Cardiac Metabolism in a Pig Model of Ischemia–Reperfusion by Cardiac Magnetic Resonance with Hyperpolarized 13C-Pyruvate
Conclusions 13C-pyruvate MRI is able to detect transient changes in regional metabolism in an in-vivo model of myocardial ischemia–reperfusion. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - February 5, 2015 Category: Endocrinology Source Type: research
Cardiac Metabolism in a Pig Model of Ischemia-Reperfusion by Cardiac Magnetic Resonance with Hyperpolarized 13C-Pyruvate
Conclusions 13C-pyruvate MRI is able to detect transient changes in regional metabolism in an in-vivo model of myocardial ischemia-reperfusion. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 20, 2015 Category: Endocrinology Source Type: research
Impact of low-grade albuminuria on left ventricular diastolic dysfunction
Conclusions A high UACR level that is still below the current microalbuminuria threshold is significantly associated with an increased prevalence of LV diastolic dysfunction in CAD patients. Our data suggest that low-grade albuminuria in high-risk populations may provide greater cardiovascular risk stratification. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 19, 2015 Category: Endocrinology Source Type: research
Psoriasis and cardiovascular risk: Immune-mediated crosstalk between metabolic, vascular and autoimmune inflammation
Publication date: Available online 10 January 2015 Source:IJC Metabolic & Endocrine Author(s): R.A. Kölliker Frers , R.J. Bisoendial , S.F. Montoya , E. Kerzkerg , R. Castilla , P.P. Tak , J. Milei , F. Capani Introduction and Background In the last few years, a substantial body of evidence indicates that cutaneous psoriasis and psoriatic arthritis patients are at higher risk of developing cardiovascular disease. However, underlaying mechanism remains no completed understood. In this review we discuss the role of the immune system in the development of atherosclerosis, focusing on available data implic...
Source: IJC Metabolic and Endocrine - January 10, 2015 Category: Endocrinology Source Type: research
New evidences about the strict relationship between the epicardial fat and the aerobic exercise
Conclusion This study confirms that lifestyle, and in particular aerobic exercise, plays a fundamental role in the cardiovascular risk prevention. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 10, 2015 Category: Endocrinology Source Type: research
Post-operative aspartate aminotransferase levels independently predict mortality after isolated coronary artery bypass grafting
Conclusion AST levels within 48hours after CABG independently predict mortality and morbidity but not the latter, were adjusted for hsTnT. Although AST rise is not specific to myocardial necrosis, it remains useful for prognosis in cardiac surgery. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 10, 2015 Category: Endocrinology Source Type: research
High-density lipoprotein cholesterol and left atrial or left atrial appendage thrombus in non-valvular atrial fibrillation patients
Publication date: Available online 9 January 2015 Source:IJC Metabolic & Endocrine Author(s): Lijun Cui , Liju Han , Zhao Li , Junwei Ma , Xianghong Ma , Changyu Zhou , Guangping Li (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 9, 2015 Category: Endocrinology Source Type: research
A Circulating Biomarker Risk-Prediction Model Correlates with CHADS-2 Risk Score in Chronic Atrial Fibrillation
Conclusions A biomarker risk-model using a combination of hs-CRP and DROMs correlates well with CHADS-2 risk scores in chronic AF. Either or both of these markers may add predictive power to future stroke risk prediction models. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 9, 2015 Category: Endocrinology Source Type: research
Resistance to antiplatelet drugs. Can it be assessed?
Publication date: Available online 8 January 2015 Source:IJC Metabolic & Endocrine Author(s): Rossella Marcucci High platelet reactivity (HPR) during dual antiplatelet therapy is a marker of vascular risk, in particular stent thrombosis in patients with acute coronary syndromes. Genetic determinants (CYP2C19*2 polymorphism), advanced age, female gender, diabetes and reduced ventricular function are related to a higher risk to develop HPR. In addition, inflammation and increased platelet turn-over, as revealed by the elevated percentage of reticulate platelets in patients’ blood that characterize the acute ph...
