Journal of Clinical Pharmacy and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nature's first “atypical opioids”: Kratom and mitragynines
Summary What is known and objectiveAdvances in pain research have led to an understanding that many pains are driven by more than one underlying (patho)physiologic cause (ie, they are “multimechanistic”) and that better pain relief is obtained with fewer adverse effects when an analgesic is correspondingly multimechanistic. At least two of the more‐modern analgesics combine opioid and non‐opioid mechanisms, and have become known as “atypical opioids.” Less well known is that just as Nature evolved opioids, it also evolved atypical opioids, presaging modern drug discovery efforts. CommentTraditional (typical) op...
Source: Journal of Clinical Pharmacy and Therapeutics - March 9, 2018 Category: Drugs & Pharmacology Authors: R. B. Raffa, J. V. Pergolizzi, R. Taylor, M. H. Ossipov, Tags: COMMENTARY Source Type: research

Nature's first “atypical opioids”: Kratom and mitragynines
Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 3, Page 437-441, June 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 8, 2018 Category: Drugs & Pharmacology Authors: R. B. Raffa PhD , J. V. Pergolizzi Jr, MD , R. Taylor Jr, PhD , M. H. Ossipov PhD , Source Type: research

Nature's first “atypical opioids”: Kratom and mitragynines
Journal of Clinical Pharmacy and Therapeutics, EarlyView. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 8, 2018 Category: Drugs & Pharmacology Source Type: research

---
Journal of Clinical Pharmacy and Therapeutics, Ahead of Print. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 8, 2018 Category: Drugs & Pharmacology Source Type: research

Genotype and allele frequencies of TYMS rs2790 A   >  G polymorphism in a Chinese paediatric population with acute lymphoblastic leukaemia
Summary What is known and objectiveThymidylate synthase (TYMS) is an important target for methotrexate (MTX). Genetic variations in the TYMS gene contribute to the differences in treatment responses to MTX. The aim of this study was to investigate the distribution of a microRNA (miRNA) binding site polymorphism (rs2790 A > G) in the 3′‐untranslated region (3′‐UTR) of TYMS and its association with MTX concentration and haematological toxicity in Chinese paediatric patients with acute lymphoblastic leukaemia (ALL). MethodsThe Sequenom MassARRAY system was used for TYMS rs2790 A > G genotyping in 118 childre...
Source: Journal of Clinical Pharmacy and Therapeutics - March 3, 2018 Category: Drugs & Pharmacology Authors: S. ‐M. Wang, W.‐X. Zeng, W.‐S. Wu, L.‐L. Sun, D. Yan Tags: ORIGINAL ARTICLE Source Type: research

Stability of dobutamine in continuous ambulatory delivery devices
Summary What is known and objectiveContinuous infusion of dobutamine plays an important role in the management of patients with end‐stage heart failure. Home infusion of dobutamine using a continuous ambulatory delivery device (CADD) facilitates the management of patients in their home, avoiding complications associated with long‐term hospitalization. However, the stability of dobutamine in CADD is currently unknown. Therefore, this study investigated the physicochemical stability of dobutamine in CADDs at three different temperatures over various time points. MethodsSix CADDs (three containing dobutamine 10 mg/mL in ...
Source: Journal of Clinical Pharmacy and Therapeutics - March 3, 2018 Category: Drugs & Pharmacology Authors: F. Al Madfai, B. Valah, S. T. R. Zaidi, T. Wanandy, L. C. Ming, G. M. Peterson, R. P. Patel Tags: ORIGINAL ARTICLE Source Type: research

Genotype and allele frequencies of TYMS rs2790 A > G polymorphism in a Chinese paediatric population with acute lymphoblastic leukaemia
Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 4, Page 507-512, August 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 3, 2018 Category: Drugs & Pharmacology Authors: S. ‐M. Wang PhD , W.‐X. Zeng MS , W.‐S. Wu MS , L.‐L. Sun BS , D. Yan PhD Source Type: research

Genotype and allele frequencies of TYMS rs2790 A   >  G polymorphism in a Chinese paediatric population with acute lymphoblastic leukaemia
Journal of Clinical Pharmacy and Therapeutics, EarlyView. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 3, 2018 Category: Drugs & Pharmacology Authors: S. ‐M. Wang PhD , W.‐X. Zeng MS , W.‐S. Wu MS , L.‐L. Sun BS , D. Yan PhD Source Type: research

---
Journal of Clinical Pharmacy and Therapeutics, Ahead of Print. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 3, 2018 Category: Drugs & Pharmacology Source Type: research

Stability of dobutamine in continuous ambulatory delivery devices
Journal of Clinical Pharmacy and Therapeutics, EarlyView. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 2, 2018 Category: Drugs & Pharmacology Authors: F.Al Madfai BPharm, MPharmSc , B.Valah BPharm, MPharmSc , S. T. R.Zaidi BPharm, MPharm, PhD , T.Wanandy BPharm, MSc , L. C.Ming BPharm, MPharm, PhD , G. M.Peterson BPharm(Hons), PhD , R. P.Patel BPharm, MPharmSc, PhD Source Type: research

Issue information
Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 2, Page i-iv, April 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 2, 2018 Category: Drugs & Pharmacology Source Type: research

---
Journal of Clinical Pharmacy and Therapeutics, Ahead of Print. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 2, 2018 Category: Drugs & Pharmacology Source Type: research

---
Journal of Clinical Pharmacy and Therapeutics,Volume 43, Issue 2, Page i-iv, April 2018. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - March 2, 2018 Category: Drugs & Pharmacology Source Type: research