Short ‐chain fatty acids oppositely altered expressions and functions of intestinal cytochrome P4503A and P‐glycoprotein and affected pharmacokinetics of verapamil following oral administration to rats

ConclusionsShort ‐chain fatty acids oppositely regulated functions and expressions of intestinal Cyp3a and P‐gp. The downregulation of P‐gp mainly contributed to the increased oral plasma verapamil exposure by SCFAs.

Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Jiaxin Zhang, Qiushi Xie, Weimin Kong, Zhongjian Wang, Shuting Wang, Kaijing Zhao, Yang Chen, Xiaodong Liu, Li Liu Tags: Research Paper Source Type: research