Journal of Bioactive and Compatible Polymers This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Collagen-carboxymethyl cellulose-tricalcium phosphate multi-lamellar cryogels for tissue engineering applications: Production and characterization
Collagen–carboxymethyl cellulose–tricalcium phosphate cryogels were prepared for diverse biomedical applications. Further chemical and structural characterizations were performed by Fourier transform infrared spectra, thermogravimetric analysis, X-ray crystallography, and scanning electron microscopy. The mechanical properties were tested by unconfined compression test. Moreover, hemocompatibility of the cryogels was also evaluated by basic biochemical blood testing. Chemical and structural analysis results demonstrate the achievement of the cross-linking without any major alteration in collagen and carboxymeth...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: Odabas, S. Tags: Original Articles Source Type: research

Managing bacterial biofilms with chitosan-based polymeric nitric oxides: Inactivation of biofilm bacteria and synergistic effects with antibiotics
In this study, we developed a new approach in the preparation of chitosan-based polymeric nitric oxides. Chitosan film (unreacted chitosan) reacted with glutaraldehyde to introduce aldehyde groups onto the material surface (glutaraldehyde-treated chitosan). Glutaraldehyde-treated chitosan reacted with a small-molecule nitric oxide donor, 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene, to covalently immobilize nitric oxide–releasing moieties onto the polymer (chitosan-based polymeric nitric oxide). Chitosan-based polymeric nitric oxide showed sustained release of nitric oxide. The activation energies and rate constant...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: Tang, R., Jiang, F., Wen, J., Deng, Y., Sun, Y. Tags: Original Articles Source Type: research

Micropatterned fabrication of chitosan-based thermoresponsive membranes for improving cell adhesion and gene expression
A simple, rapid, and economical method to fabricate micropatterned thermoresponsive chitosan membranes was developed. Porous polystyrene films were prepared by liquid-induced phase separation. The size of pores on polystyrene films could be regulated by adjusting the composition of coagulation bath and changing the solvent evaporation rate. Subsequently, chitosan-based thermoresponsive membranes with island protrusions were fabricated using porous polystyrene films as templates. The effects of the micropatterns on the behaviors of mouse fibroblast L929 were investigated. The presence of micropatterns altered the cell cycle...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: He, X.-L., Zhao, Y.-X., Ge, L.-L., An, H.-q., Su, Y., Jin, Z.-L., Wei, D.-S., Chen, L. Tags: Original Articles Source Type: research

Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells
In this study, we examined whether blood-compatible poly(2-methoxyethyl acrylate) and poly(tetrahydrofurfuryl acrylate) allow the adhesion and growth of A549 lung cancer cells for isolating circulating tumor cells by adhesion-mediated manner to diagnose metastatic cancer and to decide on the chemotherapeutic course. A549 cells can adhere on poly(2-methoxyethyl acrylate) and poly(tetrahydrofurfuryl acrylate) substrates via an integrin-dependent mechanism after 1 h of incubation, suggesting that blood-compatible poly(2-methoxyethyl acrylate) and poly(tetrahydrofurfuryl acrylate) substrates possess the ability to capture circ...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: Hoshiba, T., Nikaido, M., Yagi, S., Konno, I., Yoshihiro, A., Tanaka, M. Tags: Original Articles Source Type: research

Dual fluorescent N-(2-hydroxypropyl) methacrylamide-based conjugates for passive tumor targeting with reduction-sensitive drug release: Proof of the concept, tumor accumulation, and biodistribution
In this study, we synthesized, characterized, and investigated the in vivo fate of N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with a drug model bound via a disulfide bond, which is frequently cited in the literature as being completely stable in the bloodstream but readily cleaved after cell internalization. The concept was based on a "dual" labeling of N-(2-hydroxypropyl)methacrylamide copolymers with two different fluorescent dyes, where the first dye was linked via a disulfide bond, thus representing a model drug, while the second dye was attached as an amide and served as a label for the polymer carrier...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: Studenovsky, M., Heinrich, A.-K., Lucas, H., Mueller, T., Mäder, K., Etrych, T. Tags: Original Articles Source Type: research

