Journal of Bioactive and Compatible Polymers This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Fabrication and biological evaluation in vivo of an injectable keratin hydrogel as filler materials
Filler materials of soft tissue should have good biodegradable absorption and biocompatibility. To investigate feasibility of keratin hydrogels used as filler materials, a keratin with high molecular weight and self-assembly ability was extracted from human hair using a modified reduction method and was characterized using sodium dodecyl sulfate–polyacrylamide gel electrophoresis, Fourier transform infrared, and X-ray diffraction. An injectable keratin hydrogel was also prepared and its water absorption, cell toxicity, and histological behavior were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium br...
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Xu, S., Zhang, C., Zhang, A., Wang, H., Rao, H., Zhang, Z. Tags: Original Articles Source Type: research

Facile fabrication of highly soluble, extremely small-sized drug carriers using globular poly(ethylene glycol)
We report extremely small-sized drug-carrying globular poly(ethylene glycol) particles. These particles were prepared using fullerene (C60) as a backbone structure and poly(ethylene glycol) as a hydrophilic shell. All – carbon bonds in C60 were combined with poly(ethylene glycol), which form a "globular nano-cage" with a hollow core (originating from the soccer-ball-shaped truncated icosahedron of C60) and the poly(ethylene glycol) shell. Subsequently, we constructed chlorin e6-conjugated globular poly(ethylene glycol). The obtained globular poly(ethylene glycol)–chlorin e6 (average 3.6 nm in diameter) was solu...
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Lee, M., Lee, D. J., Youn, Y. S., Lee, E. S. Tags: Original Articles Source Type: research

Optimization of sterilization methods for electrospun poly({varepsilon}-caprolactone) to enhance pre-osteoblast cell behaviors for guided bone regeneration
The aim of this study was to determine the optimal sterilization procedure for biodegradable polyester-based guided bone regeneration membranes. The effects of sterilization using low-temperature hydrogen peroxide gas plasma, 75% ethanol (EtOH; two soaking times), and ultraviolet radiation on the structure and biological properties of electrospun poly(-caprolactone) membranes were investigated. The results demonstrated that all were effective sterilization methods. The membranes were then assessed for surface structure, wettability, and in vitro cellular responses including osteogenic differentiation by seeding with pre-os...
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Dai, Y., Xia, Y., Chen, H.-B., Li, N., Chen, G., Zhang, F.-M., Gu, N. Tags: Original Articles Source Type: research

Use of salicylic acid polymers and bone morphogenetic protein-2 to promote bone regeneration in rabbit parietal bone defects
The ability of bone defects to heal spontaneously is inversely related to the size of the defect, such that defects larger than a critical size will not heal without additional therapeutic intervention. Typically, large bone defects are filled with autologous bone harvested from another skeletal site, an osteoconductive bone graft material, treated with an osteoinductive factor such as bone morphogenetic protein-2, or by a combination of these approaches. Despite these interventions, unsatisfactory success and complication rates show that alternative treatment methods are needed. Here, we test whether salicylic acid polyme...
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Mitchell, A., Kim, B., Snyder, S., Subramanian, S., Uhrich, K., OConnor, J. P. Tags: Original Articles Source Type: research

Poly(ester-anhydride) for controlled delivery of hydrophilic drugs
Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70 w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28 days. (Source: Journal of...
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Ickowicz, D. E., Abtew, E., Khan, W., Golovanevski, L., Steinman, N., Weiniger, C. F., Domb, A. J. Tags: Original Articles Source Type: research

Rosin: Recent advances and potential applications in novel drug delivery system
This article reviews the literature on rosin and its derivative and describes the varied applications of the rosin and their future exploitation in novel drug delivery systems. (Source: Journal of Bioactive and Compatible Polymers)
Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Yadav, B. K., Gidwani, B., Vyas, A. Tags: Communication Source Type: research

