Table of Contents
(Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Source Type: research
Editorial board
(Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Source Type: research
In This Issue
(Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Source Type: research
Poor Prognostic Impact of FGF4 Amplification in Patients with Esophageal Squamous Cell Carcinoma
In the present study, we aimed to determine the prognostic impact and clinicopathological feature of FGF4 amplification in patients with esophageal squamous cell carcinoma (ESCC). Fluorescence in situ hybridization (FISH) with FGF4 probe was analyzed using tissue microarray consisting of representative cores of 267 ESCC cases. FGF4 amplification was observed in 52.8% (141/267) of patients. Patients with FGF4 amplification showed a significantly shorter disease free survival (DFS) or disease-specific overall survival (OS) compared with those without FGF4 amplification (both P (Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Authors: Jie Huang, Qi Song, Hao Wang, Haixing Wang, Chen Xu, Xin Wang, Zhengzeng Jiang, Yanqiu Wang, Yifan Xu, Jieakesu Su, Haiying Zeng, Lijie Tan, Hongguang Zhu, Dongxian Jiang, Yingyong Hou Tags: Original Contributions Source Type: research
Expansile invasive growth pattern is definite evidence for the diagnosis of small hepatocellular carcinomas: a comparative study of 37 cases
In this study, we reviewed 1025 cases of HCC and examined for the histologic characteristics of small hepatocellular carcinomas, to facilitate more accurate diagnosis. Slides of archived HCC cases were reviewed by two senior pathologists and small HCC were identified according to the canonical criteria. (Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Authors: Qiongrong Chen, Manxiang Wang, Mingwei Wang, Su Jin, Shu-yuan Xiao, Sufang Tian Tags: Original Contributions Source Type: research
SASH1, a potential therapeutic target for cancer —reply
We have read the letter to the editor “SASH1, a potential therapeutic target for cancer” written by Qianqian Wang. We are honored that our manuscript attracts attention in such a short time [1]. Just as emerging studies have demonstrated, SASH1 is a candidate for tumor suppression in multiple cancers. Due to structural features, SAS H1 participates in the regulation of various signaling pathways. Sun et al. [2] found that overexpression of SASH1 diminished the phosphorylation of PI3K and Akt, and thus inhibited thyroid cancer cell proliferation and invasion. (Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Authors: Nan Zhou Tags: Correspondence Source Type: research
Does ezrin play a predictive role in cancer patients undergoing radiotherapy and/or chemotherapy?
Dear Editor, (Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Authors: Yasemin Benderli Cihan Tags: Correspondence Source Type: research
Utility of STAT 6 and 13q14 deletion in the classification of the benign spindle cell stromal tumors of the breast
The boundaries of the benign spindle cell stromal tumors of the breast are still confusing. This is the reason why different names are interchangeably used for the same tumor and vice versa the same name for different tumors. Therefore we studied the immunoexpression of easily available markers, such as CD34, alpha-smooth muscle actin, desmin, with the addition of STAT6, as well as the chromosome 13q14 region by fluorescence in situ hybridization analysis in a series of 19 cases of benign spindle cell stromal tumors of the breast. (Source: Human Pathology)
Source: Human Pathology - June 22, 2018 Category: Pathology Authors: Gaetano Magro, Giuseppe Angelico, Alberto Righi, Stefania Bonini, Lucia Salvatorelli, Juan Palazzo Tags: Original Contributions Source Type: research
SASH1, a potential therapeutic target for cancer
We read with interest the paper by Zhou et al. [1], reporting that downregulated SASH1 expression indicated poor clinical prognosis in gastric cancer. Xie et al. [2] also found that downregulation of SASH1 correlated with poor prognosis in cervical cancer. Chen et al. [3] investigated the effects of the SASH1 gene in A549 human lung cancer cells and found that SASH1 may inhibit A549 cell growth and proliferation. Similarly, the overexpression of SASH1 may also be related to the decreased migration of A549 human lung cancer cells. (Source: Human Pathology)
Source: Human Pathology - June 21, 2018 Category: Pathology Authors: Qianqian Wang, Hongfeng Dai Tags: Correspondence Source Type: research
Clinicopathological correlation of PD-L1 expression in primary and metastatic breast Cancer and infiltrating immune cells
In this study we correlated differential expression of PD-L1 in breast cancer (BC) and its microenvironment from a cohort of patients with BC, paired locally metastatic disease to regional lymph nodes (LN) and non-paired distantly metastatic disease (mets). PD-L1 expression was correlated with several pathologic and clinical parameters in tumor and tumor immune cells (ICs) (CD3, CD4, CD8, CD20 and CD68) using the Ventana antibody (SP263) in 41BC, 46 paired mets in LNs and 46 distant mets. (Source: Human Pathology)
Source: Human Pathology - June 21, 2018 Category: Pathology Authors: Ossama Tawfik, Bruce F. Kimler, Tejashree Karnik, Peter Shehata Tags: Original Contributions Source Type: research
Clinicopathological significance of PSF3 expression in uterine endometrial carcinomas
PSF3 (Partner of SLD Five 3) is a member of the heterotetrameric complex termed GINS. Previous studies have shown that PSF3 is up-regulated in several cancers and is associated with tumor malignancy. However, the clinicopathological significance of PSF3 expression in endometrial lesions is still poorly understood. To investigate whether PSF3 could serve as a useful biomarker for endometrial carcinomas, we performed immunohistochemical analysis of PSF3 expression. In 155 cases of endometrial carcinomas (ECs), the mean tumor proportion score (TPS) of PSF3 expression was 30.7% in G1 endometrioid carcinoma, 55.0% in G2 endomet...
