Journal of Bioactive and Compatible Polymers This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Skin wound healing with chitosan thin films containing supported silver nanospheres
Dermal wound healing involves complex histo-molecular events aimed to repair the discontinuity of the epithelium. Employing nanometric silver particles provides an efficient antimicrobial effect for several dermal infections. The aim is to elucidate imminent advantages of silver nanoparticles, such as the possibility of modulating the epithelial cell repair process. Through the nanostructural implementation of chitosan thin films supporting silver nanoparticles, it was feasible to evaluate in vivo the efficacy and evolution of dermal recuperation after surgical damage. The characterization of chitosan silver nanoparticle f...
Source: Journal of Bioactive and Compatible Polymers - October 8, 2015 Category: Research Authors: Ojeda-Martinez, M. L., Yanez-Sanchez, I., Velasquez-Ordonez, C., Martinez-Palomar, M. M., Alvarez-Rodriguez, A., Garcia-Sanchez, M. A., Rojas-Gonzalez, F., Galvez-Gastelum, F. J. Tags: Original Articles Source Type: research

Electroactive hybrid hydrogel: Toward a smart coating for neural electrodes
Electroactive hybrid hydrogels, composed of single-walled carbon nanotubes, polypyrrole, and poly(ethylene glycol) diacrylate–polyacrylamide, were synthesized on titanium-mesh electrodes via interfacial polymerization. The modified electrodes can be used as controlled drug delivery system by applying an external electrical stimulation of cyclic voltammetry. Investigations revealed that single-walled carbon nanotubes acted as nucleators in the hybrid hydrogel and facilitated the formation of a continuous and uniform polypyrrole coating. Simultaneous incorporation of single-walled carbon nanotubes and polypyrrole impro...
Source: Journal of Bioactive and Compatible Polymers - October 8, 2015 Category: Research Authors: Zhang, D., Di, F., Zhu, Y., Xiao, Y., Che, J. Tags: Original Articles Source Type: research

Synthesis and characterization of {beta}-cyclodextrin-conjugated alginate hydrogel for controlled release of hydrocortisone acetate in response to mechanical stimulation
Alginate hydrogels are a class of biomaterials that can be used as local release depots for therapeutic agents. A particular drug that can take advantage of alginate hydrogel for controlled release is hydrocortisone acetate. Hydrocortisone acetate is a widely used anti-inflammatory agent, but is limited in application due to poor solubility and lack of controlled delivery. To overcome this limitation, a mechanically responsive β-cyclodextrin-conjugated alginate (Alg-β-CD) hydrogel was synthesized and characterized for enhanced aqueous solubility and controlled release of hydrocortisone acetate. We demonstrated th...
Source: Journal of Bioactive and Compatible Polymers - October 8, 2015 Category: Research Authors: Tan, L., Li, J., Liu, Y., Zhou, H., Zhang, Z., Deng, L. Tags: Original Articles Source Type: research

Physicochemical, molecular, and biological properties of complexes formed between aminoglycoside antibiotics and some anionic copolymers of acrylic series: Part II
Physicochemical and molecular properties of complexes formed by aminoglycoside antibiotics, including neomycin, gentamicin, kanamycin, and amikacin, in the form of bases and carboxyl- or sulfo-comprising copolymers of acrylamide or N-(2-hydroxypropyl)methacrylamide have been studied. The toxicity of complexes in vitro and their antimicrobial activity are matched to their behavior in solutions. Direct dependency of toxic and antibacterial properties of polymer complexes of aminoglycoside antibiotics on their molecular characteristics and stability opens up perspectives of targeting control over their antimicrobial activity ...
Source: Journal of Bioactive and Compatible Polymers - October 8, 2015 Category: Research Authors: Tarabukina, E. B., Solovskii, M. V., Pautov, V. D., Amirova, A. I., Zakharova, N. V., Smirnova, M. Y., Anan'eva, T. D., Imanbaev, R. T., Eropkin, M. Y., Eropkina, E. M. Tags: Original Articles Source Type: research

Depth (Z-axis) control of cell morphologies on micropatterned surfaces
In this study, cell responses on micropatterned films that were changing in groove–ridge widths and pattern depth were investigated to compare the degree of size effects from X–Y and Z planes. Poly(caprolactone) films with five different groove–ridge sizes and three pattern depths were prepared by hot embossing technique. In general, the morphologies of osteoblast cell were not changed noticeably by the size changes in groove–ridges with the same depth size. However, cell morphologies were changed significantly when pattern depths were increased from 1.35 to 4.95 µm. Also, the cell morphology ...
Source: Journal of Bioactive and Compatible Polymers - September 4, 2015 Category: Research Authors: Baran, E. T., Pirraco, R. P., Cerqueira, M. T., Marques, A. P., Retolaza, A., Merino, S., Neves, N. M., Reis, R. L. Tags: Original Articles Source Type: research

