Journal of Bioactive and Compatible Polymers This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Amphiphilic polysaccharide nanocarriers with antioxidant properties
The development of self-assembled nanocarriers for the encapsulation of hydrophobic antioxidants is of growing interest. Self-assembled amphiphilic chitosan conjugate nanocarriers that stabilize antioxidants were prepared based on the concept that both the nanocarrier and the antioxidant bear similar hydrophobic moieties able to establish hydrophobic interactions. This work describes the preparation and characterization of a system consisting of a palmitoyl chitosan conjugate and retinyl palmitate. Palmitic acid was coupled to chitosan using a carbodiimide-mediated coupling reaction, and two different palmitoyl chitosan co...
Source: Journal of Bioactive and Compatible Polymers - October 31, 2014 Category: Research Authors: Bossio, O., Gomez-Mascaraque, L. G., Fernandez-Gutierrez, M., Vazquez-Lasa, B., Roman, J. S. Tags: Original Articles Source Type: research

Monocyte chemoattractant protein-1 released from polycaprolactone/chitosan hybrid membrane to promote angiogenesis in vivo
We have fabricated a hybrid membrane composed of polycaprolactone and a natural polysaccharide, chitosan. The incorporation of chitosan enabled heparinization of the material via electrostatic interaction between heparin and chitosan. More importantly, since multiple cytokines have exhibited binding affinity towards heparin, heparinization of the polycaprolactone/chitosan compound also facilitated immobilization of monocyte chemoattractant protein-1, which is a well-reported pro-angiogenic chemokine. Results demonstrated that the heparinized polycaprolactone/chitosan membrane with monocyte chemoattractant protein-1 immobil...
Source: Journal of Bioactive and Compatible Polymers - October 31, 2014 Category: Research Authors: Zhang, J., Li, G., Gao, S., Yao, Y., Pang, L., Li, Y., Wang, W., Zhao, Q., Kong, D., Li, C. Tags: Original Articles Source Type: research

Bonding behavior of hydrophobically modified gelatin films on the intestinal surface
The bonding behavior was determined for hydrophobically modified alkaline-treated gelatin on wet porcine intestinal surfaces. The modified gelatin films were obtained by reacting the amino groups of alkaline-treated gelatin with fatty acid chlorides of different alkyl chain lengths, namely, hexanoyl (Hx: C6) chloride, decanoyl (Dec: C10) chloride, and stearoyl (Ste: C18) chloride. Three kinds of the films were prepared, 32HxAlGltn, 24DecAlGltn, and 26SteAlGltn that had substitution ratios of hydrophobic groups to the amino groups of 32HxAlGltn, 24DecAlGltn, and 26SteAlGltn of 32%, 24%, and 26%, respectively. The 32HxAlGltn...
Source: Journal of Bioactive and Compatible Polymers - October 31, 2014 Category: Research Authors: Yoshizawa, K., Taguchi, T. Tags: Original Articles Source Type: research

Poly(2-ethyl-(2-pyrrolidone) methacrylate) and hyaluronic acid-based hydrogels for the engineering of a cartilage-like tissue using bovine articular chondrocytes
Poly(2-ethyl-(2-pyrrolidone)methacrylate)–hyaluronic acid hydrogels based on the free radical polymerization of 2-ethyl-(2-pyrrolidone)methacrylate combined with hyaluronic acid, using N,N'-methylenebisacrylamide or triethylene glycol dimethacrylate, as cross-linking agents, were considered for tissue engineering applications. Bovine articular chondrocytes were seeded onto the poly(2-ethyl-(2-pyrrolidone)methacrylate)–hyaluronic acid hydrogels, under orbital agitation, for a total of 40 days. The engineered cell-constructs were characterized according to cell proliferation, morphology and distribution as well a...
Source: Journal of Bioactive and Compatible Polymers - October 31, 2014 Category: Research Authors: Magalhaes, J., Crawford, A., Hatton, P. V., Blanco, F. J., Roman, J. S. Tags: Original Articles Source Type: research

Neuronal differentiation of human placenta-derived multi-potent stem cells enhanced by cell body oscillation on gelatin hydrogel
In this study, the neuronal differentiation of human placenta–derived multi-potent (stem) cells was systematically optimized through the engineering of the gelatin hydrogel properties. The swelling ratio of Type A or Type B gelatin hydrogel changes during hydrogel formation in the gelatin concentration ranges from 16 to 6 wt%. In general, placenta-derived multi-potent (stem) cells effectively adhere on both, acidic and basic gelatin hydrogels with different swelling ratios as shown by the high attachment ratio of around 80%. Interestingly, adhered placenta-derived multi-potent (stem) cells had significant cell body o...
Source: Journal of Bioactive and Compatible Polymers - October 31, 2014 Category: Research Authors: Li, C., Liu, I. K.-K., Tsao, C., Chan, V. Tags: Original Articles Source Type: research

