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Cervical cytopathological changes in Pap smear test in the city of Santa Cruz do Sul, Rio Grande do Sul, Brazil
Conclusion: The benign cellular alterations were the most frequent, with the prevalence of inflammation. The most common precursor lesions of cervical cancer were ASC-US and LSIL.RESUMEN Objetivo: Determinar los cambios citol ógicos en mujeres que se hicieron la prueba de Papanicolaou por el sistema público de salud [Sistema Ú;nico de Saúde (SUS)] en un laboratorio de la ciudad de Santa Cruz do Sul, Rio Grande do Sul, Brasil. Métodos: Los datos fueron recogidos de informes citológicos del año de 2015 por el Siste ma de Información de Cáncer. Se eligieron las variables edad y alteración citológica. El análisis...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - August 2, 2019 Category: Pathology Source Type: research

Study of specimen stability in clinical laboratories: ensuring quality of results and patients' safety
(Source: Jornal Brasileiro de Patologia e Medicina Laboratorial)
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - August 2, 2019 Category: Pathology Source Type: research

Molecular analysis of translocations associated with Ewing sarcoma: case report
We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigatio...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Fetal anencephaly with umbilical cord attached to cerebrovasculosa area: autopsy report
ABSTRACT Our aim was to report the unusual case of an anencephalic fetus that was born with the umbilical cord attached to its cephalic pole. The patient was a 16-year-old pregnant woman. Ultrasound evaluation at 17 weeks revealed a single fetus without cranial vault and brain parenchyma, compatible with anencephaly. Postnatal evaluation, through an autopsy, was consistent with this diagnosis. Moreover, it was observed that the umbilical cord was attached to the area cerebrovasculosa and there was the presence of a fibrous tissue, suggestive of an amniotic band. We have found only one similar case described in the literatu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Bronchogenic cyst in an unusual location
This article reports the case of a patient with lingual bronchogenic cyst and presents a brief review of discrepancies in the nomenclature of lingual cysts. A 2-year-old male patient was admitted to the pediatric surgery outpatient clinic of a university hospital due to the presence of a 2 cm mass on the dorsal surface of the tongue. The tumor was excised and the anatomopathological report revealed a foregut cyst, bronchogenic subtype. Lingual cysts are rare, especially when compatible with bronchogenic formations. Their pathogenic process is not clear; one of the possibilities is the separation of cells from the primitive...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Peripheral odontogenic fibroma in the mandibular gingiva: case report
This article reports the case of a 29-year-old woman who presented with a painless, reddish mass in the right vestibular mandibular gingiva between the second premolar and the first molar. Radiographic examination revealed small crestal bone loss in the region. Microscopic analysis revealed a tumor composed of cellular fibroblastic connective tissue intermingled with conspicuous islands and strands of apparently inactive odontogenic epithelium. The final diagnosis was POF. No clinical signs of recurrence were observed 22 months after surgical excision. POF may be clinically mistaken for other common gingival lesions, such ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Hyperuricemia in Down syndrome children and adolescents
Conclusion: We found a high rate of hyperuricemia in children with DS that equally affects both genders, except in the age range of 13-15 years, in which it was more common among females.RESUMEN Introducci ón: Pacientes con síndrome de Down (SD) perecen tener mayor grado de hiperuricemia, aunque hay pocos estudios que traten esa cuestión. Niveles elevados de ácido úrico (AU) son un factor de riesgo independiente para enfermedad cardiovascular aterosclerótica. Objetivo: Estudiar la prevalencia d e hiperuricemia en niños y adolescentes con SD y su distribución de acuerdo a la edad. Métodos: Estudio retrospectivo ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Polymorphisms in the IL17A gene are not involved in the development of preeclampsia in the Brazilian population
Conclusion: There is no association between the allele frequencies, genotype, inheritance models and haplotypes of the rs4711998 A>G, rs8193036 C>T and rs2275913 A>G polymorphisms of the IL17A gene and PE.RESUMEN Introducci ón: La preeclampsia (PE) se define como hipertensión arterial asociada a proteinuria después de la semana 20 de gestación en mujeres anteriormente normotensas. La interleucina 17ª (IL17A) es un inductor potente de inflamación tisular y polimorfismos del gen IL17A pueden modular la expresión g énica y afectar las funciones de las células Th17, aumentando la susceptibilidad a la PE. Ob...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

