Host inflammatory response to mosquito bites enhances the severity of arbovirus infection
In this study, we identified key aspects of mosquito bite inflammation that are important determinants of the subsequent systemic course and clinical outcome of infection. As such, host responses to mosquito saliva may prove to be a predictor of subsequent disease severity and consequently could also be useful in risk‐stratifying blood products. (Source: ISBT Science Series)
Source: ISBT Science Series - September 4, 2017 Category: Hematology Authors: C.S. McKimmie, M. Pingen, S.R. Bryden, D.A. Lefteri Tags: Congress Review Source Type: research
Blood components – so much more than clots and oxygen delivery!
Abstract
Blood, and the blood components, packed red blood cells (pRBC), platelet concentrate (PC), plasma and cryoprecipitate, have traditionally been transfused to maintain or improve oxygen delivery, blood volume and/or haemostatic capacity. There is, however, emerging evidence that blood components may support other alternative functions beyond oxygen delivery, blood volume and haemostasis. Thus, PC may through their functions as innate immunological effector cells improve immune competence. Plasma may through its endothelial protective and repairing functions improve vascular integrity and hence outcome in critical il...
Source: ISBT Science Series - September 4, 2017 Category: Hematology Authors: S. R. Ostrowski Tags: Congress Review Source Type: research
Auditing as a means of detecting waste
Abstract
There can be numerous sources of waste in the transfusion service. The most obvious source is wastage of the blood products themselves, either by expiration on the shelf of the blood bank, or else after they have been issued to a patient location in the hospital but not used and not returned to the blood bank in time to be returned into the general inventory. Reducing expiration due to the former mechanism is the sole responsibility of the transfusion service – to make sure that its inventory is commensurate with the volume of transfusions performed at the hospital(s) that it serves. Audits of clinical practice,...
Source: ISBT Science Series - September 4, 2017 Category: Hematology Authors: M. H. Yazer Tags: Congress Review Source Type: research
Alloimmunisation and nephropathy in sickle cell disease patients in Jeddah, Saudi Arabia
ConclusionDespite the ethnic diversity of our donor population, the prevalence of alloimmunisation is comparable to previous reports. Alloimmunisation was associated with severe proteinuria, a marker of SCD nephropathy. Prospective research is needed to further characterise factors associated with risk of alloimmunisation in SCD in Saudi Arabia. (Source: ISBT Science Series)
Source: ISBT Science Series - August 24, 2017 Category: Hematology Authors: S. Adam, M. Badawi Tags: Original Paper Source Type: research
Monitoring near ‐miss events in a hospital blood bank
ConclusionMonitoring of near‐miss events helped us in identifying the processes that can be improved and taking appropriate measures to enhance transfusion safety. (Source: ISBT Science Series)
Source: ISBT Science Series - August 24, 2017 Category: Hematology Authors: F. Karim, M. Ali, A. Rashid, M. S. Shaikh, M. Karim, B. Moiz Tags: Original Paper Source Type: research
Who returns and becomes a regular blood donor? Analysis of a donor database in Fukushima, Japan
ConclusionsClub members were characterised by higher numbers of previous donations and a preference for component donations. Young people and women were less likely to be returning donors. Directed efforts to recruit and retain donors considering their donation sites and health status are recommended to ensure a stable blood supply now and in the future. (Source: ISBT Science Series)
Source: ISBT Science Series - August 24, 2017 Category: Hematology Authors: M. Kashimura, A. Goto, K. E. Nollet, H. Ohto, S. Yasumura, K. Konno Tags: Original Paper Source Type: research
Issue Information
(Source: ISBT Science Series)
Source: ISBT Science Series - August 24, 2017 Category: Hematology Tags: Issue Information Source Type: research
Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies
ISBT Science Series,Volume 13, Issue 1, Page 105-111, February 2018. (Source: ISBT Science Series)
Source: ISBT Science Series - August 18, 2017 Category: Hematology Source Type: research
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ISBT Science Series,Volume 13, Issue 1, Page 105-111, February 2018. (Source: ISBT Science Series)
Source: ISBT Science Series - August 18, 2017 Category: Hematology Source Type: research
Lessons learned from Paris and Nice
This article covers the impacts of the attacks on immunohaematology and delivery activities as well as the actions that were implemented to ensure sufficient blood supply. Then, the impacts on blood component production are set out. EFS integrated organization and available stocks allowed meeting blood requirements and enabled a strong control of outdating, after unprecedented blood collections during the weeks following 13 November 2015. Lastly, the article presents EFS experience feedback of Paris attacks and of the event that occurred in Nice on 14 July 2016, which helped improve our crisis management pattern with:
S...
