Population pharmacokinetics of levetiracetam in neonates with seizures

ConclusionBased on the PK of LEV in neonates and the influence of the final PK model, a priori dosing guidelines are proposed considering CRCL, BW and LEV plasma concentrations between 6 and 20 mg/L for NS treatment. Visual predictive check for Levetiracetam plasma concentrations vs time after last dose profiles in neonates with seizures and dosing recommendations based on simulations from final pharmacokinetic model to maintain goal Levetiracetam plasma concentrations (6 – 20 mg/L) with q8hr, q12h, or q24h regimens.
Source: Journal of Clinical Pharmacy and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research