Plasma-activated fibrinogen coatings onto poly(vinylidene fluoride) surface for improving biocompatibility with tissues
CO2, N2, and N2/H2 radiofrequency plasma exposure was used for functionalization of poly(vinylidene fluoride) surface aiming the fibrinogen immobilization. Fibrinogen was immobilized onto poly(vinylidene fluoride) surface using both simple plasma activation and covalent coupling. The modified surfaces have been characterized by X-ray photoelectron spectroscopy, attenuated total reflectance–Fourier transform infrared spectroscopy, near infrared–chemical imaging, atomic force microscopy, and wettability measurements, and the obtained materials were tested as supports for fibroblast cell cultures. The plasma type ...
Source: Journal of Bioactive and Compatible Polymers - December 17, 2015 Category: Research Authors: Stoleru, E., Baican, M. C., Coroaba, A., Hitruc, G. E., Lungu, M., Vasile, C. Tags: Original Articles Source Type: research

Immobilization of heparin on chitosan-grafted polyurethane films to enhance anti-adhesive and antibacterial properties
In this study, polyurethane (PU), which is the most commonly used polymer in the production of medical devices, was synthesized and surfaces of polyurethane films were modified by chitosan (CH) grafting and heparin (Hep) immobilization in order to enhance anti-adhesiveness and antibacterial properties. Functional groups present on the surface, topographical shapes, and free energies of the polyurethane films were determined. Pristine polyurethane, chitosan-grafted polyurethane (PU–CH), and heparin immobilized polyurethane (PU–CH–Hep) films demonstrated high anti-adhesive efficacy against bacteria in the g...
Source: Journal of Bioactive and Compatible Polymers - December 17, 2015 Category: Research Authors: Kara, F., Aksoy, E. A., Calamak, S., Hasirci, N., Aksoy, S. Tags: Original Articles Source Type: research

Antibacterial nanofibrous scaffolds with lowered cytotoxicity using keratin extracted from quail feathers
This study aims to extract keratin from quail feather wastes and incorporate it with silver nanoparticles into a synthetic biodegradable polymer in order to fabricate a nanofibrous scaffold with improved biomedical properties. Polyvinyl alcohol was used as the host polymer and spinning dopes with different amounts (0, 0.15, and 0.75 wt %) of extracted keratin and the same amount of silver nanoparticles prepared in order to fabricate scaffolds. According to the results, the scaffolds with a higher amount of extracted keratin (i.e. 0.75 wt %) provided less bead formation and more uniformity; also, they gave 99.9% and 98% of ...
Source: Journal of Bioactive and Compatible Polymers - December 17, 2015 Category: Research Authors: Khajavi, R., Rahimi, M. K., Abbasipour, M., Brendjchi, A. H. Tags: Original Articles Source Type: research

Novel Dioscorea hispida starch-based hydrogels and their beneficial use as disinfectants
Starch-grafted polyacrylamide hydrogels were successfully prepared via chemical polymerization method in basic solution, which provides a homogeneous suspension in the reaction system. The results obtained from Fourier transform infrared–attenuated total reflectance confirmed that the monomer polyacrylamide was grafted onto the starch backbone as shown by the cross-linked peak at 1638 cm–1. Scanning electron microscopy showed that the morphology of starch-grafted polyacrylamide hydrogels has a highly porous structure which provides excellent water absorption capacity with a swelling ratio up to 124%. The X-ray ...
Source: Journal of Bioactive and Compatible Polymers - December 17, 2015 Category: Research Authors: Azman, I., Mutalib, S. A., Yusoff, S. F. M., Fazry, S., Noordin, A., Kumaran, M., Mat Lazim, A. Tags: Original Articles Source Type: research

Effect of enzymatically cross-linked tilapia scale collagen for osteoblastic differentiation of human mesenchymal stem cells
In this study, fish collagen derived from tilapia scales which are free from the risk of infection was employed to fabricate a three-dimensional porous scaffold. Tilapia scale collagen scaffolds were modified using microbial transglutaminase enzyme as a catalyst to preserve the inherent properties of collagen material. Human mesenchymal stem cells were incubated with various substitutes including tilapia scale collagen and porcine collagen–coated cell culture dishes with or without microbial transglutaminase, tilapia scale collagen, and porcine collagen scaffolds cross-linked by microbial transglutaminase. Differenti...
Source: Journal of Bioactive and Compatible Polymers - December 17, 2015 Category: Research Authors: Oh, H. H., Uemura, T., Yamaguchi, I., Ikoma, T., Tanaka, J. Tags: Original Articles Source Type: research

