Muetzelfeldt, Amanda Feilding, and H Valerie Curran Journal of Psychopharmacology 27: 497-506. DOI: 10.1177/0269881113477744.
In the print issue of the journal Dr Amanda Feilding’s name was mis-spelled as Fielding. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 21, 2015 Category: Psychiatry Tags: Corrigendum Source Type: research
Olanzapine and risperidone plasma concentration therapeutic drug monitoring: A feasibility study
Conclusion:
TDM can be implemented as part of routine clinical practice for both drugs. However, the lack of robust supporting evidence for or against antipsychotic TDM has probably led to a lack of enthusiasm for and interest in the results. Nevertheless, the advent of less invasive measures and the targeting of patients who might be more likely to benefit may facilitate uptake. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: Law, S., Gudbrandsen, M., Magill, N., Sweetman, I., Rose, D., Landau, S., Flanagan, R. J., David, A. S., Patel, M. X. Tags: Short Report Source Type: research
Efficacy of drug treatment for acute mania differs across geographic regions: An individual patient data meta-analysis of placebo-controlled studies
The objective of this study was to examine the efficacy of treatment in acute mania in bipolar disorder across regions and to explain potential differences by differences in patient characteristics. We performed a meta-analysis of individual patient data from 12 registration studies for the indication acute manic episode of bipolar disorder. Patients (n = 3207) were classified into one of three geographic regions: Europe (n = 981), USA (n = 1270), and other regions (n = 956). Primary outcome measures were mean symptom change score on the Young Mania Rating Scale (YMRS) from baseline to endpoint and responder status (50% im...
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: Welten, C. C., Koeter, M., Wohlfarth, T., Storosum, J., van den Brink, W., Gispen-de Wied, C., Leufkens, H., Denys, D. Tags: Original Papers Source Type: research
Paliperidone palmitate in non-acute patients with schizophrenia previously unsuccessfully treated with risperidone long-acting therapy or frequently used conventional depot antipsychotics
PALMFlexS, a prospective multicentre, open-label, 6-month, phase IIIb interventional study, explored tolerability, safety and treatment response in adults (n = 231) with non-acute but symptomatic schizophrenia switching to flexibly dosed paliperidone palmitate (PP) after unsuccessful treatment with risperidone long-acting injectable therapy (RLAT) or conventional depot antipsychotics (APs). Treatment response was measured by change in Positive and Negative Syndrome Scale (PANSS) total score from baseline (BL) to last-observation-carried-forward (LOCF) endpoint (EP). Safety and tolerability assessments included Extrapyramid...
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: Schreiner, A., Bergmans, P., Cherubin, P., Keim, S., Llorca, P.-M., Cosar, B., Petralia, A., Corrivetti, G., Hargarter, L. Tags: Original Papers Source Type: research
A comparison of risperidone and haloperidol for the risk of ischemic stroke in the elderly: a propensity score-matched cohort analysis
Conclusions:
The evidence showed that haloperidol should be prescribed in the elderly with caution. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: Shin, J.-Y., Choi, N.-K., Lee, J., Park, M.-J., Lee, S. H., Park, B.-J. Tags: Original Papers Source Type: research
Plasma BDNFs level initially and post treatment in acute mania: comparison between ECT and atypical antipsychotic treatment and healthy controls
Conclusions:
In this study, for the first time we revealed a significant decrease in BDNF levels after ECT sessions in acute manic patients. Besides clinical remission after treatment in acute mania, the decrement in BDNF levels does not seem to be related to clinical response. Thus cumulative effects of mood episodes for the ongoing decrease in BDNF levels might be borne in mind despite the achievement of remission and/or more time being required for an increase in BDNF levels after treatment. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: Karamustafalioglu, N., Genc, A., Kalelioglu, T., Tasdemir, A., Umut, G., Incir, S., Akkus, M., Emul, M. Tags: Original Papers Source Type: research
Treatment resistant or resistant to treatment? Antipsychotic plasma levels in patients with poorly controlled psychotic symptoms
A large proportion of individuals with schizophrenia show an inadequate response to treatment with antipsychotics. It can be unclear whether this is secondary to subtherapeutic antipsychotic plasma levels or to medication ineffectiveness. The purpose of the present study was to determine the extent of subtherapeutic antipsychotic plasma levels in a group of patients clinically identified as treatment-resistant. In addition we investigated the frequency of antipsychotic plasma level monitoring in standard clinical practice. Antipsychotic plasma levels were measured in 36 patients identified as having treatment-resistant sch...
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: McCutcheon, R., Beck, K., Bloomfield, M. A., Marques, T. R., Rogdaki, M., Howes, O. D. Tags: Original Papers Source Type: research
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs
Individual variation in pharmacokinetics of psychotropic drugs, particularly metabolism, is an important factor to consider in pharmacological treatment in psychiatry. A large proportion of this variance is still not accounted for, but evidence so far suggests the involvement of genetic factors. We performed a genome-wide association study (GWAS) with concentration dose ratio (CDR) as sub-phenotype to assess metabolism rate of psychotropic drugs in a homogenous Norwegian sample of 1334 individuals diagnosed with a severe mental disorder. The GWAS revealed one genome-wide significant marker (rs16935279, p-value=3.95x10&ndas...
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: Athanasiu, L., Smorr, L.-L. H., Tesli, M., Rossberg, J. I., Sonderby, I. E., Spigset, O., Djurovic, S., Andreassen, O. A. Tags: Original Papers Source Type: research
Further evidence for the association of the NPSR1 gene A/T polymorphism (Asn107Ile) with impulsivity and hyperactivity
Administration of neuropeptide S (NPS) elicits anxiolysis, arousal and higher activity in rodents. In humans, the NPS receptor (NPSR1) gene rs324981 A/T (Asn107Ile) polymorphism is associated with fear responses and anxiety. We have recently revealed an association of NPSR1 with impulsivity-related traits and psychopathology. In the present study the association of the NPSR1 genotype with impulsivity and attention-deficit/hyperactivity disorder (ADHD)-related symptoms was re-examined in two independent non-clinical cohorts. We used self-reports of two population-derived samples of the Estonian Psychobiological Study of Tra...
Source: Journal of Psychopharmacology - July 20, 2015 Category: Psychiatry Authors: Laas, K., Eensoo, D., Paaver, M., Lesch, K.-P., Reif, A., Harro, J. Tags: Original Papers Source Type: research
