Impact of Chronic Sleep Disturbance for People Living With T1 Diabetes
Conclusion: Chronic sleep interruption is highly prevalent in adults with T1D and parents/carers of children with T1D with negative effects on daily functioning and well-being. Appropriate interventions are required to alleviate this burden of T1D, address modifiable risk factors for nocturnal hypoglycemia, and reduce the (perceived) need for nocturnal waking. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Barnard, K., James, J., Kerr, D., Adolfsson, P., Runion, A., Serbedzija, G. Tags: Original Articles Source Type: research

Design and Methods of a Randomized Trial of Continuous Glucose Monitoring in Persons With Type 1 Diabetes With Impaired Glycemic Control Treated With Multiple Daily Insulin Injections (GOLD Study)
Conclusions: It is expected that the results of this study will establish whether using the Dexcom G4 stand-alone system in individuals with type 1 diabetes treated with MDI improves glycemic control, reduces hypoglycemia, and influences quality-of-life indicators and glycemic variability. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Lind, M., Polonsky, W., Hirsch, I. B., Heise, T., Bolinder, J., Dahlqvist, S., Pehrsson, N.-G., Moström, P. Tags: Original Articles Source Type: research

Reducing Glucose Variability Due to Meals and Postprandial Exercise in T1DM Using Switched LPV Control: In Silico Studies
Conclusions: It is demonstrated that the announcement, or anticipation, of exercise is indispensable for letting a mono-hormonal artificial pancreas deal with the consequences of postprandial PA. In view of this the proposed controller allows switching into a conservative mode when notified of PA by the user. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Colmegna, P. H., Sanchez-Pena, R. S., Gondhalekar, R., Dassau, E., Doyle, F. J. Tags: Original Articles Source Type: research

Remote Health Consultations Supported by a Diabetes Management Web Application With a New Glucose Meter Demonstrates Improved Glycemic Control
Conclusions: OTR web application in combination with the OTV meter helped subjects with T1DM and T2DM effectively manage their diabetes and was associated with improved BG control over 12 weeks. Real-time visibility to subject data may help HCPs deliver focused and effective remote consultations. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Grady, M., Cameron, H., Levy, B. L., Katz, L. B. Tags: Original Articles Source Type: research

Machine-Learning-Based Prediction of a Missed Scheduled Clinical Appointment by Patients With Diabetes
Conclusions: Our findings may provide information to help clinicians make timely interventions to avoid MAs. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Kurasawa, H., Hayashi, K., Fujino, A., Takasugi, K., Haga, T., Waki, K., Noguchi, T., Ohe, K. Tags: Original Articles Source Type: research

White Coat Adherence in Pediatric Patients With Type 1 Diabetes Who Use Insulin Pumps
Conclusions: Diabetes care providers need to be aware that white coat adherence may occur, particularly in young children. Providers routinely download meter and insulin pump data for the 1- to 2-week period before the clinic visit. For patients exhibiting white coat adherence, their data will overestimate the patient’s actual adherence. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Driscoll, K. A., Wang, Y., Bennett Johnson, S., Lynch, R., Stephens, H., Willbur, K., Gill, E., Wright, N., Deeb, L. C. Tags: Original Articles Source Type: research

Artificial Pancreas Device Systems for the Closed-Loop Control of Type 1 Diabetes: What Systems Are in Development?
Conclusions: There are around 18 closed-loop APD systems progressing through early stages of clinical development. Only a few of these are currently in phase 3 trials and in settings that replicate real life. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Trevitt, S., Simpson, S., Wood, A. Tags: Original Articles Source Type: research

Hybrid Closed-Loop Insulin Delivery in Type 1 Diabetes During Supervised Outpatient Conditions
Conclusions: The HCL system was efficacious and safe during this study. Personally adapted HCL parameters were associated with more time in range and less time below range than default parameters. Accurate estimates of meal CHO did not contribute to improved postprandial glycemia. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Grosman, B., Ilany, J., Roy, A., Kurtz, N., Wu, D., Parikh, N., Voskanyan, G., Konvalina, N., Mylonas, C., Gottlieb, R., Kaufman, F., Cohen, O. Tags: Original Articles Source Type: research

