Diabetes, hypertension, overweight and hyperlipidemia and 7-day case-fatality in first myocardial infarction
Conclusions In this population-based inception cohort study, diabetes but not hypertension and hyperlipidemia were associated with MI fatality. This further emphasizes the importance of diabetes as a cardiovascular risk factor and the need for close surveillance of diabetic patients. Overweight was however associated with decreased MI fatality. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - June 4, 2016 Category: Endocrinology Source Type: research
Aging impairs ischemia-induced neovascularization by attenuating the mobilization of bone marrow-derived angiogenic cells
Conclusions The age-related impairment in ischemia-induced neovascularization is largely attributable to a marked attenuation of BMDAC mobilization with a preservation of intrinsic angiogenic function with age. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 26, 2016 Category: Endocrinology Source Type: research
The relationship between skeletal muscle and ventilatory response to exercise in myocardial infarction
Conclusions The increase in skeletal muscle index was associated with the amelioration of ventilatory efficacy to exercise at the peak level. Furthermore, the increase in skeletal muscle index may account for favorable prognosis. These findings could strengthen the role of skeletal muscle in exercise capacity of patients with myocardial infarction. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 25, 2016 Category: Endocrinology Source Type: research
Soluble urokinase plasminogen activator receptor (suPAR): Its relation to neurological outcome in patients with survived cardiac arrest
Conclusions SuPAR serum levels in patients with poor neurological outcome were significantly higher as compared to patients with good neurological outcome. However, the prognostic value was low and inadequate because of a substantial overlap of serum suPAR levels between the outcome groups. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 20, 2016 Category: Endocrinology Source Type: research
Cardiovascular risk assessment using LOX-index and Self-Rating Depression Scale
Conclusions LOX-Index appears to be a comprehensive marker that could evaluate the status of multiple CVD risk factors. The classification with LOX-Index and SDS could contribute to the risk assessment for CVD. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 18, 2016 Category: Endocrinology Source Type: research
From bench to bedside: Chronic inflammation and cardiovascular risks
Publication date: September 2016 Source:IJC Metabolic & Endocrine, Volume 12 Author(s): Angel López-Candales, David Harris (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 17, 2016 Category: Endocrinology Source Type: research
Relationship between breast arterial calcification and lipid profile, plasma atherogenic index, Castelli's risk index and atherogenic coefficient in premenopausal women
Conclusion BAC is a valuable tool for the prediction of deranged lipid profile. Dyslipidemia, PAI, AC, CRI-I and CRI-II are risk factors for the development of atherosclerosis. Our results indicate that BAC is potentially useful tool for the detection of dyslipidemia and early atherosclerosis in premenopausal women. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 10, 2016 Category: Endocrinology Source Type: research
Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients
Publication date: June 2016 Source:IJC Metabolic & Endocrine, Volume 11 Author(s): Kaido Paapstel, Jaak Kals, Jaan Eha, Kaspar Tootsi, Aigar Ottas, Anneli Piir, Mihkel Zilmer (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 8, 2016 Category: Endocrinology Source Type: research
Deteriorated clinical outcome in coronary artery disease patients with a high prevalence of Porphyromonas gingivalis infection
Conclusions P. gingivalis was identified by sensitive detection in patients with CAD, diagnosed by coronary CTA. P. gingivalis in oral saliva can be a potential marker which is associated with clinical outcomes in patients with CAD. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 7, 2016 Category: Endocrinology Source Type: research
Posttraumatic stress disorder symptoms and hypercoagulability during emergency department evaluation for acute coronary syndrome
Publication date: June 2016 Source:IJC Metabolic & Endocrine, Volume 11 Author(s): Vy Thuy Ho, Daichi Shimbo, Joan Duer-Hefele, William Whang, Melinda Chang, Donald Edmondson (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - May 7, 2016 Category: Endocrinology Source Type: research
The combination of nutraceutical and simvastatin enhances the effect of simvastatin alone in normalising lipid profile without side effects in patients with ischemic heart disease
Conclusions The association of a nutraceutical and simvastatin 20mg may be a valid therapeutic option for the treatment of hyperlipidemia in patients with ischemic heart disease intolerant to statin at high doses, in the absence of side effects. Further studies are needed to clarify the mechanisms of action of nutraceuticals. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - March 18, 2016 Category: Endocrinology Source Type: research
N-terminal-pro-brain natriuretic peptide elevations in the course of septic and non-septic shock reflect systolic left ventricular dysfunction assessed by transpulmonary thermodilution
Conclusions In septic and non-septic shock, NT-proBNP elevations reflect systolic left ventricular dysfunction and are associated with a poor outcome. They may help recognition of cardiac dysfunction in shock and its management when invasive hemodynamic monitoring is not yet instituted. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 17, 2016 Category: Endocrinology Source Type: research
The response of NT-proBNP to intensified medication in advanced chronic heart failure
Conclusion Excessively high NT-proBNP levels in HF patients correlated with cardiac, renal and laboratory parameters. After successful HF treatment, NT-proBNP levels were halved, irrespective of their baseline levels. The precise role and underlying mechanism of NT-proBNP warrant further study. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - January 13, 2016 Category: Endocrinology Source Type: research
The autocrine role of tryptase in pressure overload-induced mast cell activation, chymase release and cardiac fibrosis
Conclusion The results indicate the presence of PAR-2 on MCs and that tryptase inhibition and nedocromil prevented TAC-induced fibrosis and increases in MC density, activation, and chymase release. Tryptase also significantly increased chymase concentration in ventricular tissue culture media, which was prevented by the tryptase inhibitor. Hydroxyproline concentration in culture media was significantly increased with tryptase incubation as compared to the control group and the tryptase group incubated with nafamostat mesilate or chymostatin. We conclude that tryptase contributes to TAC-induced cardiac fibrosis primarily vi...
Source: IJC Metabolic and Endocrine - November 25, 2015 Category: Endocrinology Source Type: research
Immunological markers of frailty predict outcomes beyond current risk scores in aortic stenosis following transcatheter aortic valve replacement: Role of neopterin and tryptophan
Conclusions Increased immune activation and associated tryptophan degradation serve as hallmarks of frailty underscoring the prognostic role of baseline inflammation for outcome in patients with severe aortic stenosis undergoing TAVR, and thus may provide a future therapeuthic target in this elderly patient population. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 25, 2015 Category: Endocrinology Source Type: research