Source: IJC Metabolic and Endocrine - January 8, 2015 Category: Endocrinology Source Type: research
The role of aldosterone receptor blocker therapy in hypertension and heart failure
Publication date: Available online 13 December 2014 Source:IJC Metabolic & Endocrine Author(s): Giuseppina Santese , Cosimo Stefanio , Gianluca Belletti , Maria Boiani , Antonietta Schipani , Rosanna Trane , Fabio Zacà The aldosterone receptor blocker therapy as an “add-on” to hypotensive therapy is an excellent therapeutic strategy that has proved to be particularly effective in treating refractory hypertension, hypertension with organ damage and overweight hypertensive patients. Aldosterone receptor blockers are extremely useful in inhibiting hormonal activation linked with heart failure: they hav...
Source: IJC Metabolic and Endocrine - December 13, 2014 Category: Endocrinology Source Type: research
Metabolomics in Atherosclerosis
Publication date: Available online 3 December 2014 Source:IJC Metabolic & Endocrine Author(s): Demir Djekic , Rachel Nicoll , Mehmed Novo , Michael Henein It is well established that atherosclerotic cardiovascular disease (ACD) is a leading cause of death in the West. There are several predisposing factors for ACD, which can be divided into two groups: firstly modifiable risk factors, including hypertension, dyslipidaemia, type 2 diabetes mellitus, obesity, smoking and a sedentary lifestyle and secondly the unmodifiable risk factors such as age, gender and heredity. Since single biomarkers are unable to pro...
Source: IJC Metabolic and Endocrine - December 3, 2014 Category: Endocrinology Source Type: research
Proteomics analysis reveals IGFBP2 as a candidate diagnostic biomarker for heart failure
Conclusion IGFBP2 is a new biomarker to diagnose HF which could be used to provide additional information to the NPs. Animals models will help in the evaluation of the putative IGFBP2 regulated mechanisms in HF. Clinical Trial Registration ClinicalTrials.gov NCT01024049. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - December 3, 2014 Category: Endocrinology Source Type: research
A long-term echocardiographic study of the course of valvular dysfunctions following discontinuation of ergot-derived dopamine agonists in patients with Parkinson’s disease
Conclusions This long-term study confirm an improvement of the restrictive VHD after withdrawal of EDA in PD patients. However, only a partial reversibility of cardiac valvular abnormalities was observed. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - December 3, 2014 Category: Endocrinology Source Type: research
Heart failure: a difficult case of diagnostic definition
We describe the case of a 58year old man, who had recently undergone a coronary angioplasty with implantation of DES on the proximal circumflex branch and MO1 proximal for a NSTEMI, who had come to the emergency department complaining of severe pain in the back radiating in the precordial region. A few days later he developed a framework of acute heart failure with severe left ventricular dysfunction, accompanied by fever and blood cultures positive for Staphylococcus aureus. Instrumental examinations showed a massive coronary pseudoaneurysm originating from the circumflex branch ostium, which led to compressive action aga...
Source: IJC Metabolic and Endocrine - November 29, 2014 Category: Endocrinology Source Type: research
Nutraceuticals and cholesterol-lowering action
Publication date: Available online 22 November 2014 Source:IJC Metabolic & Endocrine Author(s): Arrigo F.G. Cicero , Angelo Parini , Martina Rosticci Nutraceuticals play an important role in cardiovascular prevention in patients with dyslipidemia. Many scientific studies support use of these substances alone or associated with other drugs in clinical practice. Specifically, monacolines, berberine, policosanol and gamma-oryzanol could significantly reduce cholesterolemia. However, there is still an insufficient number of studies demonstrating morbility and morbidity outcomes of nutraceuticals, nor are suffici...
Source: IJC Metabolic and Endocrine - November 22, 2014 Category: Endocrinology Source Type: research
