Survey for bacterial testing of platelet components in Latin America
ConclusionsScreening practices and mitigation strategies vary considerably between sites highlighting the need for standardisation of procedures in Latin America. (Source: ISBT Science Series)
Source: ISBT Science Series - February 1, 2017 Category: Hematology Authors: S. Ramirez ‐Arcos, C. P. McDonald, R. J. Benjamin, Tags: Working Party Publications Source Type: research
Distribution of HNA alleles in Brazilians
(Source: ISBT Science Series)
Source: ISBT Science Series - February 1, 2017 Category: Hematology Authors: E. Moritz, L. B. Lopes, J. O. Bordin Tags: Letter to the Editor Source Type: research
Approaches to assessing and minimizing blood wastage in the hospital and blood supply chain
Despite the scale of blood usage worldwide, blood remains a scarce and precious resource. As with any perishable product, careful management of inventories to minimize wastage is crucial. However, due to the nature of the supply of blood, wastage is not only an economic issue as every unit wasted, squanders the time and effort of the human donor. Blood inventory management is therefore a trade‐off, ensuring 100% availability of all blood products at all times whilst minimizing wastage. Hospitals are at the front line of blood use and are the location where much blood is wasted. Inventory management practices in hospital ...
Source: ISBT Science Series - January 26, 2017 Category: Hematology Authors: N. Yates, S. Stanger, R. Wilding, S. Cotton Tags: Congress Review Source Type: research
Report on the 18th Platelet Immunology Workshop of the ISBT 2016
ConclusionsThis workshop has identified three specific areas in platelet serology with need for improvement: methodology amendment to reduce non‐specific binding and cross‐reactivity; standardization of antibody quantification (such as anti‐HPA‐1a); and detection of anti‐HPA‐15 antibodies. The use of universal monoclonal antibodies for antigen capture assays as well exactly defined references of well‐defined specificity and concentration should be envisioned. (Source: ISBT Science Series)
Source: ISBT Science Series - January 26, 2017 Category: Hematology Authors: A. Wikman, A. M örtberg, U. J. Sachs, S. Santoso Tags: Working Party Publications Source Type: research
Keys to move to self ‐sufficiency in safe blood components based on voluntary blood donation
One of the oldest resolutions of WHO urges member states to promote the blood services based on voluntary non‐remunerated blood donation (VNRBD). Consequently, achieving self‐sufficiency in six driver products has been focused on by the WHO and other international agencies in 2010. However, both VNRBD and self‐sufficiency are not a reality in many countries. In this article, proposed ways to achieve self‐sufficiency in blood products and plasma‐derived medicines are discussed. The main proposed ways included are as follows: (i) Donor management: attention to public awareness, donors’ expectations, selection cri...
Source: ISBT Science Series - January 26, 2017 Category: Hematology Authors: M. Maghsudlu Tags: Congress Review Source Type: research
Haematological aspects of bleeding emergencies – a brief overview
Bleeding emergencies can be encountered in many clinical settings. While there are some key common principles, a focussed targeted approach is also needed for optimum patient outcome depending on the scenario, for example trauma, obstetric, acute gastrointestinal. Coherent multidisciplinary management with explicitly clear communication in particular between clinical and laboratory teams is essential. Major haemorrhage protocols developed in consensus between key teams and based on national guidelines where available will help support management in these clinically fraught situations. Important lessons can be learnt with r...
