Effect of combination of ezetimibe and a statin on coronary plaque regression in patients with acute coronary syndrome ZEUS trial (eZEtimibe Ultrasound Study)
Conclusions Additional LDL-C reduction with combination therapy tended to reduce more plaque regression compared to a statin alone in patients with ACS. In diabetic patients, further reduction of LDL-C was associated with a significantly greater reduction in PV. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Microvascular inflammation in atherosclerosis
Publication date: June 2014 Source:IJC Metabolic & Endocrine, Volume 3 Author(s): Laura Vitiello , Ilaria Spoletini , Stefania Gorini , Laura Pontecorvo , Davide Ferrari , Elisabetta Ferraro , Eugenio Stabile , Massimiliano Caprio , Andrea la Sala Atherogenesis is the pathogenetic process leading to formation of the atheroma lesion. It is associated to a chronic inflammatory state initially stimulated by an aberrant accumulation of lipid molecules beyond the endothelial barrier. This event triggers a cascade of deleterious events mainly through immune cell stimulation with the consequent liberation of ...
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Cardiac manifestations of myasthenia gravis: A systematic review
Conclusion Heart muscle is a target for autoimmune inflammation in myasthenia gravis. Advancing age, thymoma, and anti-Kv1 antibodies appeared to be risk factors. Symptom overlap with myasthenia may result in failure to recognize cardiac involvement. Prospective studies are needed to establish causal link with striational antibodies and to make screening recommendations for cardiac involvement. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Design, methods, baseline characteristics and interim results of the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study
Conclusions The CASABLANCA study will examine the role of novel biomarkers and metabolomics for predicting a wide range of cardiovascular, neurologic, and renal complications in patients undergoing angiography. Full results are expected in the latter half of 2014 (Clinical Trials.Gov # NCT00842868). (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Impact of serum bilirubin levels on carotid atherosclerosis in patients with coronary artery disease
Conclusion We demonstrated that low serum bilirubin levels were associated with severe carotid atherosclerosis in CAD patients. Our data suggest that serum bilirubin levels might be an independent, useful, and cost-effective tool for evaluating atherosclerotic status in CAD patients. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Coronary microvascular dysfunction in overt diabetic cardiomyopathy
Conclusion In patients with DM2 myocardial perfusion reserve is markedly decreased, suggestive of microvascular disease. In this small cohort MPRI impairment did not correlate to the LV EF deterioration. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
On the interference of sildenafil on platelet aggregation: An ex vivo pilot study
Publication date: September 2014 Source:IJC Metabolic & Endocrine, Volume 4 Author(s): Lucrezia Gambardella , Pasquale Lista , Simona Pichini , Roberta Pacifici , Walter Malorni , Elisabetta Straface (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Vascular injury is improved by pre-meal glulisine-based bolus insulin therapy in type 2 diabetic patients
Publication date: September 2014 Source:IJC Metabolic & Endocrine, Volume 4 Author(s): Junya Ashihara , Katsuyuki Yanagisawa , Shinji Obara , Norio Wada , Yuri Nishino , Ayako Ojima , Takanori Matsui , Kei Fukami , Sho-ichi Yamagishi (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Cardiometabolic implication of sarcopenia: The Korea National Health and Nutrition Examination Study (KNHANES) 2008–2010
Conclusions Sarcopenia, defined by the ASM/wt index, but not by ASM/ht2, was significantly associated with an increased risk of cardiometabolic disorders in Korean adults. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Impact of the serum bone-specific alkaline phosphatase level at the initiation of hemodialysis therapy for end-stage renal disease on cardiovascular events
Conclusions The serum BAP level at the initiation of HD therapy for ESRD is a useful non-invasive biomarker for predicting CV events. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Does renal function influence the prognostic impact of type 2 diabetes mellitus in patients with chronic heart failure and left ventricular dysfunction?
Conclusions In patients with CHF and reduced LVEF the prognostic impact of T2DM depends on the degree of renal dysfunction. Its contribution in all-cause mortality risk prediction is limited to mild–moderate renal dysfunction subgroup, while prognostic power is lost in normal renal function and in severe renal dysfunction patients. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Effect of statins on the serum soluble form of receptor for advanced glycation end-products and its association with coronary atherosclerosis in patients with angina pectoris
Conclusions Statin therapy increased serum sRAGE levels, and this increase was associated with negative vessel remodeling and atheroma regression in the coronary artery. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
The increasing impact of a higher body mass index on the decrease in plasma B-type natriuretic peptide levels
Conclusions BMI is a significant factor that reduces the plasma BNP level. This impact is significantly increased in patients with a high BMI, even among those with a worsening severity of heart failure. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Cardiovascular risk factors among the inhabitants of an urban Congolese community: results of the VITARAA Study
Conclusion Our findings highlight the staggering rates of cardiovascular risk factors in sub-Saharan Africa and underscore the pressing need to move their prevention and control higher on the political agenda. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
Endothelial dysfunction is associated with occult coronary artery disease detected by positron emission tomography
Conclusions: Endothelial dysfunction is independently associated with silent ischemia and this association is not confounded by genetic or other shared familial factors. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 1, 2014 Category: Endocrinology Source Type: research
