Placentas from women with pregnancy-associated venous insufficiency show villi damage with evidence of hypoxic cellular stress
Lower extremity venous insufficiency (VI) is a complication of pregnancy. The potential association of this venous disease with structural damage of the placenta has not been described. We analyzed the pattern of histopathological lesions and the gene and protein expression of HIF1- α and apoptosis regulatory proteins. A prospective study was carried out on placenta samples from 43 women with pregnancy-associated VI and 24 age-matched pregnant healthy controls (HC). Women with VI showed a significant increase in the number of villi (150.77±42.55 VI versus 122.13±27.74 HC) an d in syncytial knots compared to those found ...
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Natalio Garc ía-Honduvilla, Miguel A Ortega, Ángel Asúnsolo, María J Álvarez-Rocha, Beatriz Romero, Juan De León-Luis, Melchor Álvarez- Mon, Julia Buján Tags: Original contribution Source Type: research
Expanding the Histomorphologic Spectrum of TFE3 Rearranged PEComas
Perivascular epithelioid tumors (PEComas) are a family of mesenchymal neoplasms that have smooth muscle and melanocytic differentiation. They can be sporadic or associated with Tuberous Sclerosis Complex and commonly present in the kidney as angiomyolipoma or in the lung as pulmonary clear cell sugar tumors or lymphangioleiomyomatosis. However, they can present at any visceral or soft tissue site. They usually have a benign clinical course, but rarely can behave in a malignant fashion. Most PEComas demonstrate abnormalities of TSC2, but a recently described subset harbor TFE3 rearrangements that appear to be mutually exclu...
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Nolan Maloney, Krinio Giannikou, Joel Lefferts, Julia A. Bridge, Konstantinos Linos Tags: Case study Source Type: research
Masthead
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Source: Human Pathology - April 1, 2018 Category: Pathology Source Type: research
Table of Contents
(Source: Human Pathology)
Source: Human Pathology - April 1, 2018 Category: Pathology Source Type: research
Editorial Board
(Source: Human Pathology)
Source: Human Pathology - April 1, 2018 Category: Pathology Source Type: research
In This Issue
(Source: Human Pathology)
Source: Human Pathology - April 1, 2018 Category: Pathology Source Type: research
Intratumoral and peritumoral lymphovascular invasion detected by D2-40 immunohistochemistry correlates with metastasis in primary cutaneous Merkel cell carcinoma
Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2-40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determine how LVI detected by D2-40 IHC compares with LVI detected by hematoxylin and eosin (H&E) staining in predicting MCC metastasis. Clinical and histopathologic features of MCCs diagnosed and treated in 2002 to 2015 were assembled and included 58 MCC tumors from 58 patients. (Source: Human Pathology)
Source: Human Pathology - March 27, 2018 Category: Pathology Authors: Rami N. Al-Rohil, Den ái R. Milton, Priyadharsini Nagarajan, Jonathan L. Curry, Laurence Feldmeyer, Carlos A. Torres-Cabala, Doina Ivan, Victor G. Prieto, Michael T. Tetzlaff, Phyu P. Aung Tags: Original contribution Source Type: research
Intratumoral Heterogeneity of ERBB2 Amplification and HER2 Expression in Micropapillary Urothelial Carcinoma
Micropapillary urothelial carcinoma (MPUC) is a rare but an aggressive variant of urothelial carcinoma. MPUC has been shown to commonly exhibit ERBB2 amplification and HER2 protein overexpression, but the frequency and distribution of these findings within micropapillary (MP) and not otherwise specified (NOS) components of tumors have not been addressed. Therefore, we evaluated ERBB2 amplification and HER2 expression in 43 MPUC cases by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). (Source: Human Pathology)
Source: Human Pathology - March 27, 2018 Category: Pathology Authors: Sumit Isharwal, Hongying Huang, Gouri Nanjangud, Fran çois Audenet, Ying-Bei Chen, Anuradha Gopalan, Samson W Fine, Satish K Tickoo, Byron H Lee, Gopa Iyer, Kalyani Chadalavada, Jonathan E Rosenberg, Dean F Bajorin, Harry W Herr, S Machele Donat, Guido D Tags: Original contribution Source Type: research
Intratumoral and Peritumoral Lymphovascular Invasion Detected by D2 –40 Immunohistochemistry Correlates with Metastasis in Primary Cutaneous Merkel Cell Carcinoma
Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2 –40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determine how LVI detected by D2–40 IHC compares with LVI detected by hematoxylin–eosin (H&E) staining in predicting MCC metastasis. Clinical and histopathologic features of MCCs diagnosed and treated during 2002 –2015 were assembled and included 58 MCC tumors from 58 patients. (Source: Human Pathology)