Source: Human Pathology - June 21, 2018 Category: Pathology Authors: Jong Kun Park, Noriyuki Otsuka, Utano Tomaru, Hiroaki Suzuki, Manabu Azuma, Kazuhira Okamoto, Katsushige Yamashiro, Masanori Kasahara Tags: Original Contributions Source Type: research
Tumor budding is associated with poor prognosis of oral squamous cell carcinoma and histologically represents an epithelial –mesenchymal transition process
In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial –mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor budding status was reviewed using archived hematoxylin and eosin-stained slides. In addition, the expression of EMT regulators was evaluated by immunohistochemistry using antibodies against Snail and Twist. (Source: Human Pathology)
Source: Human Pathology - June 21, 2018 Category: Pathology Authors: Kyoung-Ok Hong, Kyu-Young Oh, Wui-Jung Shin, Hye-Jung Yoon, Jae-Il Lee, Seong-Doo Hong Tags: Original contribution Source Type: research
Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma
Synovial sarcoma (SS) is a highly aggressive malignant soft tissue sarcoma with typical characteristics of both epithelial and mesenchymal differentiation. Matrix metalloproteinase-14 (MMP-14) is reported to play an important role in some of these tumors. It induces epithelial-to-mesenchymal transition (EMT) in some carcinomas, such as breast and prostate cancers. However, the role of MMP-14 in the pathogenesis of SS remains unclear. Therefore, we investigated the role of MMP-14 and EMT/mesenchymal-to-epithelial transition (MET) in SS. (Source: Human Pathology)
Source: Human Pathology - June 20, 2018 Category: Pathology Authors: Manli Liu, Yan Qi, Lili Zhao, Dongdong Chen, Yang Zhou, Hongrun Zhou, Yanmin Lv, Lu Zhang, Shan Jin, Shugang Li, Hong Zou, Wei Jia, Cuicui Wang, Jinfang Jiang, Weihua Liang, Lijuan Pang, Feng Li Tags: Original contribution Source Type: research
Evaluation and prognostic significance of manganese superoxide dismutase in clear cell renal cell carcinoma
This study aimed to investigate the expression profile of MnSOD in clear cell RCC (ccRCC) tissues and evaluate the clinical significance of this enzyme in ccRCC patients. MnSOD mRNA was assessed in 42 ccRCC and 33 normal kidney tissues by the Oncomine database, and its protein was detected in 145 ccRCC and 3 normal tissues by immunohistochemistry staining (IHC). (Source: Human Pathology)
Source: Human Pathology - June 20, 2018 Category: Pathology Authors: Zuohui Zhao, Jiaju Lu, Hongyi Qu, Zunsong Wang, Qiang Liu, Xiaoqing Yang, Shuai Liu, Juntao Ge, Yue Xu, Na Li, Yijiao Yuan Tags: Original contribution Source Type: research
High expression of tumor necrosis factor receptor 2 in tissue is associated with progression and prognosis of esophageal squamous cell carcinoma
In this study, we detected TNFR2 expression in ESCC tissues using IHC. The χ2 test showed that TNFR2 was positively correlated with invasion depth, advanced clinical stage and low differentiation; survival analysis showed that TNFR2 was positively correlated with poor OS; univariate Cox regression analysis showed that clinical stage, lymph node involvement and invasion de pth were all correlated with OS; multivariate Cox regression analysis showed that lymph node involvement and invasion depth were independent prognostic factors. (Source: Human Pathology)
Source: Human Pathology - June 16, 2018 Category: Pathology Authors: Zifeng Liu, Changgeng Ma, Guohui Ma, Xiumei Sun, Jin Liu, Shuang Li, Kang Liu, Junye Wang, Dong Yang Tags: Original contribution Source Type: research
