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Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ ‐induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes
ConclusionKigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Oladapo F. Fagbohun, Babatunde Olawoye, Adedeji N. Ademakinwa, Kehinde A. Jolayemi, Titus A. M. Msagati Tags: Research Paper Source Type: research

Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism
ConclusionsTripterygium wilfordii chronotoxicity was associated with diurnal variations in triptolide pharmacokinetics and circadian expression of hepatic Cyp3a11 regulated by circadian clock. Our findings may have implications for improving TW treatment outcome with a chronotherapeutic approach. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Huan Zhao, Yongbin Tong, Danyi Lu, Baojian Wu Tags: Research Paper Source Type: research

Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra ‐performance liquid chromatography coupled time‐of‐flight mass spectrometry
ConclusionsThis work revealed thein ‐vivo metabolism of FF, and reported the characteristic metabolic reactions of lignans for the first time. It was also provided the foundation for the further investigation on pharmacodynamic components of FF or TCMs containing FF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Feng ‐xiang Zhang, Zi‐ting Li, Chang Li, Min Li, Zhi‐hong Yao, Xin‐sheng Yao, Yi Dai Tags: Research Paper Source Type: research

Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin ‐O‐glucuronide in HeLa1A1 cells
ConclusionsCYP1A1 and CYP2C9, UGT1A1, UGT1A7, UGT1A8 and UGT1A9, and MRP4 all played important roles in the metabolism and disposition of bavachin. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Yang Li, Chunxia Xu, Jinjin Xu, Zifei Qin, Shishi Li, Liufang Hu, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti ‐inflammatory agent and as adjuvant in psoriasis therapy
ConclusionsThe results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: N ícolas de Castro Campos Pinto, Mariana de Souza Ferreira Maciel, Nathalia dos Santos Rezende, Ana Paula do Nascimento Duque, Renata de Freitas Mendes, Jucélia Barbosa Silva, Monique de Rezende Evangelista, Luana Cahon Monteiro, Josiane Mello S Tags: Research Paper Source Type: research

Therapeutic effects of a çaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin
ConclusionsThe therapeutic effect of ASE was similar to that of rosuvastatin in reducing dyslipidemia and hepatic steatosis but was better in reducing oxidative damage and hyperglycaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Thamires Barros Tavares, Izabelle Barcellos Santos, Graziele Freitas Bem, Dayane Teixeira Ognibene, Ana Paula Machado Rocha, Roberto Soares Moura, Angela de Castro Resende, Julio Beltrame Daleprane, Cristiane Aguiar Costa Tags: Research Paper Source Type: research

Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves
ConclusionsA low AMF bioavailability was due to extensive glucuronidation, which was mediated by UGT1A1 and UGT1A3. Glucuronidated AMF metabolites had the same antioxidant but had a lower anticancer activity than that of AMF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Lili Gan, Jiating Ma, Guoquan You, Jinxia Mai, Zhaoyu Wang, Ruopeng Yang, Cong Xie, Jingrao Fei, Lan Tang, Jie Zhao, Zheng Cai, Ling Ye Tags: Research Paper Source Type: research

Umbelliprenin relieves paclitaxel ‐induced neuropathy
ConclusionsUmbelliprenin alleviated neuropathic pain, and decreased serum IL ‐6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Jafar Shahraki, Ramin Rezaee, Sabereh Mohammadzehi Kenar, Samaneh Setoodeh Nezhad, Gholamreza Bagheri, Hosseinali Jahantigh, Konstantinos Tsarouhas, Mahmoud Hashemzaei Tags: Research Paper Source Type: research

Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti ‐apoptotic and antioxidative activity
ConclusionsThis study emphasized the immune ‐modulatory and antioxidative effects of shikonin, which may have an important healing effect on the severity of EAE. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Mehrdad Nasrollahzadeh Sabet, Sajjad Biglari, Hamid Reza Khorram Khorshid, Emran Esmaeilzadeh Tags: Research Paper Source Type: research

Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
ConclusionsBoth drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Mohamed M. Elseweidy, Gehad M. Elnagar, Marwa M.Elsawy, Abdelmoneim A. Ali, Nabila Zein Tags: Research Paper Source Type: research

Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors
ConclusionsCollectively, we would suggest that geniposide may potentially be utilized as an adjunct to existing thiazide and thiazide ‐like diuretics to control hypertension, mainly through inhibiting the activation of the WNK signalling pathway mediated by the estrogen receptor. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Yang Fu, Pei ‐pei Yuan, Yan‐gang Cao, Ying‐ying Ke, Qi Zhang, Ying Hou, Yan‐li Zhang, Wei‐sheng Feng, Xiao‐ke Zheng Tags: Research Paper Source Type: research

Recombinant ling zhi ‐8 enhances Tregs function to restore glycemic control in streptozocin‐induced diabetic rats
ConclusionsThese data suggest that rLZ ‐8 can antagonize STZ‐induced T1D, and its mechanism may be related to inhibit inflammation and enhance Tregs generation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Hongyu Xiao, Zhi Fang, Xueling He, Ping Ding, Yongkai Cao, Shamyuen Chan, Shaozhen Hou, Jian Liang Tags: Research Paper Source Type: research

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage
AbstractObjectivesThe myoblast cell line, C2C12, has been utilised extensively in vitro as an examination model in understanding metabolic disease progression. Although it is indispensable in both preclinical and pharmaceutical research, a comprehensive review of its use in the investigation of insulin resistance progression and pharmaceutical development is not available.Key findingsC2C12 is a well ‐documented model, which can facilitate our understanding in glucose metabolism, insulin signalling mechanism, insulin resistance, oxidative stress, reactive oxygen species and glucose transporters at cellular and molecular l...
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Chun Y. Wong, Hani Al ‐Salami, Crispin R. Dass Tags: Review Source Type: research

Recent trends in targeting miRNAs for cancer therapy
AbstractObjectivesMicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the expression of numerous genes. Over the past decade, the study of miRNA biology in the context of cancer has led to the development of new diagnostic and therapeutic opportunities.Key findingsMicroRNA dysregulation is commonly associated with cancer, in part because miRNAs are actively involved in the mechanisms like genomic instabilities, aberrant transcriptional control, altered epigenetic regulation and biogenesis machinery defects. MicroRNA...
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Vandit Shah, Jigna Shah Tags: Review Source Type: research

A comprehensive review of therapeutic approaches available for the treatment of cholera
ConclusionsKnowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Francisca B. M. Sousa, Isabela R. S. G. Nol êto, Leticia S. Chaves, Gabriella Pacheco, Ana P. Oliveira, Mikhail M. V. Fonseca, Jand V. R. Medeiros Tags: Review Source Type: research