Journal of Bioactive and Compatible Polymers This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Improved poly(D,L-lactide-co-1,3-trimethylene carbonate)6 copolymer microparticle vehicles for sustained and controlled delivery of bioactive basic fibroblast growth factor
A novel, biocompatible and biodegradable six-arm branched copolymer poly(d,l-lactide)-co-(1,3-trimethylene carbonate)6 has been synthesized and fabricated as a porous microparticle with an oil-in-water single emulsion method. Poly(d,l-lactide-co-1,3-trimethylene carbonate)6 microparticles were further conjugated with heparin by 1-ethyl-3-3-dimethylamino-propylcarbodiimide/N-hydroxysuccinimide chemistry and characterized using 1H-nuclear magnetic resonance and scanning electron microscopy. The heparin-loading capacity of poly(d,l-lactide-co-1,3-trimethylene carbonate)6 microparticles was identified as 213 ± 6 pmol/mg...
Source: Journal of Bioactive and Compatible Polymers - June 17, 2015 Category: Research Authors: Gao, M., Zeng, C., Zhu, A., Tao, H., Yang, L., Quan, D. Tags: Original Articles Source Type: research

Antimicrobial polymer composites with copper micro- and nanoparticles: Effect of particle size and polymer matrix
The addition of metal particles, for instance, silver or copper, into polymer matrices is a relevant strategy producing novel antimicrobial materials. By using two particles with diameters around 10 nm and 45 µm, and polymers with different characteristics, the effect of filler size and matrix on the biocide behavior of polymer/copper composites was studied. The composites were prepared by melt mixing, and the ion release from these materials was used to obtain critical information about the processes involved. Regarding the effect of the particle size, our results for polypropylene showed that this variable drastica...
Source: Journal of Bioactive and Compatible Polymers - June 17, 2015 Category: Research Authors: Palza, H., Quijada, R., Delgado, K. Tags: Original Articles Source Type: research

Core crosslinked H-type poly(methacrylic acid)-block-hydroxyl terminated polybutadiene-block-poly(methacrylic acid) four-armed star block copolymer micelles for intercellular drug release
H-type four-armed star block copolymers with hydroxyl-terminated polybutadiene as hydrophobic sections and poly(methacrylic acid) as hydrophilic fragments were synthesized through atom transform radical polymerization and the follow-up acidolysis, named PMAA2-b-HTPB-b-PMAA2. The core crosslinking reaction was conducted by ultraviolet light irradiation. 1H nuclear magnetic resonance, Fourier transform infrared, size exclusion chromatography, and thermal gravimetric analysis were adopted to confirm the chemical structure of the resulting copolymers. The effect of the ultraviolet light crosslinking on the physicochemical prop...
Source: Journal of Bioactive and Compatible Polymers - June 17, 2015 Category: Research Authors: Xu, J.-W., Xu, F., Luo, Y.-L. Tags: Original Articles Source Type: research

Injectable microspheres for extended delivery of bioactive insulin and salicylic acid
This study evaluates the in vivo effects of insulin-loaded, salicylate-based, biocompatible, biodegradable polymeric microspheres that gradually release salicylic acid and insulin simultaneously. The study is predicated on the knowledge that such a continuous delivery system can release insulin over an extended period of time and overcome the aforementioned issues. Additionally, salicylic acid reduces insulin resistance in type-2 diabetic patients. In this work, we observed that insulin and salicylic acid were detected in serum over an extended period of time (at least 12 h and 4 days, respectively), and mice receiving ins...
Source: Journal of Bioactive and Compatible Polymers - April 20, 2015 Category: Research Authors: Yu, W., Bien-Aime, S., Li, J., Zhang, L., McCormack, E. S., Goldberg, I. D., Narayan, P., Uhrich, K. E. Tags: Communication Source Type: research

In vitro and in vivo biocompatibility evaluation of a novobiocin stimulus-responsive poly(ethylene glycol)-based hydrogel designed for soft tissue regeneration
In vitro and in vivo biocompatibility evaluation of medical devices designed for soft tissue healing and regeneration is mandatory for new biomaterials targeted toward human application. To this end, a novel stimulus-responsive eight-arm poly(ethylene glycol) (PEG)-based hydrogel for soft tissue regeneration was subjected to preclinical safety evaluation. While in vitro safety testing included determination of half-maximal inhibitory concentrations by cell index impedance measurements, an in vivo pilot rat study focused on detectable signs of oral mucosal inflammation. In a hydrogel with a total volume of 40 µL, the ...
Source: Journal of Bioactive and Compatible Polymers - April 20, 2015 Category: Research Authors: Laird, D., El-Baba, M. D., Charpin-El Hamri, G., Eberwein, P., Nelson, K., Tomakidi, P., Steinberg, T. Tags: Original Articles Source Type: research