Effect of cyclodextrins on the structure and functions of blood components in vitro
In this study, we investigated the influences of cyclodextrins (α-cyclodextrin, β-cyclodextrin, and -cyclodextrin) on human blood components and functions in vitro, that is, morphology and lysis of red blood cells, structure and conformation of fibrinogen, complement activation, and blood coagulation. It was found that 10 mg/mL of α- or β-cyclodextrins caused abnormal red blood cell morphology and serious hemolysis, while -cyclodextrin at 10 mg/mL did not impair red blood cell membrane morphology and integrity. The three cyclodextrins at up to 10 mg/mL affected the local microstructure but did not cha...
Source: Journal of Bioactive and Compatible Polymers - September 4, 2015 Category: Research Authors: Fu, Y., Wang, X., Zhang, Y., Liu, Z., Xue, W. Tags: Original Articles Source Type: research

Covalently cross-linked hydroxyapatite-citric acid-based biomimetic polymeric composites for bone applications
This study involved two biomimetic composites, 3CP-VP and 5CP-VP, prepared by varying the concentration of hydroxyapatite. Uniform homogenous distribution of hydroxyapatite was identified through Raman spectral imaging in both the composite matrices. The compressive moduli of the biomimetic composites after 4-week immersion in phosphate-buffered saline ranged between 100 and 300 MPa, which falls well within the accepted values reported for human trabecular bone. Moreover, biodegradation studies revealed only an average weight loss of 10%–17% during the 7-week time period. Furthermore, apatite mineralization was evalu...
Source: Journal of Bioactive and Compatible Polymers - September 4, 2015 Category: Research Authors: Victor, S. P., VM, V., Komeri, R., Selvam, S., Muthu, J. Tags: Original Articles Source Type: research

Electrospun/electrosprayed polyurethane biomembranes with ciprofloxacin and clove oil extract for urinary devices
Polyurethane–eugenol solutions in N,N-dimethyl formamide were electrospun/electrosprayed onto polyurethane–ciprofloxacin biomembranes to obtain drug delivery systems for urinary devices. Following electrospinning/electrospraying, particle-fiber morphology was evidenced by scanning electronic microscope analysis. Contact angle determinations along with surface free energy calculations, moisture diffusion test, and diffusion coefficient determinations were done for polyurethane–ciprofloxacin biomembranes. Determination of bioactive ciprofloxacin release kinetics evidences non-Fickian/anomalous/diffusion mec...
Source: Journal of Bioactive and Compatible Polymers - September 4, 2015 Category: Research Authors: Macocinschi, D., Filip, D., Vlad, S., Cernatescu, C., Tuchilus, C. G., Gafitanu, C. A., Dumitriu, R. P. Tags: Original Articles Source Type: research

Evaluation of silk fibroin protein/poly(vinyl alcohol) transparent membranes as prospective patch for acne care
In this work, the drop-casting method was used to mix silk with poly(vinyl alcohol) to generate a composite membrane silk fibroin protein/poly(vinyl alcohol) transparent membrane, whose porosity and permeability can be controlled by adding (or not adding) NaCl, for increasing its permeability. The silk fibroin protein/poly(vinyl alcohol) transparent membranes did not exhibit significant cytotoxicity when an appropriate amount of tea tree oil was added. When the volume of tea tree oil that was added to the non-porous silk fibroin protein membrane or porous silk fibroin protein membrane increased above 12.50 µL/patch, ...
Source: Journal of Bioactive and Compatible Polymers - September 4, 2015 Category: Research Authors: Bai, M.-Y., Hsueh, Y.-W. Tags: Original Articles Source Type: research

Blends of shellac as nanofiber formulations for wound healing
Shellac is being used in food, pharmaceutical, and agricultural industries. It is seldom used for biomedical applications due to its poor mechanical property and instability. We designed thermoresponsive shellac-based bioactive nanofiber mats that mimic extracellular matrix to extend their utility in wound healing. Various blend compositions of shellac, gelatin, and poly(N-isopropylacrylamide) enriched with a bioactive agent, nadifloxacin, were prepared and nanofiber mats were fabricated. The morphology of the nanofiber formation was influenced by the concentration of polymer, drug, and polymer blend composition. Polymer&n...
Source: Journal of Bioactive and Compatible Polymers - September 4, 2015 Category: Research Authors: Vannuruswamy, G., Rathna, G. V. N., Gadgil, B. S. T., Gadad, A. P. Tags: Original Articles Source Type: research

