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IQWiG Reanalyzes and Raises Questions About an Article by Ly et al Which Concluded Low Glucose Suspend Is Very Beneficial
In 2013, Ly et al published a study in JAMA reporting a massive reduction in the frequency of severe hypoglycemic events when the patients used sensor augmented insulin pump therapy with low glucose suspense. The data of this study were reanalyzed by the IQWiG when this German institute started its evaluation of the evidence for continuous glucose monitoring (CGM) usage. The IQWiG came to a contrary conclusion than the authors of the Ly study. Decisive for this was the statistical analysis of the Ly study that led the IQWiG to evaluate this result as a lack of evidence for the superiority of CGM (plus pump) for preventing ...
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Heinemann, L., Hermanns, N. Tags: Commentary Source Type: research

How Should Blood Glucose Meter System Analytical Performance Be Assessed?
Blood glucose meter system analytical performance is assessed by comparing pairs of meter system and reference instrument blood glucose measurements measured over time and across a broad array of glucose values. Consequently, no single, complete, and ideal parameter can fully describe the difference between meter system and reference results. Instead, a number of assessment tools, both graphical (eg, regression plots, modified Bland–Altman plots, and error grid analysis) and tabular (eg, International Organization for Standardization guidelines, mean absolute difference, and mean absolute relative difference) have be...
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Simmons, D. A. Tags: Commentary Source Type: research

Diabetes Device Interoperability for Improved Diabetes Management
Scientific and technological advancements have led to the increasing availability and use of sophisticated devices for diabetes management, with corresponding improvements in public health. These devices are often capable of sharing data with a few other specific devices but are generally not broadly interoperable; they cannot work together with a wide variety of other devices. As a result of limited interoperability, benefits of modern diabetes devices and potential for development of innovative new diabetes technologies are not being fully realized. Here we discuss diabetes device interoperability in general, then focus ...
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Silk, A. D. Tags: Commentary Source Type: research

Usability of the Novel Liraglutide 3.0 mg Pen Injector Among Overweight or Obese Adult Patients With or Without Prior Injection Experience
Conclusions: The liraglutide 3.0 mg pen injector is safe and easy to use for liraglutide administration. New device features allow for safe use after brief training. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Fujioka, K., Sparre, T., Sun, L. Y.-H., Krogsgaard, S., Kushner, R. F. Tags: Obesity Technology Source Type: research

Clinical Use and Evaluation of Insulin Pens
Insulin pens are more accurate and easier to teach than other methods of insulin delivery. They also do not suffer from the risk of mismatch of insulin concentration and type of insulin syringe. The ISO standard used to test insulin pens, however, needs to be updated to reflect their clinical use. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Ginsberg, B. H. Tags: Technology Reports Source Type: research

Dosing Accuracy of Two Disposable Insulin Pens According to New ISO 11608-1: 2012 Requirements
Conclusion: Both insulin pens fulfilled the dosing accuracy requirements defined by ISO 11608-1:2012 at all 3 dosage levels. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Abdel-Tawab, M., Schmitz, M., Kamlot, S., Schubert-Zsilavecz, M. Tags: Technology Reports Source Type: research

Fundus Autofluorescence Captured With a Nonmydriatic Retinal Camera in Vegetarians Versus Nonvegetarians
Conclusions: Our preliminary results show that in this cohort, vegetarians had statistically significant lower levels of autofluorescence. These findings can have potential implications regarding long-term retinal health and risk for developing certain diseases over decades in subjects at risk for vision-threatening diseases. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Kommana, S. S., Padgaonkar, P., Mendez, N., Wu, L., Szirth, B., Khouri, A. S. Tags: Original Articles Source Type: research

Perioperative Hyperglycemia and Glucose Variability in Gynecologic Laparotomies
Conclusions: Hyperglycemia and glucose variability seem to be a minor problem during gynecologic laparotomy. Based on the current data, we would not advocate standardized glucose measurements in every patient without diabetes undergoing gynecologic laparotomy. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Polderman, J. A. W., Hollmann, M. W., DeVries, J. H., Preckel, B., Hermanides, J. Tags: Original Articles Source Type: research