Crack prevention of biodegradable polymer coating on metal facilitated by a nano-coupled interlayer
Crack prevention of biodegradable polymer coatings on drug-eluting stents was investigated by introducing a nano-coupled layer at the interface between the metal surface and the polymer coating layer using surface-initiated ring-opening polymerization of -caprolactone. Poly(d,l-lactide-co-glycolide) coating on cobalt-chromium control and ricinoleic acid-poly(caprolactone)–grafted cobalt-chromium was carried out using electrospraying. The cracking of the biodegradable polymer coating on drug-eluting stents during ballooning was addressed by introducing a nano-coupled interlayer on the cobalt-chromium surface. The rici...
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Cho, Y., Vu, B. Q., Bedair, T. M., Park, B. J., Joung, Y. K., Han, D. K. Tags: Original Articles Source Type: research

A comparative mechanical and biocompatibility study of poly({varepsilon}-caprolactone), hybrid poly({varepsilon}-caprolactone)-silk, and silk nanofibers by colloidal electrospinning technique for tissue engineering
In this study, these problems were addressed by the modification of poly(-caprolactone) nanofibers with nanoparticles made from natural polymers, such as silk fibroin. Silk fibroin nanoparticles were prepared by desolvation and blended with poly(-caprolactone) to form a colloidal solution capable of forming nanofibers by electrospinning. Fabricated silk fibroin nanoparticles and three different nanofibers were characterized by transmission electron microscopy, variable pressure field emission scanning electron microscope, contact angle, Fourier transform infrared spectroscopy, thermogravimetric analysis, as well as an eval...
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Sheikh, F. A., Ju, H. W., Moon, B. M., Park, H. J., Kim, J.-H., Kim, S. H., Lee, O. J., Park, C. H. Tags: Original Articles Source Type: research

Electrospun poly(butylene carbonate) membranes for guided bone regeneration: In vitro and in vivo studies
A nonwoven membrane for guided bone regeneration, constituting of poly(butylene carbonate), with a backbone that is similar to poly(-caprolactone), was prepared by electrospinning. The as-fabricated poly(butylene carbonate) membranes were to be used as guided bone regeneration membranes with efficacies equal to or better than poly(-caprolactone) membranes. The contact angles of electrospun poly(butylene carbonate) membranes (fPBC) (101.90 ± 4.19°) were lower than those for electrospun poly(-caprolactone) membranes (fPCL) (117.79 ± 3.38°) (p < 0.01). To examine the biocompatibility, we investigated ...
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Xia, Y., Yao, J., Li, N., Shao, C.-H., Shen, X.-Y., Xie, L.-Z., Chen, G., Zhang, F.-M., Gu, N. Tags: Original Articles Source Type: research

Glycosaminoglycans and their sulfate derivatives differentially regulate the viability and gene expression of osteocyte-like cell lines
In conclusion, highly sulfated glycosaminoglycans inhibit osteocyte apoptosis in vitro and promote an osteoblast-supporting gene expression profile. (Source: Journal of Bioactive and Compatible Polymers)
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Tsourdi, E., Salbach-Hirsch, J., Rauner, M., Rachner, T. D., Moller, S., Schnabelrauch, M., Scharnweber, D., Hofbauer, L. C. Tags: Original Articles Source Type: research

Reducible cationic PAA-g-PEI polymeric micelle/DNA complexes for enhanced gene delivery
In this study, novel reduction-sensitive amphiphilic poly[phenethylamido-N,N-bis(acryloyl) cystine]-g-polyethylenimine (PAA-g-PEI) copolymers were synthesized by grafting low-MW PEIs onto reducible poly[phenethylamido-N,N-bis(acryloyl) cystine] (PAA). These copolymers self-assembled in aqueous solution into micelles with sizes <70 nm, as determined by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The PAA-g-PEI2000 micelles effectively condense with the plasmid DNA to form complex nanoparticles with diameters of ~100 nm at an N/P ratio of 4/1. The PAA-g-PEI2000 micelle/DNA complexes protected...
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Yuan, T., Wang, Y., Cao, W., Sun, Y., Liang, J., Fan, Y., Zhang, X. Tags: Original Articles Source Type: research