A quantitative enzyme-linked immunosorbent assay (ELISA) for the detection of anti-double-stranded DNA IgG antibodies
Conclusion: ELISA showed excellent results in terms of sensitivity and specificity, with a potential use in research and routine diagnostics.RESUMEN Introducci ón: La detección de anticuerpos contra el ácido desoxirribonucleico (ADN) de doble cadena (dc) es uno de los criterios de clasificación para el diagnóstico de lupus eritematoso sistémico (LES). Objetivo: Describir una técnica inmunoenzimática (ELISA) cuantitativa para detección de anticuer pos de inmunoglobulina de clase G (IgG) anti-ADNdc. Métodos: Se evaluó el desempeño de la técnica ELISA mediante el test inmunofluorescencia indirecta con Crithidi...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Oral cavity lipoma: a study of 101 cases in a Brazilian population
Conclusion: Lipomas are uncommon lesions in the oral cavity, which present a higher prevalence in the buccal mucosa of adults, aged between 50 and 70 years, and with higher female preference.RESUMEN Introducci ón: Lipomas son tumores benignos del tejido blando comúnmente encontrados en el cuerpo humano. Aunque comunes en la región de la cabeza y cuello, son raros en la cavidad oral, representando solo del 1% al 4% de las lesiones benignas en esa cavidad. Objetivo: El presente estudio pretende identifi car las características clínicas e histopatológicas de lipomas de la cavidad oral; los materiales recolectados fuer...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Cytomorphological analysis of cervical cytological smears of women aged over 60 years
Conclusion: The absence of SCJ indicates a diagnostic limitation of sample collection. Although the frequency of lesions has been similar to other studies, and the recommended age range for the examination is between 25 and 60 years, it is important to note that many women older than this range should perform the collection of oncology cytology due to existence of elderly women with risk profile for the disease.RESUMEN Introducci ón: La atrofia cervicovaginal es una condición que puede afectar a las mujeres después de la menopausia, y la citología es una herramienta diagnóstica útil en esos casos. Objetivo: Evaluar...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Anti-Leptospira spp. antibodies in meat dealers in Tunja, Boyacá, Colombia
The objective of this study was to determine the serological prevalence of anti-Leptospira antibodies in meat dealers in the city of Tunja, Boyac á, Colombia. An observational, cross-sectional and descriptive study was carried out in a population of 186 operators from meat establishments in the city of Tunja. The samples were analyzed using the microagglutination test in order to determine the serovar that causes the infection. Each particip ant answer a survey with important questions about socio-demographic, epidemiological and occupational factors. A seroprevalence of 43% [n = 80; 95% confidence interval (CI): 36%-50%]...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 23, 2019 Category: Pathology Source Type: research

Solitary fibrous tumor of the kidney: a report of two cases
We present two cases of 40- and 48-year-old males, one with incidental detection of a peripheral mass; another with hilar lesion perceived following investigation of hematuria. Both revealed a spindle-cell proliferation, without mitosis and necrosis. Immunohistochemical studies: positivity for CD34, CD99 and B-cell lymphoma 2 (Bcl-2). No sign of disease were evident nine and five months after surgery, respectively. SFT is mostly benign, but can show malignant behavior. Morphologic and immunohistochemical characteristics are essential for diagnosis.RESUMEN Tumor fibroso solitario (TFS) es una neoplasia mesenquimal infrecuen...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research

Glomus tumor in the abdominal wall
We report a case of a 45-year-old male patient who presented with a painful mass in the abdominal wall. The patient underwent total tumor resection and the anatomical pathology diagnosis was of glomus tumor. The glomus tumor presents differential diagnosis of carcinoid tumor, hemangiopericytoma and vascular leiomyoma.RESUMEN El tumor gl ómico es un tumor raro y benigno de tejidos blandos. Se presenta el caso de un paciente de 45 anos, con el hallazgo de un nódulo doloroso en la pared abdominal. Se realizó una resección completa de la lesión y el diagnóstico por anatomia patológica fue de tumor glómico. El diagnóst...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research

Fetal death: obstetric, placental and fetal necroscopic factors
Conclusion: Among the causes of fetal death, ascending infection was the most prevalent; the maternal death related to pregnancy were the ones that stood out the most.RESUMEN Introducci ón: Muerte fetal se define como muerte del producto de la concepción independientemente de la duración del embarazo. Objetivos: El objetivo de este trabajo fue investigar los factores de riesgo maternos (obstétricos y placentarios) y los hallazgos de la autopsia asociados a muerte fetal con bas e en los datos obtenidos en el Servicio de Verificación de Muerte [Serviço de Verificação de óbitos (SVO)] de Florianópolis, Santa Catar...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research