Jornal Brasileiro de Patologia e Medicina Laboratorial This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions
In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions (p< 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis.RESUMEN El ant ígeno leucocitario humano G (HLA-G) es una molécula no clásica del complejo principal de histocompatibilidad que ha s...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Performance analysis of commercial rapid tests for serum troponin detection
Conclusion: The kits from Abon®, Interteck®, Medtest® and Wama® showed excellent diagnostic performance, what makes them an importa nt diagnostic tool in smaller laboratories without automated equipment.RESUMEN Introducci ón: Hoy en día, las pruebas rápidas representan importante herramienta diagnóstica, ofrecen resultados en corto espacio de tempo y dispensan el uso de equipos automatizados. Objetivo: Evaluar el desempeño de cinco kits de pruebas rápidas para detectar troponina I en suero. Material y método s: Se eligieron 100 especímenes de pacientes sospechosos de infarto agudo de miocardio (IAM) de un ho...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Performance evaluation of HIV infection diagnostic tests
Conclusion: The data of this study corroborate the importance of adopting effective management tools to ensure quality of HIV infection diagnosis.RESUMEN Introducci ón: Muchos factores pueden impactar en el desempeño pruebas para diagnóstico de la infección por el virus de la inmunodeficiencia humana (VIH), comprometiendo los resultados de investigaciones poblacionales. Objetivo: El objetivo de este estudio fue evaluar el desempeño de pruebas rápidas (PR ) en el punto de atención utilizadas para diagnosticar el VIH en relación con las pruebas convencionales en muestras de sangre de la población de travestis y mu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Ductal carcinoma in situ of the breast: correlation of architectural, cytological, IHC findings and recurrence analysis
Conclusion: We observed a greater relationship of ER with the low nuclear grade, while Ki-67 was related to the high-grade. DCIS presented a higher nuclear grade compared to ICNST. The less common pure pattern was the micropapillary, and the most common, the solid. Comedonecrosis was more frequent in the solid pattern. Our results showed that high-grade was more common in the solid and comedo subtype, and low-grade was more frequent in the cribriform.RESUMEN Objetivo: Este estudio evalu ó las características del carcinoma ductal in situ (CDIS), incluyendo grado citológico, patrón arquitectural y inmunohistoquímica ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Evaluation of PSA requests in men under 40 years of age
Conclusion: There is a very high frequency of PSA requests in men with low probability of benefiting from the test. It is necessary to invest in the dissemination of best practices related to prostate cancer screening, especially among clinicians and cardiologists.RESUMEN Objetivos: Evaluar la cantidad de solicitudes del ant ígeno prostático específico (PSA) para hombres menores de 40 años, así como observar la posible influencia de la especialidad del médico solicitante. Material y método: Estudio observacional, de corte transversal, que utilizó la base de datos de un gran laboratorio clínico brasileño con ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Progesterone and estradiol receptors and Ki-67 in the superficial and deep infiltrating endometriosis
Conclusion: It is possible to infer that other factors are involved in the response to hormonal variations for super fi cial and deep endometriosis.RESUMEN Introducci ón: Endometriosis es una enfermedad dependiente de hormonas que se caracteriza por la presencia ectópica de tejido endometrial sensible a los esteroides del ovario. El estrógeno y la progesterona son los principales reguladores del tejido endometrial, y la expresión de receptores de esas hormon as en el tejido ectópico parece tener conexión con la fi siopatolog ía de la enfermedad. El Ki-67 es un marcador de proliferación tisular y de la cinétic...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Multi-categorical classification using deep learning applied to the diagnosis of gastric cancer
Conclusion: The results show the potential application of convolutional neural networks for digitized slides of gastric cancer, in accordance with international literature findings.RESUMEN Introducci ón: Los patólogos enfrentan actualmente un aumento sustancial de su trabajo diagnóstico en diferentes tipos de cáncer. Eso ocurre debido al incremento de la incidencia y de la detección de neoplasias, además de la subespecialización diagnóstica y del advenimiento de la medicina personalizad a. Hay numerosos tratamientos disponibles para diferentes tipos de cáncer, y el diagnóstico debe ser realizado con celeridad ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Association of the CHGA gene polymorphism in patients with hemorrhagic stroke and/or aneurysm
Conclusion: The Glu264Asp CHGA polymorphism does not seem to contribute to the genesis of the CHGA protein expression in this patients group, but to understand whether or not there is a possible association of the pathology in question and whether the mutation will contribute in the gene therapy and thus to improve patients ’ quality of life.RESUMEN Introducci ón: Enfermedades cerebrovasculares han sido vinculadas a diversos genes. La cromogranina A (CgA) es utilizada como un marcador en enfermedades cardiovasculares. Por consiguiente, evaluar el polimorfismo y verificar la asociación con esa patología es muy impo...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Comparison of micronuclei frequency between smokers and non-smokers: a systematic review
Discussion and conclusion: Individuals who use tobacco present genotoxic and cytotoxic damages that interfere in the mitosis process, which leads to MN formation. The hypothesis of smoking as the cause of this genetic alteration is corroborated by the authors when comparing the data obtained in their studies between risk groups and control groups.RESUMEN Introducci ón: El cáncer es el resultado de la acumulación de diversas modificaciones en el material genético, por lo tanto, es posible realizar su detección citogenética usando biomarcadores. Micronúcleos (MN) se han abordado por la literatura como biomarcadores d...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Thrombogram: case report of pseudothrombocytopenia
ABSTRACT The thrombogram is one of the components of the blood count that includes platelet quantification and evaluation. The presence of laboratory artifacts, such as incorrect platelet counts by autoanalyzers, can lead to pseudothrombocytopenia, which is responsible for 15% to 30% of the cases of isolated thrombocytopenia observed in laboratory routine. Pseudothrombocytopenia induced by the anticoagulant ethylenediaminetetraacetic acid (EDTA) is one of the most frequent cases in which the presence of anticoagulant in blood samples can cause platelet aggregation or platelet satellitism. Careful observation of the data em...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 17, 2020 Category: Pathology Source Type: research

