Jornal Brasileiro de Patologia e Medicina Laboratorial 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Clinical and laboratory repercussions in patient with hemoglobin SD-Punjab disease: a case report
We report the first case of hemoglobin SD-Punjab disease, a rare form of sickle-cell disease, in the state of Bahia. Detection was possible by a test for the identification of hemoglobin (Hb) variants with the high-resolution liquid chromatography technique. By means of the molecular study of chromosomal polymorphism with beta-globin S gene, the Bantu haplotype was observed. According to studies, there is strong association between the prevalence of Bantu haplotype and reduced levels of fetal Hb and Hb D-Punjab as a stimulating factor for S polymerization, what contributes to the hematological disorders of the disease and ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 18, 2017 Category: Pathology Source Type: research
Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction
This article discusses the differences between troponin fragments immunoreactivity to the development of cTnI determination tests, such as the high-sensitivity tests, which arise with the proposal of guaranteeing greater efficiency in the AMI associated diagnosis.RESUMO Entre as doen ças cardiovasculares (DCV), o infarto agudo do miocárdio (IAM) atualmente é considerado a causa mais comum de morte e incapacidade em todo o mundo. Vários testes laboratoriais vêm sendo desenvolvidos para a detecção de lesões cardíacas, entre eles, as troponinas, consideradas marcador (biom arcador sugestivo) padrão-ouro de lesão mi...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 18, 2017 Category: Pathology Source Type: research
Frequency of classes I and II HLA alleles in deceased donors of solid organs in Espírito Santo, Brazil
Conclusion: The present study contributed with significant information about the frequency of HLA antigens in deceased donors of solid organs in the Brazilian population that will contribute to optimize t he transplantation process in the country.RESUMO Introdu ção: A população brasileira possui grande mistura racial, tendo sido originada, principalmente, de caucasoides de origem europeia, africanos e índios. As especificidades do sistema de antígenos leucocitários humanos (HLA) variam entre os diferentes grupos populacionais e étnicos, uma vez que demonstram maior similaridade entre populações com origem comum...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 18, 2017 Category: Pathology Source Type: research
Evaluation of VITEK 2 Compact and VITEK MS in the identification of coagulase-negative staphylococci isolated from blood cultures
Conclusion: Through the analysis between the two devices and based on scientific articles comparing the methods involved in the study, it was possible to observe the great biochemic al similarity among the coagulase-negative staphylococci species, this being the main limitation of the phenotypic method. The VITEK MS equipment showed high discrimination between species when compared to the gold standard method, besides being rapid and easy to use.RESUMO Introdu ção: Estafilococos coagulase-negativos (ECN) estão entre os principais colonizantes de pele e mucosas, atuando como comensais. Apesar de apresentarem baixa virul...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 18, 2017 Category: Pathology Source Type: research
High-sensitivity troponins: a major breakthrough
(Source: Jornal Brasileiro de Patologia e Medicina Laboratorial)
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 18, 2017 Category: Pathology Source Type: research
Comparison of cythopathology and frozen section methods in the intraoperative evaluation of breast sentinel lymph node
Conclusion: The results of the present study shows that both CP and FS are reliable techniques for metastasis detection in breast sentinel lymph nodes, and are equivalent in sensibility, specificity, accuracy, PPV and NPV.RESUMO Introdu ção: A análise citopatológica (CP) e o método de corte por congelação (CC) são técnicas disponíveis de avaliação intraoperatória do linfonodo sentinela nas cirurgias para tratamento de câncer de mama que vão definir a necessidade de linfadenectomia axilar. Objetivo: Comparar a avalia ção CP e os CCs de linfonodos sentinela axilares na pesquisa de metástases em pacientes ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Lymphoepithelial cyst on the tongue: case report at unusual location
ABSTRACT Oral lymphoepithelial cyst (OLEC) is an uncommon lesion that develops in oral lymphoid tissue. The aim of the present study was to report a clinical case of OLEC in the tongue. A 22-year-old patient presented a nodular lesion, yellowish, with a softened consistency, measuring 0.5 cm in the ventral surface of the tongue. Under the clinical hypotheses of mucocele and OLEC, excisional biopsy was performed. The histopathological examination revealed a cystic lesion covered by a parakeratinized stratified squamous epithelium, which presented in its fibrous capsule a prominent lymphoid tissue. Based on the definitive di...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Perforation of pyometra presenting as obstructive acute abdomen and peritonitis: a case report
We report a rare case of a 67-year-old postmenopausal woman presenting diffuse peritonitis secondary to spontaneous perforation of pyometra with obstructive acute abdomen. During laparotomy was performed subtotal abdominal hysterectomy with bilateral salpingo-oophorectomy. The histopathology found the presence of moderately differentiated uterine squamous cell carcinoma. Despite intensive care, the patient died due to multiple organ failure resulting from sepsis on postoperative day 1. This case shows the importance of clinical suspicion on the acute gynecological diseases presenting as a systemic disease in the emergency ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Tissue microarray: physical and chemical parameters involved in the construction of recipient blocks
