Journal of Clinical Pharmacy and Therapeutics 
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Journal of Clinical Pharmacy and Therapeutics, Ahead of Print. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 18, 2017 Category: Drugs & Pharmacology Source Type: research
Population pharmacokinetics of levetiracetam in neonates with seizures
ConclusionBased on the PK of LEV in neonates and the influence of the final PK model, a priori dosing guidelines are proposed considering CRCL, BW and LEV plasma concentrations between 6 and 20 mg/L for NS treatment.
Visual predictive check for Levetiracetam plasma concentrations vs time after last dose profiles in neonates with seizures and dosing recommendations based on simulations from final pharmacokinetic model to maintain goal Levetiracetam plasma concentrations (6 – 20 mg/L) with q8hr, q12h, or q24h regimens. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 18, 2017 Category: Drugs & Pharmacology Authors: V. Lima ‐Rogel, E. J. López‐López, S. E. Medellín‐Garibay, L. M. Gómez‐Ruiz, C. Romero‐Méndez, R. C. Milán‐Segovia, S. Romano‐Moreno Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetics of dexmedetomidine administered to patients with end ‐stage renal failure and secondary hyperparathyroidism undergoing general anaesthesia
Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 3, Page 414-421, June 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 16, 2017 Category: Drugs & Pharmacology Authors: W.
Zhong
MD
,
Y.
Zhang
PhD
,
M. ‐Z.
Zhang
PhD
,
X.‐H.
Huang
PhD
,
Y.
Li
MD
,
R.
Li
MD
,
Q.‐W.
Liu
PhD Source Type: research
Pharmacokinetics of dexmedetomidine administered to patients with end ‐stage renal failure and secondary hyperparathyroidism undergoing general anaesthesia
Journal of Clinical Pharmacy and Therapeutics, EarlyView. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 16, 2017 Category: Drugs & Pharmacology Source Type: research
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Journal of Clinical Pharmacy and Therapeutics, Ahead of Print. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 16, 2017 Category: Drugs & Pharmacology Source Type: research
Effect of ribonucleotide reductase M1 expression on overall survival in patients with pancreatic cancer receiving gemcitabine chemotherapy: A literature ‐based meta‐analysis
Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 2, Page 163-169, April 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 6, 2017 Category: Drugs & Pharmacology Source Type: research
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Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 2, Page 163-169, April 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 6, 2017 Category: Drugs & Pharmacology Source Type: research
Community pharmacists —Leaders for antibiotic stewardship in respiratory tract infection
Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 2, Page 302-307, April 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 4, 2017 Category: Drugs & Pharmacology Source Type: research
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Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 2, Page 302-307, April 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 4, 2017 Category: Drugs & Pharmacology Source Type: research
Association of CYP2C9*3 with phenytoin ‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta‐analysis
Summary
What is known and objectiveStevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions that can be induced by phenytoin (PHT). CYP2C9*3 is the key enzyme in PHT metabolism. The aim of this meta‐analysis was to evaluate the association between CYP2C9*3 and PHT‐induced SJS/TEN.
MethodsAn extensive search was performed in multiple databases, including the Cochrane Library, EMBASE, PubMed, OVID and EBSCO. Studies exploring the relationship between CYP2C9*3 and PHT‐induced SJS and TEN were included. Odds ratios (ORs) with corresponding 95% confidence intervals (CI) ...
Source: Journal of Clinical Pharmacy and Therapeutics - December 1, 2017 Category: Drugs & Pharmacology Authors: X. Wu, W. Liu, W. Zhou Tags: ORIGINAL ARTICLE Source Type: research
Marked efficacy of combined three ‐drug therapy (Sodium Valproate, Topiramate and Stiripentol) in a patient with Dravet syndrome
We present a case of DS, in which treatment with CLB could not be continued because of the appearance of adverse reactions to it. Replacement with topiramate (TPM) proved to be markedly effective.
What is new and conclusionIt is suggested that combination therapy with VPA, TPM and STP is for DS epilepsy.
In drug therapy for patients with Deavet syndrome, combination therapy of Valproate, Clobazam and Stiripentol is recommended. In this case, combination therapy using Topiramate instead of Clobazam, it was effective for epileptic seizures. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - December 1, 2017 Category: Drugs & Pharmacology Authors: M. Morimoto, S. Shimakawa, T. Hashimoto, T. Kitaoka, S. Kyotani Tags: CASE REPORT Source Type: research
Pharmacokinetics of dexmedetomidine administered to patients with end ‐stage renal failure and secondary hyperparathyroidism undergoing general anaesthesia
Summary
What is known and ObjectiveThe primary objective of this study was to compare the pharmacokinetics of dexmedetomidine in patients with end‐stage renal failure and secondary hyperparathyroidism with those in normal individuals.
MethodFifteen patients with end‐stage renal failure and secondary hyperparathyroidism (Renal‐failure Group) and 8 patients with normal renal and parathyroid gland function (Control Group) received intravenous 0.6 μg/kg dexmedetomidine for 10 minutes before anaesthesia induction. Arterial blood samples for plasma dexmedetomidine concentration analysis were drawn at regular intervals a...
Source: Journal of Clinical Pharmacy and Therapeutics - December 1, 2017 Category: Drugs & Pharmacology Authors: W. Zhong, Y. Zhang, M. ‐Z. Zhang, X.‐H. Huang, Y. Li, R. Li, Q.‐W. Liu Tags: ORIGINAL ARTICLE Source Type: research
Effect of ribonucleotide reductase M1 expression on overall survival in patients with pancreatic cancer receiving gemcitabine chemotherapy: A literature ‐based meta‐analysis
In conclusion, the expression of RRM1 can be considered a predictor of poor survival in patients with pancreatic cancer receiving gemcitabine chemotherapy. RRM1 expression assessment could provide more detailed information for patients with pancreatic cancer and could be used to optimize therapeutic schemes.
The expression of RRM1 can be considered a predictor of poor survival in patients with pancreatic cancer receiving gemcitabine chemotherapy. RRM1 expression assessment could provide more detailed information for patients with pancreatic cancer and could be used to optimize therapeutic schemes. (Source: Journal of Clin...
Source: Journal of Clinical Pharmacy and Therapeutics - December 1, 2017 Category: Drugs & Pharmacology Authors: Q. L. Han, Y. H. Zhou, Y. Lyu, H. Yan, G. H. Dai Tags: REVIEW ARTICLE Source Type: research
Community pharmacists —Leaders for antibiotic stewardship in respiratory tract infection
Summary
What is known and objectiveHospital‐based pharmacists are established antibiotic stewards, but the potential for community pharmacists is largely untapped. This commentary explores the potential leadership role of the community pharmacist in antibiotic stewardship using upper respiratory tract infection (URTI) as an example.
CommentCommunity pharmacists are well placed for antibiotic stewardship, possessing the capability (knowledge of medicines), opportunity (contact with prescribers and patients) and inherent commitment. Providing further motivation with information on patient education has great potential to c...
Source: Journal of Clinical Pharmacy and Therapeutics - December 1, 2017 Category: Drugs & Pharmacology Authors: S. Essack, J. Bell, A. Shephard Tags: COMMENTARY Source Type: research
