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Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects
AbstractObjectivesWithanolides are a group of modified C28 ergostane ‐type steroids with a C‐22, C‐26 δ‐lactone side chain or a C‐23, C‐26 γ‐lactone side chain. They enjoy a limited distribution in the plant kingdom and predominantly occur in several genera of Solanaceae. Of which, the genusPhysalis is an important resource for this type of natural molecules. The present review aims to comprehensively illustrate the structural characteristics and classification of withanolides, and particularly focus on the progression on phytochemical and pharmacological aspects of withanolides fromPhysalis ranging from Ja...
Source: Journal of Pharmacy and Pharmacology - December 10, 2019 Category: Drugs & Pharmacology Authors: Min Huang, Ji ‐Xiang He, Hui‐Xin Hu, Kan Zhang, Xiao‐Ning Wang, Bao‐Bing Zhao, Hong‐Xiang Lou, Dong‐Mei Ren, Tao Shen Tags: Review Source Type: research

Processing grapefruit juice with γ‐cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity
ConclusionThe encapsulation of BG and DHBG by γCD and the resulting attenuation of the inhibition of CYP3A activity by grapefruit juice may be applicable to juice processing for preventing drug‐grapefruit juice interactions. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 10, 2019 Category: Drugs & Pharmacology Authors: Keishi Yamasaki, Daisuke Iohara, Yoko Oyama, Narumi Nishizaki, Seitaro Kawazu, Koji Nishi, Daisuke Kadowaki, Kazuaki Taguchi, Masaki Otagiri, Hakaru Seo Tags: Research Paper Source Type: research

The safety and tolerability of Annona muricata leaf extract: a systematic review
ConclusionsThe overall outcome of the current review suggests thatA. muricata has a favourable safety and tolerability profile. Future studies investigating its use in people diagnosed with a range of cancers are warranted. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Wai ‐Jo Jocelin Chan, Andrew J. McLachlan, Jane R. Hanrahan, Joanna E. Harnett Tags: Review Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 1, Page i-iv, January 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Metoprolol protects against myocardial infarction by inhibiting miR ‐1 expression in rats
ConclusionsMetoprolol relieves MI injury via suppression miR ‐1, thus increasing its target protein Cx43 and improving intercellular communication. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Wei Qin, Longyin Zhang, Zhange Li, Dan Xiao, Yue Zhang, Huan Yang, Haiying Zhang, Chaoqian Xu, Yong Zhang Tags: Research Paper Source Type: research

Development of an on ‐line Raman spectral analytical method for monitoring and endpoint determination of the Cornu Caprae Hircus hydrolysis process
ConclusionsThe proposed Raman ‐based calibration models are expected to be used in GH hydrolysis process monitoring, leading to more rapid material information acquisition, deeper process understanding, more accurate endpoint determination and thus better product quality consistency. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Xu Yan, Wenlong Li, Xiaoli Zhang, Shaoyong Liu, Haibin Qu Tags: Research Paper Source Type: research

A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK ‐801 in mice
ConclusionsThese results imply that HCE ameliorates MK ‐801‐induced dysfunctions in prepulse inhibition, social interactions and cognitive function, partly by regulating the Akt and GSK‐3β signalling pathways. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Bokyung Koo, Ho Jung Bae, Nayeon Goo, Jaehoon Kim, Jihyun Kim, Mudan Cai, In Ho Jung, Kyungnam Cho, Seo Yun Jung, Suk Woo Chang, Dae Sik Jang, Jong Hoon Ryu Tags: Research Paper Source Type: research

Potential of myricetin to restore the immune balance in dextran sulfate sodium ‐induced acute murine ulcerative colitis
ConclusionsTaking together, these results suggest that myricetin exhibits significant protective effects against UC and it could be used as a potential treatment for UC. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Xinyan Qu, Qingjun Li, Yue Song, Anqi Xue, Yuhua Liu, Dongmei Qi, Hongjing Dong Tags: Research Paper Source Type: research

Numerical simulations of particle behaviour in a realistic human airway model with varying inhalation patterns
ConclusionsOur results indicated that particle deposition in a realistic human airway model was promoted by a vortex formation following the terminal ‐velocity‐like breath‐holding. Moreover, the inhalation flow pattern significantly influenced the behaviour and deposition of inhaled particles in the airways. Additionally, the effect of flow patterns on the particle deposition in each airway position was quantitatively evaluated by numerical simulations for a realistic human airway model. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Kazunori Kadota, Nana Inoue, Yoshihiro Matsunaga, Tetsushi Takemiya, Kenji Kubo, Hideki Imano, Hiromasa Uchiyama, Yuichi Tozuka Tags: Research Paper Source Type: research

Allosteric modulators restore orthosteric agonist binding to mutated CB1 receptors
ConclusionsBased on our findings, we provide evidence of a therapeutic application for allosteric modulators in situations where a mutation in the receptor may hinder its function. By utilizing allosteric modulators, restoration of orthosteric binding may be possible. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Rachel Dopart, Debra A. Kendall Tags: Research Paper Source Type: research

Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma
ConclusionsFindings of this study demonstrated significant antiproliferative and antitumorigenic properties of saffron in osteosarcoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Bilal Ege, Onder Yumrutas, Miray Ege, Mustafa Pehlivan, Ibrahim Bozgeyik Tags: Research Paper Source Type: research

Total flavones of Rhododendron simsii Planch flower protect rat hippocampal neuron from hypoxia ‐reoxygenation injury via activation of BKCa channel
ConclusionsTotal flavones ofR. simsii Planch flower had a protective effect against H/R injury in rat hippocampal neuron, and activation of BKCa channel may contribute to the neuroprotection. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Yan Guo, Xiao ‐Meng Yu, Shuo Chen, Ji‐Yue Wen, Zhi‐Wu Chen Tags: Research Paper Source Type: research

Phytochemical profile and protective effect of Ocimum basilicum aqueous extract in doxorubicin/irradiation ‐induced testicular injury
ConclusionsThe study highlights the protective role of OB aqueous extract in hampering most of the harmful chemotherapy/radiotherapy ‐induced outcomesvia its antioxidant, antiapoptotic and cell regeneration abilities. Such findings may offer an incentive in expanding its use during chemotherapy and radiotherapy. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 9, 2019 Category: Drugs & Pharmacology Authors: Rasha Y. M. Ibrahim, Suzan M. Mansour, Wafaa M. Elkady Tags: Research Paper Source Type: research