Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70 w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28 days.

Source: Journal of Bioactive and Compatible Polymers - February 15, 2016 Category: Research Authors: Ickowicz, D. E., Abtew, E., Khan, W., Golovanevski, L., Steinman, N., Weiniger, C. F., Domb, A. J. Tags: Original Articles Source Type: research