Enhanced osteoblast cells adhesion, spreading, and proliferation to surface-carboxylated poly(etheretherketone)
Poly(etheretherketone) is a rigid semicrystalline thermoplastic that combines excellent mechanical properties, broad chemical resistance, and bone-like stiffness, and is widely used in biomedical fields. However, the hydrophobic bio-inert surface of poly(etheretherketone) tends to hinder its biomedical applications when direct osteointegration between the implants and the host tissue is desired. In this investigation, poly(etheretherketone) surface was functionalized by a method with chemistry analogous to the formation of organosilane self-assembled monolayers on glass or silicon. First, poly(etheretherketone) surface act...
Source: Journal of Bioactive and Compatible Polymers - April 20, 2015 Category: Research Authors: Zheng, Y., Xiong, C., Wang, Z., Zhang, L. Tags: Original Articles Source Type: research

MC3T3-E1 preosteoblast cell-mediated mineralization of hydroxyapatite by poly-dopamine-functionalized graphene oxide
We report a biomimetic mineralization of hydroxyapatite induced by poly-dopamine-functionalized reduced graphene oxide (RGO-PDA). Graphene oxide was first simultaneously reduced and surface functionalized by one-step oxidative polymerization of dopamine. The resultant RGO-PDA was further used as a bioinspired surface to mimic the mineralization of hydroxyapatite during bone formation. MC3T3-E1 cells were cultured on the RGO-PDA substrates to observe various cellular activities and hydroxyapatite mineralization. The MC3T3-E1 cells on RGO-PDA substrates show higher cellular activities such as proliferation, adhesion, and ost...
Source: Journal of Bioactive and Compatible Polymers - April 20, 2015 Category: Research Authors: Cheng, J., Liu, H., Zhao, B., Shen, R., Liu, D., Hong, J., Wei, H., Xi, P., Chen, F., Bai, D. Tags: Original Articles Source Type: research

Hoechst 33258-conjugated hyaluronated fullerene for efficient photodynamic tumor therapy and necrotic tumor targeting
In this study, we synthesized a Hoechst 33258–conjugated hyaluronated fullerene consisting of Hoechst 33258 (as a target moiety to detect necrotic tumor cells), hyaluronic acid (as a target polymer to bind the CD44 receptor overexpressed on the surface of tumor cells), and fullerene (as a photosensitizing agent). This conjugate self-assembled to form nanoparticles consisting of a hydrophilic block (Hoechst 33258 and hyaluronic acid) and a lipophilic block (fullerene). We utilized these nanoparticles to improve the antitumor efficacy via photodynamic tumor therapy. The HCT-116 cells that were damaged after the first p...
Source: Journal of Bioactive and Compatible Polymers - April 20, 2015 Category: Research Authors: Kim, S., Park, J., Youn, Y. S., Oh, K. T., Bae, J. H., Lee, E. S. Tags: Original Articles Source Type: research

Surface grafting of chitosan shell, polycaprolactone core fiber meshes to confer bioactivity
In this study, hydrophilic meshes displaying primary amine groups were prepared by coaxially electrospinning fibers with a chitosan/poly(ethylene oxide) shell and a polycaprolactone core. These chitosan–polycaprolactone fiber meshes were mechanically robust (Young’s modulus of 10.1 ± 1.6 MPa under aqueous conditions) with tensile properties comparable to polycaprolactone fiber meshes. Next, the integrin adhesion peptide arginine–glycine–aspartic acid was grafted to chitosan–polycaprolactone fiber meshes. Cell culture studies using bone marrow stromal cells indicated significantly better...
Source: Journal of Bioactive and Compatible Polymers - April 20, 2015 Category: Research Authors: Vaidya, P., Grove, T., Edgar, K. J., Goldstein, A. S. Tags: Original Articles Source Type: research

Microwave-assisted synthesis of carboxymethyl psyllium and its development as semi-interpenetrating network with poly(acrylamide) for gastric delivery
In this study, microwave-induced synthesis of carboxymethyl psyllium is reported. The carboxymethyl psyllium was characterized by Fourier transform infrared, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and proton nuclear magnetic resonance spectroscopic analysis. It also showed fair antibacterial activity against model bacteria Escherichia coli, thus confirming its bioactivity. Its semi-interpenetrating polymer network hydrogels with poly(acrylamide) were synthesized and investigated for their swelling behavior in simulating gastric fluid at 37°C. The swelling ratio strongly depended on...
Source: Journal of Bioactive and Compatible Polymers - April 20, 2015 Category: Research Authors: Bajpai, S. K., Chand, N., Agrawal, A. Tags: Original Articles Source Type: research