Biocompatibility of Dead Sea Water and retinyl palmitate carrying poly(3-hydroxybutyrate-co-3-hydroxyvalerate) micro/nanoparticles designed for transdermal skin therapy
In conclusion, these carriers have shown a significant potential as topical drug delivery systems in the personalized treatment of skin diseases because their contents could be modified according to a patient’s needs and several drugs could be loaded in one type of microparticle, or several populations, each carrying a different drug, can be used in the treatment. (Source: Journal of Bioactive and Compatible Polymers)
Source: Journal of Bioactive and Compatible Polymers - September 4, 2015 Category: Research Authors: Eke, G., Goni-de-Cerio, F., Suarez-Merino, B., Hasirci, N., Hasirci, V. Tags: Original Articles Source Type: research

A combined rotational mold for manufacturing a functional liver system
A combined rotational mold system for liver manufacturing was prepared. The combined rotational mold system was composed of a branched internal mold, a basement mold, and a series of external molds with increasing diameters. Semi-spindle constructs, consisting of multiple cell types, such as adipose-derived stem cells and hepatocytes encapsulated in a fibrin hydrogel, were created by sequentially sandwiching cell-laden fibrin hydrogels between the combined rotational mold system based on the Weissenberg effect of non-Newtonian fluid. A spindle liver lobe precursor was constructed, with a multi-scale vascular network includ...
Source: Journal of Bioactive and Compatible Polymers - June 17, 2015 Category: Research Authors: Wang, X., Huang, Y., Liu, C. Tags: Original Articles Source Type: research

Bilayer electrospun poly(vinyl alcohol)-gelatin mat and biphasic calcium phosphate-pectin-gelatin hydrogel for application in bone hemorrhage
A bilayer composite scaffold consisting of a biphasic calcium phosphate–pectin–gelatin hydrogel and an electrospun poly(vinyl alcohol)–gelatin matrix was developed and investigated for application in bone hemorrhage. The aim of this research is to develop a new biomaterial system that provides a hemostatic effect on bone hemorrhage and does not interfere with native bone regeneration. The role of electrospun poly(vinyl alcohol)–gelatin in scaffolds is to provide the covering of the wound, while encapsulation and absorption of red blood cells are attributed to the biphasic calcium phosphate–pec...
Source: Journal of Bioactive and Compatible Polymers - June 17, 2015 Category: Research Authors: Linh, N. T. B., Padalhin, A. R., Lee, B.-Y., Lee, B.-T. Tags: Original Articles Source Type: research

Enzyme-mediated fabrication of an oxidized chitosan hydrogel as a tissue sealant
In this study, we introduce a new type of chitosan-based hydrogel as a tissue sealant, which was prepared by enzymatic mediation from periodate-oxidized chitosan–polyethylene glycol–tyramine. The oxidized chitosan backbone was expected to enhance the interconnection between the hydrogel layer and collagen in the tissues via the Schiff-base reaction. Proton nuclear magnetic resonance spectra indicated that tyramine-functionalized polyethylene glycol-nitrophenyl carbonate ester was conjugated to the oxidized chitosan. The degree of oxidation of the chitosan backbone was around 14% of the glucosamine units by prot...
Source: Journal of Bioactive and Compatible Polymers - June 17, 2015 Category: Research Authors: Phuong, N. T., Anh Ho, V., Hai Nguyen, D., Khoa, N. C., Quyen, T. N., Lee, Y., Park, K. D. Tags: Original Articles Source Type: research

Fabrication and characterization of carboxymethyl chitosan/poly(vinyl alcohol) hydrogels containing alginate microspheres for protein delivery
In this research, a novel drug delivery system consisting of alginate microspheres and carboxymethyl chitosan/poly(vinyl alcohol) hydrogel was developed for prolonged and sustained controlled drug release. The alginate microspheres and various volume ratios of carboxymethyl chitosan were incorporated physically into poly(vinyl alcohol) to form the composite system. Scanning electron microscope, rheometer, differential scanning calorimetry, and thermogravimetric analysis were used to investigate the morphological, rheological, and thermal properties. The adsorptivity and hydrogel content were evaluated by swelling ratio and...
Source: Journal of Bioactive and Compatible Polymers - June 17, 2015 Category: Research Authors: Liu, Q., Zuo, Q., Guo, R., Hong, A., Li, C., Zhang, Y., He, L., Xue, W. Tags: Original Articles Source Type: research