Human-applicable dendrigraft poly-L-lysine-based nanoparticle-coated Plasmodium yoelii-transamidase DNA vaccine is immunogenic and protective as the polyethylenimine-based formulation
The objective was to assess the immunoequivalence and protective efficacy of the novel, relatively safe dendrigraft poly-l-lysine-based nanoparticle formulation in comparison to the non-degradable polyethylenimine-based system. Groups of 6-week-old female C57BL/6 mice were immunized three times biweekly. Each mouse received 100 µg of the Plasmodium yoelii GPI8p-transamidase PyTAM formulated with nanoball that consisted of PyTAM/PEI/-PGA or PyTAM/DGL/-PGA and their respective nanoparticle-coated blank vector controls. Two weeks after the last immunization, the humoral responses and cellular immune response were assess...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: Cherif, M. S., Mbanefo, E. C., Shuaibu, M. N., Kodama, Y., Avenido, E. F., Campos-Alberto, E., Mizukami, S., Camara, F., Helegbe, G. K., Kikuchi, M., Yanagi, T., Sasaki, H., Huy, N. T., Karbwang, J., Hirayama, K. Tags: Original Articles Source Type: research

Combined effects of drugs and plasticizers on the properties of drug delivery films
Formation of scar tissue may be reduced or prevented if wounds are locally treated with a combination of molecules tuned to the different healing phases, guiding tissue regeneration along a scar free path. To this end, drug delivery devices made of cellulose acetate phthalate and Pluronic F-127 were loaded with either quercetin or pirfenidone and plasticized with either triethyl citrate or tributyl citrate. Quercetin inhibits oxidative stress, and pirfenidone has been shown to reduce production of pro-inflammatory and fibrogenic molecules. The combined effects of drug and plasticizer on erosion, release, and mechanical pro...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: Jennings, C. L., Dziubla, T. D., Puleo, D. A. Tags: Original Articles Source Type: research

Modified chitosan scaffolds: Proliferative, cytotoxic, apoptotic, and necrotic effects on Saos-2 cells and antimicrobial effect on Escherichia coli
In this study, novel micro-fibrous chitosan scaffolds, having mineralized bioactive surface to enhance cell adhesion and a model antibiotic (gentamicin) to prevent bacterial attack, were prepared. The effects of the scaffolds on proliferation, viability, apoptosis, and necrosis of Saos-2 cells are reported for the first time. Wet spinning technique was used in the scaffold preparation and biomineralization was achieved by incubating them in five-time concentrated simulated body fluid for 2, 7, or 14 days (coded as CH-BM/2, CH-BM/7, and CH-BM/14, respectively). Gentamicin, an effectively used antibiotic in bone treatments, ...
Source: Journal of Bioactive and Compatible Polymers - April 18, 2016 Category: Research Authors: Ucar, S., Ermis, M., Hasirci, N. Tags: Original Articles Source Type: research

Covalent streptavidin immobilization on electrospun poly(m-anthranilic acid)/polycaprolactone nanofibers and cytocompatibility
An electrospun poly(m-anthranilic acid)/poly(-caprolactone) nanofiber mat was fabricated with functionalization of the surface with streptavidin which can enhance the cell attachment and proliferation. Poly(-caprolactone) as biodegradable, biocompatible, and electrospinnable polymer was blended with poly(m-anthranilic acid) because of the carboxylic acid (–COOH) groups on its backbone which allow the covalent immobilization of streptavidin onto nanofibers. 1-Ethyl-3-(dimethyl-aminopropyl) carbodiimide hydrochloride/N-hydroxyl succinimide coupling reaction was used for immobilization and the presence of bound protein ...
Source: Journal of Bioactive and Compatible Polymers - April 18, 2016 Category: Research Authors: Polat, E., Güler, Z., Balkan, T., Sarac, A. S. Tags: Original Articles Source Type: research

Three-dimensional scaffold of gelatin-poly(methyl vinyl ether-alt-maleic anhydride) for regenerative medicine: Proliferation and differentiation of mesenchymal stem cells
This study shows, for the first time, the ability of a composite scaffold of gelatin and poly(methyl vinyl ether-alt-maleic anhydride) (GP-2) as a niche for expansion and multilineage differentiation ability of human umbilical cord–derived mesenchymal stem cells. First, the in vivo biocompatibility of scaffolds was checked by subcutaneous implantation of scaffolds in male Wistar rats for up to 45 days. Hematological parameters and histology of skin near implanted region rule out the probability of any adverse effects due to the scaffolds. The isolated human umbilical cord–derived mesenchymal stem cells were see...
Source: Journal of Bioactive and Compatible Polymers - April 18, 2016 Category: Research Authors: Chhabra, H., Kumbhar, J., Rajwade, J., Jadhav, S., Paknikar, K., Jadhav, S., Bellare, J. R. Tags: Original Articles Source Type: research