Comparison of Subcutaneous Regular Insulin and Lispro Insulin in Diabetics Receiving Continuous Nutrition: A Numerical Study
Conclusions: Subcutaneous regular insulin may be the short-acting insulin preparation of choice for this subset of diabetic patients. Clinical trial is required before a definitive recommendation can be made. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Stull, M. C., Strilka, R. J., Clemens, M. S., Armen, S. B. Tags: Original Articles Source Type: research

Decreased eGFR as a Risk Factor for Heart Failure in 13 781 Individuals With Type 1 Diabetes
Conclusions: In individuals with T1D, risk of hospitalization for heart failure was over 2 times greater at eGFR 45-60 ml/min/1.73 m2 and more than 3 times greater at eGFR <30 ml/min/1.73 m2 when compared to normal eGFR. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Vestberg, D., Rosengren, A., Olsson, M., Gudbjörnsdottir, S., Haraldsson, B., Svensson, A.-M., Lind, M. Tags: Original Articles Source Type: research

Accuracy and Injection Force of the Gla-300 Injection Device Compared With Other Commercialized Disposable Insulin Pens
Conclusion: All tested pens were accurate according to ISO criteria, and the Gla-300 SoloSTAR pen displayed the greatest reproducibility and lowest injection force of any of the 3 tested devices. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Klonoff, D., Nayberg, I., Thonius, M., See, F., Abdel-Tawab, M., Erbstein, F., Haak, T. Tags: Original Articles Source Type: research

Parsimonious Description of Glucose Variability in Type 2 Diabetes by Sparse Principal Component Analysis
Conclusions: Starting from a pool of 25 indices assessed from CGM time series in T2D subjects, reduced subsets of metrics virtually providing the same information content can be determined by SPCA. The fact that these indices also appear in the parsimonious description of GV in T1D may indicate that they could be particularly informative of GV in diabetes, regardless of the specific type of disease. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Fabris, C., Facchinetti, A., Fico, G., Sambo, F., Arredondo, M. T., Cobelli, C., on behalf of the MOSAIC EU Project Consortium Tags: Original Articles Source Type: research

A C-Peptide-Based Model of Pancreatic Insulin Secretion in Extremely Preterm Neonates in Intensive Care
Conclusions: A sex-based insulin secretion model was created and incorporated into a model-based glycemic control framework. Nutritional intake did not predict insulin secretion, indicating that insulin secretion is a complex function of a number of metabolic factors. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Dickson, J. L., Alsweiler, J., Gunn, C. A., Pretty, C. G., Chase, J. G. Tags: Original Articles Source Type: research

Sensitivity of the Predictive Hypoglycemia Minimizer System to the Algorithm Aggressiveness Factor
Conclusion: The Hypo Minimizer’s controller took preemptive action to prevent hypoglycemia based on predicted changes in CGM glucose levels. The most aggressive setting was quickest to take action to reduce insulin delivery below basal and achieved the best glucose metrics. (Source: Journal of Diabetes Science and Technology)
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Finan, D. A., Dassau, E., Breton, M. D., Patek, S. D., McCann, T. W., Kovatchev, B. P., Doyle, F. J., Levy, B. L., Venugopalan, R. Tags: Original Articles Source Type: research

Advances in Patient Self-Monitoring of Blood Glucose
In 2 articles of the present issue, Bendini et al report about performance results obtained with 2 blood glucose monitoring systems of the Contour Next platform. Using several analysis methods, the authors demonstrate a very high accuracy, which meets all actual regulatory performance criteria. With consistent MARD results < 5% under daily routine conditions, this meter platform is finally fulfilling the accuracy request as set forth by the American Diabetes Association already in the late 1980s. This meter platform is representative for the successful effort of the device manufacturers who were consequently improving t...
Source: Journal of Diabetes Science and Technology - December 30, 2015 Category: Endocrinology Authors: Pfützner, A. Tags: Original Articles Source Type: research