Source: ISBT Science Series - January 24, 2017 Category: Hematology Authors: S. Allard, P. H. B. Bolton ‐Maggs Tags: Original Paper Source Type: research
Table of Contents
(Source: ISBT Science Series)
Source: ISBT Science Series - December 21, 2016 Category: Hematology Tags: Issue Information Source Type: research
Title Page
(Source: ISBT Science Series)
Source: ISBT Science Series - December 21, 2016 Category: Hematology Tags: Issue Information Source Type: research
Customizing anticoagulation strategies during leukapheresis to limit citrate exposure
ConclusionCustomization of the inlet:AC ratio while maintaining a constant, stable inlet flow rate is effective in limiting citrate exposure during leukapheresis. (Source: ISBT Science Series)
Source: ISBT Science Series - December 14, 2016 Category: Hematology Authors: J. L. McMannes, J. Hershberger, D. M. Parker, S. De Reys, T. Loos, P. Hematti Tags: Original Article Source Type: research
Cost ‐effectiveness of implementing molecular immunohematology
ConclusionMolecular immunohematology is not the implementation of cost reductions but the recognition of ‘effective’ processes and algorithms that incorporate molecular testing to provide tangible benefits to pregnant women and transfusion recipients. (Source: ISBT Science Series)
Source: ISBT Science Series - December 13, 2016 Category: Hematology Authors: G. A. Denomme Tags: Congress Review Source Type: research
Prevention of transfusion ‐transmitted Zika virus in French Polynesia, nucleic acid testing versus pathogen inactivation
ConclusionNucleic acid testing and PI were used in FP to prevent ZIKV TTIs. NAT was an effective measure once implemented but is not a proactive solution. PI is a proactive solution but with only systems approved for platelets and plasma. Based on the FP experience, there is an urgent need for approved whole blood and/or red blood cell PI systems and to develop multiplex NAT to maintain the availability of the blood supply in remote areas during arbovirus epidemics. (Source: ISBT Science Series)
Source: ISBT Science Series - December 13, 2016 Category: Hematology Authors: D. Musso, J. Broult, D. Bierlaire, M. C. Lanteri, M. Aubry Tags: Invited Review Source Type: research
Arbovirus epidemics and blood safety in Brazil
Brazil has experienced successive outbreaks of dengue in the last three decades, with more than one million cases per year since 2014, as vector control has proven unsuccessful. In 2014, Chikungunya and Zika viruses were introduced to Brazil in different sites. Currently, all three agents are spread all over the country, posing a considerable burden to the health system. Transfusion‐transmitted cases of CHKV have never been reported while for Dengue, there are globally less than ten well‐documented clusters and recently two cases of TT ZIKV were published, both from Brazil. It is recognized that thousands of units from...
Source: ISBT Science Series - December 13, 2016 Category: Hematology Authors: J. E. Levi Tags: Invited Review Source Type: research
Methodological challenges in observational transfusion research: lessons learned from the Scandinavian Donations and Transfusions (SCANDAT) database
ConclusionWhile observational research in the transfusion medicine field has great potential for improving transfusion safety, pitfalls are plentiful and easy to overlook. In this review, we have gone over some methodological issues that we feel are especially important to consider for researchers who are involved in this type of research. (Source: ISBT Science Series)
Source: ISBT Science Series - December 13, 2016 Category: Hematology Authors: G. Edgren, K. Rostgaard, H. Hjalgrim Tags: Original Paper Source Type: research
Managing haemovigilance at hospital and national level
ConclusionHaemovigilance should be part of quality management systems of blood centres and healthcare institutions and should result in improved policies, procedures and practices in the blood transfusion chain. (Source: ISBT Science Series)
Source: ISBT Science Series - December 13, 2016 Category: Hematology Authors: S. Hindawi Tags: Congress Review Source Type: research
Role of red blood cells in haemostasis and thrombosis
In contrast to an obsolete notion that erythrocytes, or red blood cells (RBCs), play a passive and minor role in haemostasis and thrombosis, over the past decades there has been increasing evidence that RBCs have biologically and clinically important functions in blood clotting and its disorders. This review summarizes the main mechanisms that underlie the involvement of RBCs in haemostasis and thrombosis in vivo, such as rheological effects on blood viscosity and platelet margination, aggregation and deformability of RBCs; direct adhesion and indirect biochemical interactions with endothelial cells and platelets. The abil...
Source: ISBT Science Series - December 13, 2016 Category: Hematology Authors: R. I. Litvinov, J. W. Weisel Tags: Congress Review Source Type: research