Source: ISBT Science Series - August 1, 2017 Category: Hematology Authors: S. No ël, A. François, F. Le Failler, F. Charpentier, T. Baudonnet, P. Bierling, R. Djoudi, F. Pirenne, S. Killic, D. Benomar, J.‐B. Corby, C. Fabra, C. Nicoué, M. Collet, N. Brosius, O. Briat, R. Spinardi, J. Chiaroni, V. David, F. Toujas Tags: Congress Review Source Type: research
Red cell apheresis: pros and cons
The collection of red blood cells (RBC) by apheresis, first developed in the 1970's for therapeutic use, for many years was not considered suitable for obtaining blood components for transfusion because of concerns on donor safety and elevated costs compared to whole blood (WB) donation. Single‐dose RBC apheresis as a part of multicomponent collections and double‐dose RBC (2RBC) apheresis for autologous and allogeneic transfusions were approved by the FDA between 1995 and 1997, and in Europe starting from 2000. The widespread implementation of these procedures followed mainly to address blood supply issues, as large nu...
Source: ISBT Science Series - August 1, 2017 Category: Hematology Authors: L. Infanti Tags: Congress Review Source Type: research
Cold stored platelets in treatment of bleeding
The success of whole blood transfusion in military operational settings has engaged a debate on reintroduction of cold‐stored whole blood in treatment of critical bleeding in civilian health care. The haemostatic function of platelets stored cold at 4°C has however been questioned. In this review, we discuss the effects of cold storage on platelets, whether stored in whole blood or as platelet concentrates. Cold storage of platelets was abandoned during the 1970s due to reduced circulation time. Haemostatic superiority of cold‐stored platelets was however suggested. In vitro studies show reduced risk of bacterial cont...
Source: ISBT Science Series - August 1, 2017 Category: Hematology Authors: T. O. Apelseth, A. P. Cap, P. C. Spinella, T. Hervig, G. Strandenes Tags: Congress Review Source Type: research
Managing a rare donor programme: the immunohaematology laboratory perspective
Alloimmunization is a major complication of blood transfusion which occurs more frequently in patients who are chronically transfused. It causes serologic investigations and makes the selection of compatible blood difficult, expensive and time‐consuming. Prompt availability of compatible units for patients with complex alloimmunization requires access to an inventory of extensively typed blood and to a database of rare donors. There are two key factors for rare donor provision. First, the routine programmes of red cell antigen typing in large cohorts of donors. Second, the ability to enrol healthy donors and patients neg...
Source: ISBT Science Series - August 1, 2017 Category: Hematology Authors: C. Paccapelo Tags: Congress Review Source Type: research
Donor fainting: risks factors and prevention strategies
Identifying risk factors as well implementing preventive strategies with regard to fainting or prefainting reactions associated with whole blood donation are important issues for donor safety and retention. To assess fainting risk factors, two retrospective case–control studies of severe immediate and delayed fainting reactions were performed based on the French hemovigilance data collected from 2011 to 2013 and involving close to 9 000 000 donors. In a multivariate analysis, immediate fainting was strongly associated with first‐time donation and young donor age, while delayed fainting was associated with a female ge...
Source: ISBT Science Series - August 1, 2017 Category: Hematology Authors: P. Tiberghien, C. Morand, S. Gross, J. ‐L. Bosson, A.‐M. Fillet Tags: Congress Review Source Type: research
The validation and implementation of donor screening for hepatitis B virus, hepatitis C virus, human immunodeficiency virus 1/2 and syphilis by ultrio elite assay (Panther system) and chemiluminescence assay (Abbott Architect i2000SR system) in Namibia
Infectious disease screening of Namibia blood donations for infectious diseases was contracted to the South African National Blood Service (SANBS) since 2004 and needed to be relocated back to Namibia. A cost analysis conducted showed that by introducing certain strategies, it was cost‐effective to implement ID‐NAT in Namibia. NAMBTS chose Ultrio Elite assay/Panther System (Gen‐Probe and Novartis, USA) for ID‐NAT for HIV 1/2 RNA, HBV DNA and HCV RNA and Chemiluminescent immunoassay done on the Architect i2000SR system (Abbott, Delkenheim, Germany) for HIV 1/2 Ag/Ab, anti‐HCV, HBsAg and Syphilis. For performance e...
Source: ISBT Science Series - August 1, 2017 Category: Hematology Authors: I. Chipare, H. T. Charuma, B. von Finckenstein, C. J. Gouws Tags: Congress Review Source Type: research
