Journal of Pharmacy and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury
ConclusionsIcariin liposome has excellent therapeutic effects on acute blunt muscle injury in rats by improving immunity, repairing cytoskeleton and cellular integrity, anti ‐inflammation, anti‐fibrosis and antioxidant stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 21, 2020 Category: Drugs & Pharmacology Authors: Jinwu Wang, Gaosheng Zhu, Xingyu Wang, Jie Cai, Linzhen Xie, Wenhao Zheng, Yongzeng Feng, Qiang Guo, Hua Chen, Leyi Cai Tags: Research Paper Source Type: research

Cumulative effects of ciprofloxacin and pilocarpine on cytotoxicity and G0 phase arrest in hepatoma ‐derived Hep G2 cell line
ConclusionsCiprofloxacin imposed mitochondrial ‐independent apoptosis while PILO + CPF caused mitochondrial‐dependent and independent apoptosis simultaneously. Consequently, coadministration of PILO and CPF causes intense cytotoxic effects through targeting the mitochondria, DNA gyrase enzyme and other unknown mechanisms. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 20, 2020 Category: Drugs & Pharmacology Authors: Leila Sadeghi, Somaiyeh Maleki, Gholamreza Dehghan Tags: Research Paper Source Type: research

Kaempferol ameliorates secretagogue ‐induced pseudo‐allergic reactions via inhibiting intracellular calcium fluctuation
ConclusionsThe inhibition of the process of PLC γ phosphorylation to Ca2+ mobilization represents a major strategy in Kaempferol ‐suppressed pseudo‐allergic reactions. Thus, Kaempferol could be considered as a therapeutic drug candidate for non‐IgE‐mediated allergic reactions or inflammations. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 17, 2020 Category: Drugs & Pharmacology Authors: Jiao Cao, Yuejin Wang, Shiling Hu, Yuanyuan Ding, Qianqian Jia, Jing Zhu, Hongli An Tags: Research Paper Source Type: research

LncRNA Fendrr inhibits hypoxia/reoxygenation ‐induced cardiomyocyte apoptosis by downregulating p53 expression
ConclusionsFendrr can inhibit H/R ‐induced cardiomyocyte apoptosis, which is partly through promoting the ubiquitination and degradation of p53 by increasing the binding of Cop1 and p53. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 14, 2020 Category: Drugs & Pharmacology Authors: Xiang Li, Liangchun Ni, Weixin Wang, Liang Zong, Bi Yao Tags: Research Paper Source Type: research

Corrigendum
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page 1000-1000, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti ‐inflammatory molecule PH46A
ConclusionsThe observed profile of cytokine modulation (IL ‐6/ TNF‐α, IL‐8) and inhibition of release of NO and 5‐LOX may contribute to thein vivo effects demonstrated by indane dimers and PH46A (1) in murine models of colitis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Kit Chan, Neil Frankish, Tao Zhang, Abdulilah Ece, Aoife Cannon, Jacintha O'Sullivan, Helen Sheridan Tags: Research Paper Source Type: research

Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo
ConclusionsHuosu Yangwei oral liquid could inhibit mammalian CYPs and modulated the metabolic half ‐life of apatinib bothin vitro andin vivo. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Sheng ‐Quan Fang, Jian Huang, Feng Zhang, Hong‐Mei Ni, Qi‐Long Chen, Jun‐Ran Zhu, Zhi‐Chao Fu, Liang Zhu, Wei‐Wei Hao, Guang‐Bo Ge Tags: Research Paper Source Type: research

Pharmacological screening of fenofibrate ‐loaded solid dispersion in fructose‐induced diabetic rat
ConclusionsThis newly formulated SDF would be a promising alternative for conventional fenofibrate in treating hyperlipidaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Milon Kumar Ghosh, Mir Imam Ibne Wahed, Rafiqul Islam Khan, Anwar Habib, Ranjan Kumar Barman Tags: Research Paper Source Type: research

Encapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity
ConclusionsLayered double hydroxides are good vehicles to improve stability, resistance to degradation of CUR, also they are useful to improve solubility, provide a controlled release and improve the cytotoxic activity. Additionally, it was shown that the composition of the M+2 cation of LDH affects its properties and structure and that this directly influences its biological activity. The findings are important to select the composition of the encapsulation vehicle for a specific activity. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Filiberto Guti érrez‐Gutiérrez, Cecilia Sánchez‐Jiménez, Itzia Azucena Rangel‐Castañeda, Gregorio Guadalupe Carbajal‐Arízaga, Adriana Macaria Macías‐Lamas, Araceli Castillo‐Romero, Karina Jeanette Parra‐Saavedra Tags: Research Paper Source Type: research

Self ‐nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in‐vivo studies
ConclusionOur results suggest that SNEDDS is a promising carrier for voriconazole ocular delivery and this encourages further clinical studies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Bakoliarisoa Nivomalala Voahangy Rasoanirina, Mohamed Ali Lassoued, Karim Miladi, Zoarilala Razafindrakoto, Raja Cha âbane‐Banaoues, David Ramanitrahasimbola, Muriel Cornet, Souad Sfar Tags: Research Paper Source Type: research

Design of enamides as new selective monoamine oxidase ‐B inhibitors
ConclusionsThese results encourage further studies on the enamide scaffold as potential drug candidates for the treatment of Alzheimer's and Parkinson's diseases. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Fathima Sahla Kavully, Jong Min Oh, Sanal Dev, Swafvan Kaipakasseri, Ashique Palakkathondi, Ajeesh Vengamthodi, Rinshana Fathima Abdul Azeez, Anna Rita Tondo, Orazio Nicolotti, Hoon Kim, Bijo Mathew Tags: Research Paper Source Type: research

Development of a Gaussian Process – feature selection model to characterise (poly)dimethylsiloxane (Silastic®) membrane permeation
ConclusionsThis study highlights important considerations in the development of relevant models and in the construction and use of the data sets used in such studies, particularly that highly correlated descriptors should be removed from data sets. Predictive models are improved by the methodology adopted in this study, notably the systematic evaluation of descriptors, rather than simply using any and all available descriptors, often based empirically onin vitro experiments. Such findings also have clear relevance to a number of other fields. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Yi Sun, Mark Hewitt, Simon C. Wilkinson, Neil Davey, Roderick G. Adams, Darren R. Gullick, Gary P. Moss Tags: Research Paper Source Type: research

Pyoluteorin induces cell cycle arrest and apoptosis in human triple ‐negative breast cancer cells MDA‐MB‐231
ConclusionOur studies revealed that pyoluteorin had potent proliferation inhibition against MDA ‐MB‐231 cells through arresting cell cycle at G2/M phase and inducing caspase ‐3‐dependent apoptosis by mitochondrial pathway, implying that pyoluteorin may be a potential lead compound for drug discovery of human triple‐negative breast cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Ting Ding, Luo ‐Jie Yang, Wei‐Dong Zhang, Yun‐Heng Shen Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page i-iv, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Treatment of diabetic peripheral neuropathy: a review
The objectives of this paper are to review current guidelines for the pharmacological management of DPN and to discuss research rel evant to the further development of pharmacological recommendations for the treatment of diabetic neuropathy.SummaryDiabetic neuropathy is a highly prevalent, disabling condition, the management of which is associated with significant costs. Evidence supports the use of specific anticonvulsants and antidepressants for pain management in patients with diabetic peripheral neuropathy. All current guidelines advise a personalised approach with a low ‐dose start that is tailored to the maximum re...
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Maher R. Khdour Tags: Review Source Type: research