Acquired factor XI deficiency and therapeutic plasma exchange
We report a case of acquired FXI deficiency in a pregnant woman with lupus. We proved that the inhibitor was an IgG, therefore potentially capable of crossing the placenta. While immune suppression eliminated detectable circulating inhibitor, the woman's FXI remained quite low. A multi‐disciplinary team was formed and therapeutic plasma exchange with 100% plasma replacement was performed when the patient went into labor, to acutely raise her FXI level and remove any potential non‐neutralizing inhibitor. The mother had a controllable level of bleeding during post‐TPE cesarean section; the baby had no bleeding and the ...
Source: Journal of Clinical Apheresis - October 13, 2017 Category: Hematology Authors: Geoffrey D. Wool, Angela Treml, Jonathan L. Miller Tags: CASE REPORT Source Type: research
Current strategies for the management of autologous peripheral blood stem cell mobilization failures in patients with multiple myeloma
Journal of Clinical Apheresis, EarlyView. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 5, 2017 Category: Hematology Source Type: research
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Journal of Clinical Apheresis, Ahead of Print. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 5, 2017 Category: Hematology Source Type: research
Treatment of acquired Thrombotic Thrombocytopenic Purpura in the U.S. remains heterogeneous: Current and future points of clinical equipoise
ConclusionTreatment of acquired TTP in the U.S. remains heterogeneous. Points of clinical equipoise identified were PV exchanged (1.0 vs >1.0), tapering of TPE versus none, and rituximab use. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Marshall A. Mazepa, Jay S. Raval, Mark E. Brecher, Yara A. Park Tags: RESEARCH ARTICLE Source Type: research
Epidemiology of therapeutic apheresis with a multidisciplinary approach at a high volume pediatric center
ConclusionAt a large volume pediatric hospital, TA is commonly used and can be performed safely in a variety of settings by a multidisciplinary team. This demographic review catalogs the number and type of procedures performed as a second‐line therapy or on the basis of limited evidence. Additional collaborative investigation is needed to evaluate unique implications of TA in pediatrics to maximize efficacy while preserving safety. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Rachel M. Sirignano, Matthew L. Paden, Ross Fasano, Erin K. Meyer Tags: RESEARCH ARTICLE Source Type: research
Neutropenic fever during peripheral blood progenitor cell mobilization is associated with decreased CD34+ cell collection and increased apheresis collection days
ConclusionNF during etoposide priming is associated with lower likelihood of proceeding to transplant, lower CD34+ cell dose collection, more apheresis days required for collection and a higher 30‐day readmission rate following transplant discharge. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Jack Khouri, Lisa Rybicki, Navneet Majhail, Matt Kalaycio, Edward Copelan, Brad Pohlman, Brian Hill, Robert Dean, Aleksandr Lazaryan, Betty Hamilton, Steven Andresen, Ronald Sobecks, Brian Bolwell, Hien Liu Tags: RESEARCH ARTICLE Source Type: research
Automated red blood cell exchange in preparation for filgrastim mobilization of autologous peripheral blood hematopoietic progenitor cells in a patient with sickle cell anemia
We report the use of automated red cell exchange in preparation for filgrastim mobilization in a patient with homozygous SCA. Red cell exchange was repeated just prior to high‐dose chemotherapy to mitigate the need for red cell transfusion during bone marrow reconstitution. The patient experienced no vaso‐occlusive phenomena throughout the entire episode of care and did not become iron overloaded. This approach should be considered for all patients with homozygous or compound heterozygous sickle cell disease who are candidates for auto‐HPC rescue therapy. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Yong Zhao, Jeffrey A. Bailey, Jeanne Linden, Patricia St. Pierre, Jan Cerny, Michelle Vauthrin, Mindy Greene, Robert Weinstein Tags: CASE REPORT Source Type: research
Circulating progenitor cells in patients with familial hypercholesterolemia
