Journal of Pharmacy and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Self ‐assembled liposome from core‐sheath chitosan‐based fibres for buccal delivery of carvedilol: formulation, characterization and in vitro and ex vivo buccal absorption
ConclusionsThese researches exhibited this drug delivery system was promising and advantageous for Car buccal delivery. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Jianting Chen, Hao Pan, Hongliang Duan, Wenbin Deng, Fei Zhang, Xinggang Yang, Weisan Pan Tags: Research Paper Source Type: research

Short ‐chain fatty acids oppositely altered expressions and functions of intestinal cytochrome P4503A and P‐glycoprotein and affected pharmacokinetics of verapamil following oral administration to rats
ConclusionsShort ‐chain fatty acids oppositely regulated functions and expressions of intestinal Cyp3a and P‐gp. The downregulation of P‐gp mainly contributed to the increased oral plasma verapamil exposure by SCFAs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Jiaxin Zhang, Qiushi Xie, Weimin Kong, Zhongjian Wang, Shuting Wang, Kaijing Zhao, Yang Chen, Xiaodong Liu, Li Liu Tags: Research Paper Source Type: research

Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin ‐induced gastric mucosal injury: involvement of TFF1‐mediated EGF/EGFR and apoptotic pathways
ConclusionsOur present study demonstrated that TCS ’s gastroprotective effect was closely connected with boosting TFF1 expression, activating TFF1‐mediated EGF/EGFR pathway, thus restraining mitochondrial‐dependent apoptosis, which provided new insights into interpreting its underlying mechanism and promised to act as a candidate drug to treat gastric mucosal injury. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Yuanyuan Zhang, Haiyan Xu, Haibo He, Xiaomei Li, Minlu Feng, Yumin He, Weijie Jiang, Junzhi Wang, Daoxiang Xu, Kun Zou Tags: Research Paper Source Type: research

Population pharmacokinetics of cefuroxime and uptake into hip and spine bone of patients undergoing orthopaedic surgery
ConclusionEven if a majority of patients undergoing hip or spine surgery probably achieved adequate concentrations of cefuroxime, not all patients reached bone concentrations of cefuroxime above a recommended breakpoint for susceptible germs at the time of surgery. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Ulrich Gergs, Lina Becker, Richard Okoniewski, Michael Weiss, Karl ‐Stefan Delank, Joachim Neumann Tags: Research Paper Source Type: research

Anaesthetic benefits of a ternary drug delivery system (Ropivacaine ‐in‐Cyclodextrin‐in‐Liposomes): in‐vitro and in‐vivo evaluation
ConclusionsThese results confirm the suitability of this double ‐carrier system in clinical practice, to decrease the toxicity and prolong the anaesthesia time evoked by RVC. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Ana La ís Nascimento Vieira, Michelle Franz‐Montan, Luís Fernando Cabeça, Eneida de Paula Tags: Research Paper Source Type: research

Effect of GSK ‐137647A, the first non‐carboxylic FFA4 agonist, on the osteogenic and adipogenic differentiation of bone mesenchymal stem cells in db/db mice
ConclusionsAll of these results demonstrated that GSK ‐137647A suppressed the adipogenic differentiation and promoted osteogenic differentiation of BMSCs, which is partly attributed to the increased expression of β‐catenin in wingless/integrated signalling pathway. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 18, 2019 Category: Drugs & Pharmacology Authors: Chunlei Wang, Yanmei Liu, Yuan Pan, Hui Jin Tags: Research Paper Source Type: research

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities
AbstractObjectivesPaeoniflorin, a representative pinane monoterpene glycoside in plants ofPaeoniaceae family, possesses promising anticancer activities on diverse tumours. This paper summarized the advance of Paeoniflorin on cancersin vivo andin vitro, discussed the related molecular mechanisms, as well as suggested some perspectives of the future investigations.Key findingsAnticancer activities of paeoniflorin have been comprehensively investigated, including liver cancer, gastric cancer, breast cancer, lung cancer, pancreatic cancer, colorectal cancer, glioma, bladder cancer and leukaemia. Furthermore, the potential mole...
Source: Journal of Pharmacy and Pharmacology - December 18, 2019 Category: Drugs & Pharmacology Authors: Yongjing Xiang, Qing Zhang, Shujun Wei, Cong Huang, Zhengsheng Li, Yongxiang Gao Tags: Review Source Type: research

Preparation and evaluation of a novel solid dispersion using leucine as carrier
ConclusionsUsing Leu as a carrier produced a SD with good flowability, low hygroscopicity and high bioavailability. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 16, 2019 Category: Drugs & Pharmacology Authors: Xiaojing Xia, Zeng Tan, Yaru Fan, Ying Hu, Jin Deng Tags: Research Paper Source Type: research

Effect of atorvastatin on A β1–42‐induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures
This study was undertaken whether A β‐induced changes of SESN2 and SIRT1 protein expression, autophagy marker LC3II and lysosomal enzyme TPP1 affected by atorvastatin (Western blot) and its possible role in Aβ neurotoxicity (ELISA).Key findings/resultsWe showed that SESN2 and LC3II expressions were elevated, whereas SIRT1 and TPP1 expressions were decreased in the A β1 –42‐exposed human neuroblastoma cells (SH‐SY5Y). Co‐administration of atorvastatin with Aβ1 –42 compensates SESN2 increase and recovers SIRT1 decline by reducing oxidative stress, decreasing SESN2 expression and increasing SIRT1 expression by...
Source: Journal of Pharmacy and Pharmacology - December 16, 2019 Category: Drugs & Pharmacology Authors: Hande Çelik, Hande Karahan, Pelin Kelicen‐Uğur Tags: Research Paper Source Type: research