Psoriasis and cardiovascular risk: Immune-mediated crosstalk between metabolic, vascular and autoimmune inflammation

Publication date: Available online 10 January 2015 Source:IJC Metabolic & Endocrine Author(s): R.A. Kölliker Frers , R.J. Bisoendial , S.F. Montoya , E. Kerzkerg , R. Castilla , P.P. Tak , J. Milei , F. Capani Introduction and Background In the last few years, a substantial body of evidence indicates that cutaneous psoriasis and psoriatic arthritis patients are at higher risk of developing cardiovascular disease. However, underlaying mechanism remains no completed understood. In this review we discuss the role of the immune system in the development of atherosclerosis, focusing on available data implicating the role of an enhanced immune-mediated pro-inflammatory status in psoriasis and psoriatic arthritis diseases. Methods A systematic search was performed on Pubmed until November 2014, with preference to the sources published within the past 8 years, including epidemiological studies (prospective and retrospective); cross-sectional case-control studies and reviews. . Articles were selected according critical associations using the following keywords: arthritis, immune mediated inflammatory diseases, psoriasis. These were combined with close related keywords reflecting cardiovascular diseases: atherogenesis, endothelial dysfunction, intima media thickness, subclinical atherosclerosis, plaque, thrombosis, thrombus, fibrinolysis, coagulation, and reactive oxygen species. Both type of diseases selected terms were separately combined with nontraditional (i...
Source: IJC Metabolic and Endocrine - Category: Endocrinology Source Type: research