Biodegradable uniform microspheres based on solid-in-oil-in-water emulsion for drug delivery: A comparison of homogenization and fluidic device
Based on solid-in-oil-in-water emulsification, we fabricated biodegradable poly(-caprolactone) microspheres containing gentamicin using conventional homogenization and a fluidic device. The feasibility of the poly(-caprolactone) microspheres as drug carriers was evaluated in terms of encapsulation efficiency, release behavior of gentamicin, and antimicrobial activity. The poly(-caprolactone) microspheres prepared using a fluidic device (fluidic device microspheres) had a uniform diameter and a smooth surface, whereas the poly(-caprolactone) microspheres prepared using conventional homogenization (conventional homogenizatio...
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Ryu, T.-K., Kim, S. E., Kim, J.-H., Moon, S.-K., Choi, S.-W. Tags: Original Articles Source Type: research

Targeting of poly(L-lysine) to organs that propagate prions
Poly(l-lysine) was recently discovered to inhibit prion propagation. To develop poly(l-lysine) as a potential therapeutic for prion diseases, the understanding of in vivo poly(l-lysine) behavior is pivotal. Therefore, to determine the poly(l-lysine) distribution in mouse spleen and brain, the primary and ultimate target organs for prions, we performed non-invasive longitudinal in vivo imaging and time course on live mice and ex vivo imaging on mouse organs to confirmed poly(l-lysine) was distributed, including the brain and spleen. By studying the in vivo and ex vivo fluorescence images, characteristic patterns of poly(l-l...
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Lee, H.-M., Ryou, C. Tags: Original Articles Source Type: research

Dual passively active tumor-targeting micelles for pH-triggered intracellular anticancer drug release
Novel passive–active dual tumor-targeting micelles for pH-triggered intracellular nitrogen mustard release were developed based on hydrophobic cores conjugated with anticancer drugs and shells functionalized with folic acid ligands for tumor cell targeting. The amphiphilic triblock copolymer, 4-(bis(2-chloroethyl)amino)benzaldehyde, N-(2-hydroxypropyl)methacrylamide, and folic acid copolymer (poly(mustard-acetal)-b-PHPMA-b-PFA), was synthesized via reversible addition fragmentation chain transfer polymerization. The amphiphilic copolymer was subsequently self-assembled into nanosized micelles of 83 nm with the nitrog...
Source: Journal of Bioactive and Compatible Polymers - September 9, 2014 Category: Research Authors: Yuan, J., Xu, W., Chen, J., Zhao, J., Mu, Y., Wu, Y. Tags: Original Articles Source Type: research

Development of a silk fibroin/HTCC/PVA sponge for chronic wound dressing
A sponge wound dressing comprising silk fibroin, N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride, and polyvinyl alcohol was developed for chronic wound healing. These composite sponges were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The composite sponge had a fluid uptake of 80% of its weight, and the water vapor transmission rate of 2974 ± 684 g/m2/day, indicating that the sponge could keep a moist environment around the wound bed. The Wistar rats were used to evaluate these composites for the treatment of chronic wounds. Wound healing was monitored through...
Source: Journal of Bioactive and Compatible Polymers - July 9, 2014 Category: Research Authors: Li, X., Li, B., Ma, J., Wang, X., Zhang, S. Tags: Original Articles Source Type: research

Electrospun antibacterial nanofibrous polyvinylpyrrolidone/cetyltrimethylammonium bromide membranes for biomedical applications
Nanoscale structures with large surface area-to-volume ratios are used as biomaterial scaffolds for vascular grafts, wound dressings, and air purifying filters. Using electrospinning, nanofibers containing an antibacterial agent, cetyltrimethylammonium bromide, were prepared for wound healing application. Polyvinylpyrrolidone, known as a biocompatible additive in food and drug industries, has been used as fiber processing agent with the organic active ingredient, cetyltrimethylammonium bromide. A series of samples with different polyvinylpyrrolidone/ cetyltrimethylammonium bromide ratios were successfully prepared by this ...
Source: Journal of Bioactive and Compatible Polymers - July 9, 2014 Category: Research Authors: Uykun, N., Ergal, I., Kurt, H., Gokceoren, A. T., Gocek, I., Kayaoğlu, B. K., Akarsubaşı, A. T., Sarac, A. S. Tags: Original Articles Source Type: research