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Carissa carandas L. – phyto‐pharmacological review
ConclusionsThis current review offers primary data for further research work. The in ‐vitro evaluations as well as in‐vivo models/experiments have provided a biosynthetic observation for its various ethno‐pharmacological uses and even pharmacological properties. This review would provide all valuable information which will be beneficiary to conduct some important pharmacokinet ic and toxicological research works on human models with respect to ensure the effects of active ingredients in the body and even to validate its safety issues in clinical aspects. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Sonia Singh, Meenakshi Bajpai, Pradeep Mishra Tags: Review Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 12, Page i-iv, December 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Pinoresinol ‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
ConclusionsPinoresinol ‐4‐O‐β‐D‐glucopyranoside is a natural entity combating oxidative stress, hepatic damage and diabetes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Fadia S. Youssef, Mohamed L. Ashour, Hesham A. El ‐Beshbishy, Alaaeldin Ahmed Hamza, Abdel Nasser B. Singab, Michael Wink Tags: Research Paper Source Type: research

The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos
ConclusionsThis study could be a meaningful investigation to provide mechanistic insights into the hepatoprotective effect of lotus leaf and further lay a theoretical basis for the clinical application of lotus leaf. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Zhipeng Wang, Panpan Zhao, Yuanyuan Zhang, Shan Shi, Xiaohui Chen Tags: Research Paper Source Type: research

Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
ConclusionsThe study expands the understanding of the pharmacological properties of Berberine and its applicability as a radiosensitizer towards treating liver cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva Tags: Research Paper Source Type: research

Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?
ConclusionsA loading dose of up to 300  mg of micafungin is needed for the treatment of invasive candidiasis in ICU patients while a maintenance dose of up to 200 mg can be considered in empirical antifungal treatment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Iasonas Kapralos, Efstratios Mainas, Efthymios Neroutsos, Stella Apostolidi, Maria Siopi, Olympia Apostolopoulou, George Dimopoulos, Helen Sambatakou, Georgia Valsami, Joseph Meletiadis, Aristides Dokoumetzidis Tags: Research Paper Source Type: research

Catechol protects against iron ‐mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
ConclusionThese results suggest the neuroprotective effects of catechol in iron ‐mediated oxidative brain injury. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Veronica F. Salau, Ochuko L. Erukainure, Neil A. Koorbanally, Md. Shahidul Islam Tags: Research Paper Source Type: research

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu ‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases
ConclusionsCYP1A2, 2C19 and UGT1As play an important role in isobavachin metabolism. Isobavachin demonstrated broad ‐spectrum inhibition of CYPs and UGTs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Han Xing, Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ ‐induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes
ConclusionKigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Oladapo F. Fagbohun, Babatunde Olawoye, Adedeji N. Ademakinwa, Kehinde A. Jolayemi, Titus A. M. Msagati Tags: Research Paper Source Type: research

Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra ‐performance liquid chromatography coupled time‐of‐flight mass spectrometry
ConclusionsThis work revealed thein ‐vivo metabolism of FF, and reported the characteristic metabolic reactions of lignans for the first time. It was also provided the foundation for the further investigation on pharmacodynamic components of FF or TCMs containing FF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Feng ‐xiang Zhang, Zi‐ting Li, Chang Li, Min Li, Zhi‐hong Yao, Xin‐sheng Yao, Yi Dai Tags: Research Paper Source Type: research

Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin ‐O‐glucuronide in HeLa1A1 cells
ConclusionsCYP1A1 and CYP2C9, UGT1A1, UGT1A7, UGT1A8 and UGT1A9, and MRP4 all played important roles in the metabolism and disposition of bavachin. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Yang Li, Chunxia Xu, Jinjin Xu, Zifei Qin, Shishi Li, Liufang Hu, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti ‐inflammatory agent and as adjuvant in psoriasis therapy
ConclusionsThe results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: N ícolas de Castro Campos Pinto, Mariana de Souza Ferreira Maciel, Nathalia dos Santos Rezende, Ana Paula do Nascimento Duque, Renata de Freitas Mendes, Jucélia Barbosa Silva, Monique de Rezende Evangelista, Luana Cahon Monteiro, Josiane Mello S Tags: Research Paper Source Type: research

Therapeutic effects of a çaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin
ConclusionsThe therapeutic effect of ASE was similar to that of rosuvastatin in reducing dyslipidemia and hepatic steatosis but was better in reducing oxidative damage and hyperglycaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Thamires Barros Tavares, Izabelle Barcellos Santos, Graziele Freitas Bem, Dayane Teixeira Ognibene, Ana Paula Machado Rocha, Roberto Soares Moura, Angela de Castro Resende, Julio Beltrame Daleprane, Cristiane Aguiar Costa Tags: Research Paper Source Type: research

Umbelliprenin relieves paclitaxel ‐induced neuropathy
ConclusionsUmbelliprenin alleviated neuropathic pain, and decreased serum IL ‐6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Jafar Shahraki, Ramin Rezaee, Sabereh Mohammadzehi Kenar, Samaneh Setoodeh Nezhad, Gholamreza Bagheri, Hosseinali Jahantigh, Konstantinos Tsarouhas, Mahmoud Hashemzaei Tags: Research Paper Source Type: research

Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti ‐apoptotic and antioxidative activity
ConclusionsThis study emphasized the immune ‐modulatory and antioxidative effects of shikonin, which may have an important healing effect on the severity of EAE. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Mehrdad Nasrollahzadeh Sabet, Sajjad Biglari, Hamid Reza Khorram Khorshid, Emran Esmaeilzadeh Tags: Research Paper Source Type: research