A controlled release system for quercetin from biodegradable poly(lactide-co-glycolide)-polycaprolactone nanofibers and its in vitro antitumor activity
Quercetin is a potent natural antioxidant but has limited therapeutic applications due to its short half-life in body fluids. In order to improve the efficacy of quercetin and overcome its shortcomings, quercetin-encapsulated electrospun poly(lactic-co-glycolic acid)–poly(-caprolactone) nanofibrous controlled release system was developed using electrospinning technique. Fourier transform infrared spectroscopy, thermogravimetric, and X-ray diffraction analysis suggested the incorporation, thermal stability, and existence of encapsulated quercetin in semicrystalline state in the nanofibers. The release profiles of quer...
Source: Journal of Bioactive and Compatible Polymers - April 18, 2016 Category: Research Authors: Vashisth, P., Singh, R. P., Pruthi, V. Tags: Original Articles Source Type: research

Antimicrobial and biocompatible {varepsilon}-polylysine-{gamma}-poly(glutamic acid)-based hydrogel system for wound healing
In conclusion, antimicrobial and biocompatible -polylysine–-poly(glutamic acid) composite may have great application for wound healing. (Source: Journal of Bioactive and Compatible Polymers)
Source: Journal of Bioactive and Compatible Polymers - April 18, 2016 Category: Research Authors: Wang, R., Zhou, B., Xu, D.-l., Xu, H., Liang, L., Feng, X.-h., Ouyang, P.-k., Chi, B. Tags: Original Articles Source Type: research

Drug loading and release kinetics in polymeric micelles: Comparing dynamic versus unimolecular sugar-based micelles for controlled release
Amphiphilic macromolecules, possessing sugar-based hydrophobic and poly(ethylene glycol) hydrophilic domains, provide tunable structures that form effective polymeric micellar drug delivery systems. In this work, we compare traditional dynamic micelles and covalently bound unimolecular amphiphilic macromolecule micelles to study the effects of amphiphilic macromolecule hydrophobic domain branching, micelle architecture, and hydrodynamic volume of two drugs (triclosan and suloctidil) to elucidate the micellar structure–property relationships that govern drug loading and release kinetics. Overall, more hydrophobic mice...
Source: Journal of Bioactive and Compatible Polymers - April 18, 2016 Category: Research Authors: Tao, L., Chan, J. W., Uhrich, K. E. Tags: Original Articles Source Type: research

Electrospun silk fibroin-poly (lactic-co-glycolic acid) membrane for nerve tissue engineering
Silk fibroin–poly(lactic-co-glycolic acid) fibrous membranes were electrospun by varying the weight ratios for silk fibroin to poly(lactic-co-glycolic acid). The hydrophilicity, mechanical property, and biodegradability of the fibrous in vitro were evaluated. Contact angle test demonstrated that the hydrophilicity of poly(lactic-co-glycolic acid) fibrous membrane could be improved by introducing silk fibroin ingredient. Mechanical test showed that the strain–elongation performances of silk fibroin–poly(lactic-co-glycolic acid) fibrous can be controlled by changing the silk fibroin percentage. 3-(4,5-Dimet...
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Zhan, J., Liu, J., Wang, C., Fan, C., EI-Hamshary, H. A., Al-Deyab, S. S., Mo, X. Tags: Original Articles Source Type: research

Functionality of surface-coupled oxidised glycosaminoglycans towards fibroblast adhesion
Glycosaminoglycans are able to bind many growth factors and adhesive proteins, which affect cell activities such as adhesion, migration, growth and differentiation. Chondroitin sulphate, hyaluronan, sulphated hyaluronan and heparin were oxidised here (aldehyde glycosaminoglycans) to generate aldehydes on vicinal hydroxyl groups of the uronic monomers of glycosaminoglycans for subsequent direct covalent binding to amino-terminated model substrata. The properties of modified surfaces were monitored by water contact angle, zeta potential, ellipsometry measurements and atomic force microscopy showing successful immobilisation ...
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Yang, Y., Köwitsch, A., Ma, N., Mäder, K., Pashkuleva, I., Reis, R. L., Groth, T. Tags: Original Articles Source Type: research