Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma

Synovial sarcoma (SS) is a highly aggressive malignant soft tissue sarcoma with typical characteristics of both epithelial and mesenchymal differentiation. Matrix metalloproteinase-14 (MMP-14) is reported to play an important role in some of these tumors. It induces epithelial-to-mesenchymal transition (EMT) in some carcinomas, such as breast and prostate cancers. However, the role of MMP-14 in the pathogenesis of SS remains unclear. Therefore, we investigated the role of MMP-14 and EMT/mesenchymal-to-epithelial transition (MET) in SS.

Source: Human Pathology - June 20, 2018 Category: Pathology Authors: Manli Liu, Yan Qi, Lili Zhao, Dongdong Chen, Yang Zhou, Hongrun Zhou, Yanmin Lv, Lu Zhang, Shan Jin, Shugang Li, Hong Zou, Wei Jia, Cuicui Wang, Jinfang Jiang, Weihua Liang, Lijuan Pang, Feng Li Tags: Original contribution Source Type: research