Leg myxoid liposarcoma: correlation between image and anatomopathological tests
ABSTRACT A 41-year-old male patient refers to a painful tumor on the lateral side of the right leg. Ultrasonography visualized a predominantly hypoechoic well-delineated large heterogeneous mass in the subcutaneous tissue, showing an internal hyperechoic area. Magnetic resonance imaging (MRI) demonstrated an oval and lobulated tumor with well-defined margins at the anterolateral part of the leg, with contrast enhancement. The anatomopathological evaluation revealed a neoplasm with an extensive chondromyxoid matrix. The immunohistochemical study demonstrated positive vimentin (V9 clone), positive S-100 protein and negative ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 17, 2020 Category: Pathology Source Type: research

Benign neural lesions of the oral and maxillofacial complex: a 48-year-retrospective study
Conclusion: The data obtained confirmed that lesions of neural origin are uncommon in the oral cavity and that neurofibroma is the most frequent, female are the most affected, and the tongue is the most prevalent affected area.RESUMEN Introducci ón: Las lesiones nerviosas periféricas son algunas de las varias enfermedades que pueden afectar el tejido nervioso. Esas lesiones de origen neural pueden ocurrir en la región maxilofacial, aunque sean raras. Objetivo: El objetivo de este estudio fue evaluar retrospectivamente el perfil de paci entes con tumores neurales benignos del complejo oral y maxilofacial y realizar co...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 17, 2020 Category: Pathology Source Type: research

The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative.RESUMEN Introducci ón: La colpocitología y la investigación del ácido desoxirribonucleico (ADN) del virus del papiloma humano (VPH) de alto riesgo son herramientas bien conocidas para la detección de lesiones cervicales, puesto que permiten el diagnóstico precoz del cáncer y sus lesiones precursoras. Objetivo: El objetivo de este estudio es evaluar la capacidad de detección del ADN-VPH de alto riesgo por capt...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 17, 2020 Category: Pathology Source Type: research

Sociodemographic and clinicopathological profile of 80 cases of oral squamous cell carcinoma
Conclusion: The profile of OSCC patients in Nova Friburgo partly reflects the world literature, with emphasis on the following differences: low average number of mitoses found in the histopathological analysis and prevalence of well-differentiated lesions. Su ch differences may be a result of the characteristic variations of the local population, reinforcing the importance of conducting epidemiological studies that demonstrate OSCC peculiarities in different regions.RESUMEN Objetivo: Trazar el perfil sociodemogr áfico y clínico de los casos de biopsia incisional de carcinoma oral de células escamosas (COCE) recogidos e...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 17, 2020 Category: Pathology Source Type: research

Quantitative and qualitative evaluation of IgG synthesis in 8,947 cerebrospinal fluid samples
Conclusion: We showed a strong association between OCB and other CSF inflammatory parameters. The presence of cases with increased quantitative CSF IgG synthesis without OCB suggests that both quantitative and qualitative methods should be performed in the evaluation of neuroinflammatory processes.RESUMEN Introducci ón: El incremento de la síntesis intratecal de inmunoglobulina G (IgG) puede ser encontrado en diferentes enfermedades neuroinflamatorias. Objetivo: Analizar retrospectivamente diferentes métodos de evaluación de la producción intratecal. Métodos: Se examinaron datos del líquido cefalorraqu ídeo (LCR...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 17, 2020 Category: Pathology Source Type: research