Tailored star poly ({varepsilon}-caprolactone) wet-spun scaffolds for in vivo regeneration of long bone critical size defects
In this study, polymeric fibrous scaffolds with a controlled internal network of pores and modelled on the anatomical shape and dimensions of a critical size bone defect in a rabbit’s radius model were developed by employing a computer-aided wet-spinning technique. The tailored scaffolds made of star poly(-caprolactone) or star poly(-caprolactone)–hydroxyapatite composite material were implanted into 20-mm segmental defects created in radial diaphysis of New Zealand white rabbits. Bone regeneration and tissue response were assessed by X-rays and histological analysis at 4, 8 and 12 weeks after surgery. No signs...
Source: Journal of Bioactive and Compatible Polymers - December 17, 2015 Category: Research Authors: Dini, F., Barsotti, G., Puppi, D., Coli, A., Briganti, A., Giannessi, E., Miragliotta, V., Mota, C., Pirosa, A., Stornelli, M. R., Gabellieri, P., Carlucci, F., Chiellini, F. Tags: Original Articles Source Type: research

The effect of stereocomplex polylactide particles on the mechanical properties of poly(lactide-co-glycolide) copolymer
The effect of the addition of stereocomplex polylactide with different contents and particle sizes to a poly(lactide-co-glycolide) matrix was investigated. The organic filler stereocomplex polylactide affects the mechanical properties of poly(lactide-co-glycolide) as an organic nucleating agent without any surface modification. A low content of organic stereocomplex polylactide particles in the poly(lactide-co-glycolide) blends enhanced their mechanical properties. A smaller stereocomplex polylactide particle size improves the mechanical properties of poly(lactide-co-glycolide) blends more effectively. The improvement in t...
Source: Journal of Bioactive and Compatible Polymers - December 17, 2015 Category: Research Authors: Ye, K., Purnama, P., Jung, Y., Kim, D., Kim, S. H. Tags: Original Articles Source Type: research

Inosculation potential of angiopoietin-4-immobilized pHEMA-based bone scaffolds
In this study, vascularization potential of angiopoietin-4 either alone or in combination with vascular endothelial growth factor (VEGF) was investigated following its immobilization onto the poly(2-hydroxyethyl methacrylate)-based bone scaffolds. Poly(2-hydroxyethyl methacrylate) (pHEMA)-based superporous hydrogels (SPHs) were synthesized by radical polymerization of hydroxyethyl methacrylate in the presence of gelatin or chitosan and the porosity was achieved by gas foaming. However, only pHEMA-gelatin SPHs fulfill the structural and biological characteristics of a bone scaffold. Therefore, angiopoietin-4 and/or VEGF wer...
Source: Journal of Bioactive and Compatible Polymers - October 8, 2015 Category: Research Authors: Gumusderelioglu, M., Karakus, E., Capkın Yurtsever, M., Altındal, D. C. Tags: Original Articles Source Type: research

Preparation and characterization of silk fibroin/poly(L-lactide-co-{varepsilon}-caprolactone) nanofibrous membranes for tissue engineering applications
In this study, in order to combine their respective characteristics, silk fibroin/poly(l-lactide-co--caprolactone) nanofibrous membranes were fabricated through electrospinning with different mass ratios of 100:0, 75:25, 50:50, 25:75, and 0:100. The surface properties, thermodynamic properties, mechanical properties, and cytocompatibility of silk fibroin/poly(l-lactide-co--caprolactone) blended membranes were evaluated, and an optimal blending ratio was identified. The results showed that the silk fibroin/poly(l-lactide-co--caprolactone) blended membranes containing 75% of silk fibroin and 25% of poly(l-lactide-co--caprola...
Source: Journal of Bioactive and Compatible Polymers - October 8, 2015 Category: Research Authors: Yao, Y., Liu, H., Ding, X., Jing, X., Gong, X., Zhou, G., Fan, Y. Tags: Original Articles Source Type: research