Conclusion: The data obtained from the physical and chemical adjustments of the TMA recipient blocks provided vital information that, w hen applied in TMA research projects, may reduce the losses associated with the method.RESUMO Introdu ção: O microarranjo tecidual (MAT) é considerado um método inovador em vários campos, com uma vasta diversidade de aplicações e vantagens em relação às técnicas histomorfométricas clássicas. A vantagem mais importante que o MAT oferece é a avaliação simultânea de um grande número d e espécimes de uma fonte limitada de material. Contudo, ele apresenta uma taxa elevada de...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Evaluation of the fetal urine sample through vesicocentesis: an approach to diagnostic and therapeutic application
We report the case of a fetus with mega-bladder and suspected lower urinary tract obstruction (LUTO). The 20-week pregnancy ultrasound scan showed absence of amniotic fluid (anhydramnios), enlarged bladder, and narrowing of the urethra in the proximal region. At 21 weeks of gestational age, vesicocentesis was performed for relief of obstruction and analysis of biochemical of the fetal urine and karyotyping was carried out, which presented normal result (46,XY). This technique is indicated in cases of severe oligohydramnios or difficulty of placental access and has diagnostic and therapeutic function.RESUMO Relatamos o caso...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Clinical and laboratory diagnosis of Zika fever: an update
ABSTRACT Zika fever can be defined as an acute febrile viral illness, mainly transmitted by the mosquito of the genus Aedes. It makes a differential diagnosis from diseases caused by other flaviviruses, such as chikungunya and dengue fever. Many people with Zika virus (ZIKV) infection will not have symptoms or will only have mild clinical symptoms. The clinical conditions are nonspecific and characterized by low-grade fever, pruritic erythematous maculopapular rash, non-purulent conjunctival hyperemia without pruritus, arthralgia, myalgia, and headache. It is a benign, self-limiting and short-duration condition. Complicati...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Effect of multiple freeze-thaw cycles on the stability of positive anti-treponemal serum samples
Conclusion: It was shown that 174 freeze-thaw cycles of anti-treponemal sera did not affect the stability and the quality of samples, when evaluated by chemiluminescence assay.RESUMO Introdu ção: As amostras biológicas têm sido utilizadas em múltiplas investigações por um longo período de tempo, e existe a preocupação a respeito dos seus repetidos ciclos de congelamento e descongelamento que podem afetar os resultados de determinado ensaio imunodiagnóstico pela ocorrência de dano físico do anticorpo de interesse. Objetivo: O objetivo deste estudo foi investigar o impacto dos sucessivos ciclos de congelament...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Prevalence and antimicrobial susceptibility profile of ESKAPE pathogens from the Federal District, Brazil
Conclusion: Studies such as this should be performed periodically in order to evaluate the bacterial susceptibility profile. They demonstrate the importance of implementing strategies to prevent hospital-acquired infections, as well as greater antibiotic prescribing control.RESUMO Introdu ção: Os principais patógenos causadores de infecções nosocomiais foram resumidos pela sigla ESKAPE, que são as iniciais das seguintes bactérias: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa e Enterobacter spp., as quais pos suem altas taxas de resistência por c...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Repetition of biochemistry tests in a laboratory of public hospital in southwest of Bahia, Brazil, and associated cost
Conclusion: It was observed that most of the repetitions performed in the laboratory were classified as unnecessary when evaluated by the criteria used. These repetitions generated a potentially avoidable laboratory cost increase, negatively impacting the time to release the results.RESUMO Introdu ção: A repetição de exames é uma prática antiga comum aos laboratórios clínicos, usada basicamente para confirmação de resultados. No entanto, ao conhecer a história dos pacientes, as repetições tornam-se evitáveis. Elas prejudicam o tempo de liberação de resultados, aumentam consumo de insumos e geram custo aos...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
Hereditary hemochromatosis: study of laboratory alterations related to polymorphism
Conclusion: According to the study, it was possible to observe a significant elevated serum ferritin level in all HH genotypes.RESUMO Introdu ção: A hemocromatose hereditária (HH) é uma doença hereditária associada ao armazenamento em excesso de ferro. Sua forte presença é subestimada por ser assintomática nos pacientes. Na cidade de Caxias do Sul (RS), por conta da maior frequência da doença, é necessário realizar um estudo que relaciona os genótipos HH com as análises laboratoriais. Objetivo: Avaliar a associação dos polimorfismos C282Y, H63D e S65C e dos indicadores laboratoriais dos casos estudados. ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 28, 2017 Category: Pathology Source Type: research