ConclusionsFH patients had higher CPC counts at baseline compared to age‐matched HLP and healthy controls, suggesting activation of reparative mechanism in this high risk population. Larger studies are needed to better characterize differences in CPC counts between FH subjects and HLP patients over time. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: P. B. Sandesara, V. Ramjee, N. Ghasemzadeh, Y. Guo, N. Bhatia, Q. Li, L. Vaughn, C. Nell ‐Dybdahl, E. K. Waller, E. A. Mahar, K. Brigham, P. W. F. Wilson, A. Quyyumi, N.‐A. Le, L. S. Sperling Tags: BRIEF REPORT Source Type: research
Peptide GAM immunoadsorption therapy in primary membranous nephropathy (PRISM): Phase II trial investigating the safety and feasibility of peptide GAM immunoadsorption in anti ‐PLA2R positive primary membranous nephropathy
DiscussionWith proven efficacy in removing IgG antibodies and its use as a relatively safe treatment option in a multitude of conditions, immunoadsorption has the potential to offer patients with primary MN a more directed therapy free from the short and long‐term side‐effects generally seen in this condition. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Patrick Hamilton, Durga Kanigicherla, Prasanna Hanumapura, Lars Walz, Dieter Kramer, Moritz Fischer, Paul Brenchley, Sandip Mitra Tags: RESEARCH ARTICLE Source Type: research
Therapeutic plasma exchange causing (not curing) hemolysis
(Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Brendan C. Graham, Edwin A. Burgstaler, Jeffrey L. Winters Tags: APHERESIS ILLUSTRATED Source Type: research
The management of anticoagulation in patients undergoing therapeutic plasma exchange: A concise review
We present the results of their practices and a review of the pertinent literature. As plasma is removed during TPE, replacement with all or partial non‐plasma‐containing fluids (eg, 5% albumin) may lead to significant changes in hemostasis. These changes are amplified in patients who are receiving anticoagulation. We discuss various anticoagulants as well as the monitoring and adjustment of anticoagulation before, during, and after TPE. No single guideline can be applied, but rather, patients must be monitored individually, taking into account their often complex clinical conditions and medication profiles. (Source: J...
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Sara M. Shunkwiler, Huy P. Pham, Geoffrey Wool, Tina S. Ipe, Deanna C. Fang, Elizabeth Biller, Angela Treml, John Weiss, Beverly W. Baron, Mary Berg, Tags: CONCISE REVIEWS Source Type: research
Improvement of refractory pruritus after lipoprotein ‐apheresis in arthrogryposis‐renal failure‐cholestasis syndrome
We report of significant decrease in tBA levels and drastic improvement of pruritus in a 5‐year‐old girl with arthrogryposis‐renal failure‐cholestasis syndrome. We present LA as a suitable rescue treatment option in therapy‐refractory cholestasis‐associated pruritus, at least as bridge until a long‐term solution such as entero‐biliary anastomosis or transplantation is possible. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: A. Rosales, M. Mu ñoz, A. Madrid, S. Chocron, J. M. Hernández, G. Ariceta Tags: BRIEF REPORT Source Type: research
Regional citrate anticoagulation with calcium replacement in pediatric apheresis
ConclusionRunning IV calcium at 1.4 times the inlet flow rate resulted in a lower incidence of hypocalcemia than reported in literature describing other approaches to apheresis. It nearly eliminated episodes of symptomatic hypocalcemia. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Katie Sigler, Ji Lee, Poyyapakkam Srivaths Tags: RESEARCH ARTICLE Source Type: research
Current strategies for the management of autologous peripheral blood stem cell mobilization failures in patients with multiple myeloma
This article aims at discussing the risk factors for mobilization failure in the era of novel antimyeloma drugs, defining the poor mobilizer concept and summarizing the current and future strategies for the prevention and management of mobilization failures in MM. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - October 1, 2017 Category: Hematology Authors: Ugur Sahin, Taner Demirer Tags: CONCISE REVIEWS Source Type: research
Paired comparison of therapeutic plasma exchange using the Fenwal Amicus versus TerumoBCT Spectra Optia
ConclusionsStatistical differences were seen but none were of a magnitude to be clinically relevant, indicating comparable TPE performance. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - September 23, 2017 Category: Hematology Authors: Edwin A. Burgstaler, Sandra C. Bryant, Jeffrey L. Winters Tags: RESEARCH ARTICLE Source Type: research