Healing effect of a fibrin-based scaffold loaded with platelet lysate in full-thickness skin wounds
In this study, a bio-synthetic scaffold composed of poly(ether)urethane–polydimethylsiloxane material and fibrin was developed for platelet lysate delivery to chronic skin wounds. The kinetics release and the bioactivity of growth factors released from platelet lysate–loaded poly(ether)urethane–polydimethylsiloxane–fibrin scaffold were investigated, respectively, by enzyme-linked immunosorbent assay and a cell proliferation test using human fibroblasts. The in vitro experiments demonstrated that the platelet lysate–loaded poly(ether)urethane–polydimethylsiloxane–fibrin scaffold pro...
Source: Journal of Bioactive and Compatible Polymers - February 18, 2015 Category: Research Authors: Losi, P., Briganti, E., Sanguinetti, E., Burchielli, S., Al Kayal, T., Soldani, G. Tags: Original Articles Source Type: research

Biodegradability, cellular compatibility and cell infiltration of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in comparison with poly({varepsilon}-caprolactone) and poly(lactide-co-glycolide)
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate), poly(-caprolactone), and poly(1actide-co-glycolide) films were prepared by solution casting and electrospinning. The degradability of cast films was evaluated in vitro and in vivo by recording the weight remaining, observing the morphology, and measuring change in molecular weight and M w/M n polydispersity. In addition, cell proliferation on electrospun films was tested by MTT assay, and cell infiltration into electrospun films was assessed through subcutaneous implantation in rats. By analyzing data obtained from these tests, we discovered that...
Source: Journal of Bioactive and Compatible Polymers - February 18, 2015 Category: Research Authors: An, J., Wang, K., Chen, S., Kong, M., Teng, Y., Wang, L., Song, C., Kong, D., Wang, S. Tags: Original Articles Source Type: research

Effect of rat bone marrow derived-stem cell delivery from serum-loaded oxidized alginate-gelatin-biphasic calcium phosphate hydrogel for bone tissue regeneration using a nude mouse critical-sized calvarial defect model
Blood serum contains various kinds of proteins which are necessary for tissue repair and regeneration process. Defect healing of fractured bone is initiated by the influx of blood and then clot formation. Thus, proteins in serum may have the ability to stimulate the bone regeneration process. In this work, we investigated the fabrication of serum-loaded oxidized alginate–gelatin–biphasic calcium phosphate hydrogels with various contents of blood serum (0%, 5%, 10%, and 15% in % v/v) to evaluate the stimulatory effect of serum proteins on bone regeneration. This system was also evaluated for rat bone marrow&ndas...
Source: Journal of Bioactive and Compatible Polymers - February 18, 2015 Category: Research Authors: Paul, K., Linh, N. T. B., Kim, B.-r., Sarkar, S. K., Choi, H.-J., Bae, S.-H., Min, Y.-K., Lee, B.-T. Tags: Original Articles Source Type: research

Bi-layered PLCL/(PLGA/{beta}-TCP) composite scaffold for osteochondral tissue engineering
In this study, an osteochondral composite scaffold was fabricated by combining a sintering method and a gel pressing method with poly(lactide-co-glycolide), beta-tricalcium phosphate, and poly(lactide-co-caprolactone). The composite scaffold constituted a poly(lactide-co-glycolide)/beta-tricalcium phosphate scaffold, which has osteoconduction activity for bone regeneration, and an elastic poly(lactide-co-caprolactone) scaffold, which has mechano-active properties for cartilage regeneration. To examine mechanical and biological properties, tensile tests, porosimetry, electron microscopy, and in vitro and in vivo experiments...
Source: Journal of Bioactive and Compatible Polymers - February 18, 2015 Category: Research Authors: Kim, S. H., Kim, S. H., Jung, Y. Tags: Original Articles Source Type: research

Microenvironmental changes in collagen/polyvinyl alcohol blends in the presence of ionic liquid: A spectroscopic analysis
This study describes the microenvironmental changes due to various non-covalent interactions occurring in collagen/polyvinyl alcohol blends in the presence of ionic liquid, 1-butyl-3-methylimidazolium chloride, using spectroscopic techniques. These non-covalent interactions alter the hydration network of collagen. Electronic spectral analysis of collagen/polyvinyl alcohol/ionic liquid blends exhibited movement of tyrosine amino acid from the hydrophilic to hydrophobic core of collagen. Conformational studies investigating the influence of 1-butyl-3-methylimidazolium chloride on the intramolecular H-bonds revealed increased...
Source: Journal of Bioactive and Compatible Polymers - February 18, 2015 Category: Research Authors: Mehta, A., Kanungo, I., Rao, J. R., Fathima, N. N. Tags: Original Articles Source Type: research