Development of the Diabetes Technology Society Blood Glucose Monitor System Surveillance Protocol
Conclusion: This program is needed because currently once a BGMS product has been cleared for use by the FDA, no systematic postmarket Surveillance Program exists that can monitor analytical performance and detect potential problems. This protocol will allow identification of inaccurate and unreliable BGMSs currently available on the US market. The DTS Surveillance Program will provide BGMS manufacturers a benchmark to understand the postmarket analytical performance of their products. Furthermore, patients, health care professionals, payers, and regulatory agencies will be able to use the results of the study to make info...
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Klonoff, D. C., Lias, C., Beck, S., Parkes, J. L., Kovatchev, B., Vigersky, R. A., Arreaza-Rubin, G., Burk, R. D., Kowalski, A., Little, R., Nichols, J., Petersen, M., Rawlings, K., Sacks, D. B., Sampson, E., Scott, S., Seley, J. J., Slingerland, R., Vesp Tags: Original Articles Source Type: research

Development of a Microsphere-Based System to Facilitate Real-Time Insulin Monitoring
Conclusions: We have developed a microsphere-based system to rapidly measure levels of insulin and insulin analogs. We have further demonstrated proof of concept that this bead detection system can be implemented in a lab-on-a-chip format, which will be further developed and combined with microdialysis for real-time monitoring of insulin in vivo. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Kahanovitz, L., Seker, E., Marks, R. S., Yarmush, M. L., Konry, T., Russell, S. J. Tags: Original Articles Source Type: research

Feasibility of an Orthogonal Redundant Sensor incorporating Optical plus Redundant Electrochemical Glucose Sensing
Conclusions: Combining simple and orthogonal sensor redundancy via a single insertion is feasible, with accuracy comparing favorably to current generation nonredundant sensors. Addition of an optical component potentially improves sensor reliability compared to electrochemical sensing alone. Further improvement in optical sensing performance is required prior to clinical application. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: McAuley, S. A., Dang, T. T., Horsburgh, J. C., Bansal, A., Ward, G. M., Aroyan, S., Jenkins, A. J., MacIsaac, R. J., Shah, R. V., ONeal, D. N. Tags: Original Articles Source Type: research

Redundancy in Glucose Sensing: Enhanced Accuracy and Reliability of an Electrochemical Redundant Sensor for Continuous Glucose Monitoring
Conclusions: Electrochemical redundancy enhances glucose sensor accuracy and display time compared with each individual sensing element alone. ERS performance compares favorably with ‘best-in-class’ of non-redundant sensors. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Sharifi, A., Varsavsky, A., Ulloa, J., Horsburgh, J. C., McAuley, S. A., Krishnamurthy, B., Jenkins, A. J., Colman, P. G., Ward, G. M., MacIsaac, R. J., Shah, R., ONeal, D. N. Tags: Original Articles Source Type: research

Technology Use in Transition-Age Patients With Type 1 Diabetes: Reality and Promises
This article reviews the available resources, patterns of use in transition-age youth, and explores opportunities to advance technology use in transitioning patients with T1D from pediatric to adult care. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Los, E., Ulrich, J., Guttmann-Bauman, I. Tags: Guest Editors: Katharine Barnard, Kimberly Driscoll, Michael Harris, and Jill Weissberg-Benchell Source Type: research

Psychological Reactions Associated With Continuous Glucose Monitoring in Youth
Glucose monitoring is prerequisite to all other diabetes self-care behaviors and helps patients to reduce their risk for diabetes-related complications due to elevated glycemia. Because of the amount of information available and the ability to deliver glucose results in real-time, continuous glucose monitoring (CGM) has the ability to improve on self-monitoring blood glucose. However, epidemiologic data demonstrate slow uptake of CGM by patients, especially among youth. Several new diabetes therapies rely on CGM for feedback on patients’ glucose levels to optimize treatment (eg, the low-glucose suspend insulin pump) ...
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Patton, S. R., Clements, M. A. Tags: Guest Editors: Katharine Barnard, Kimberly Driscoll, Michael Harris, and Jill Weissberg-Benchell Source Type: research

Influences on Technology Use and Efficacy in Type 1 Diabetes
The majority of people with type 1 diabetes have suboptimal glycemic control, increasing their complication risk. Technology to support diabetes self-care has advanced significantly and includes self-monitoring of blood glucose (SMBG), insulin pump therapy (IPT), continuous glucose monitoring (CGM), and sensor-augmented pump therapy (SAPT), which are stepping stones toward the "artificial pancreas" using closed-loop technology. Use of these technologies improves clinical outcomes for patients with the appropriate skills and motivation. This review addresses the psychosocial factors that influence both technology provision ...
Source: Journal of Diabetes Science and Technology - May 2, 2016 Category: Endocrinology Authors: Franklin, V. Tags: Guest Editors: Katharine Barnard, Kimberly Driscoll, Michael Harris, and Jill Weissberg-Benchell Source Type: research