Source: Human Pathology - March 27, 2018 Category: Pathology Authors: Rami N. Al-Rohil, Den ái R. Milton, Priyadharsini Nagarajan, Jonathan L. Curry, Laurence Feldmeyer, Carlos A. Torres-Cabala, Doina Ivan, Victor G. Prieto, Michael T. Tetzlaff, Phyu P. Aung Source Type: research
Intratumoral Heterogeneity of ERBB2 Amplification and HER2 Expression in Micropapillary Urothelial Carcinoma
Micropapillary urothelial carcinoma (MPUC) is a rare but an aggressive variant of urothelial carcinoma. MPUC has been shown to commonly exhibit ERBB2 amplification and HER2 protein overexpression, but the frequency and distribution of these findings within micropapillary (MP) and not otherwise specified (NOS) components of tumors have not been addressed. Therefore, we evaluated ERBB2 amplification and HER2 expression in 43 MPUC cases by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). (Source: Human Pathology)
Source: Human Pathology - March 27, 2018 Category: Pathology Authors: Sumit Isharwal, Hongying Huang, Gouri Nanjangud, Fran çois Audenet, Ying-Bei Chen, Anuradha Gopalan, Samson W Fine, Satish K Tickoo, Byron H Lee, Gopa Iyer, Kalyani Chadalavada, Jonathan E Rosenberg, Dean F Bajorin, Harry W Herr, S Machele Donat, Guido D Tags: Original contribution Source Type: research
Intratumoral and Peritumoral Lymphovascular Invasion Detected by D2 –40 Immunohistochemistry Correlates with Metastasis in Primary Cutaneous Merkel Cell Carcinoma
Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2 –40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determine how LVI detected by D2–40 IHC compares with LVI detected by hematoxylin–eosin (H&E) staining in predicting MCC metastasis. Clinical and histopathologic features of MCCs diagnosed and treated during 2002 –2015 were assembled and included 58 MCC tumors from 58 patients. (Source: Human Pathology)
Source: Human Pathology - March 27, 2018 Category: Pathology Authors: Rami N. Al-Rohil, Den ái R. Milton, Priyadharsini Nagarajan, Jonathan L. Curry, Laurence Feldmeyer, Carlos A. Torres-Cabala, Doina Ivan, Victor G. Prieto, Michael T. Tetzlaff, Phyu P. Aung Source Type: research
Microscopic ileitis in diverted and nondiverted enteric segments: an underrecognized condition with a multifactorial etiology
Microscopic ileitis has been infrequently reported in the literature with the few reported cases usually associated with concurrent microscopic colitis. Having encountered a case of collagenous ileitis involving the diverted distal limb of a loop ileostomy and sparing the proximal limb, we examined additional cases of loop ileostomy, end ileostomy, colostomy, and the accompanying diverted colorectal segment for features of microscopic ileitis and colitis. A total of 101 cases of diverted and nondiverted enteric segments were examined from 37 loop ileostomies, 16 end ileostomies, and 12 colostomies status post –Hartmann's...
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Chunlai Zuo, Zhiyan Fu, Edward C. Lee, Llewellyn Foulke, Gloria Q. Young, David Cubero Rego, Hwajeong Lee Tags: Original contribution Source Type: research
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion
Mesenchymal chondrosarcoma is rare and can be challenging to diagnose. Herein, we report a minute mesenchymal chondrosarcoma within an osteochondroma. A 12-year-old girl presented with an asymptomatic exophytic lesion of the rib. The tumor was clinically diagnosed as osteochondroma, and was excised after observation for 3years. The resected specimen revealed an unexpected minute (0.9cm) “monophasic” mesenchymal chondrosarcoma in the apex of the lesion. The sarcoma consisted of monomorphic spindle cells without hyaline cartilage. (Source: Human Pathology)
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Shunichi Toki, Toru Motoi, Mototaka Miyake, Eisuke Kobayashi, Akira Kawai, Akihiko Yoshida Source Type: research
Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma
The tumor microenvironment plays pivotal roles in various human neoplasms. However, that of benign tumor, particularly hormone-secreting endocrine tumors, has remained virtually unknown. Therefore, we firstly attempted to analyze the tumor microenvironment of autonomous hormone-secreting adrenocortical adenomas. We first histologically evaluated 21 cortisol-producing adrenocortical adenoma (CPA) and 13 aldosterone-producing adrenocortical adenoma (APA) cases. Quantitative histological analysis revealed that intratumoral immune cell infiltration (ICI) was more pronounced in CPAs than APAs. (Source: Human Pathology)
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Yuko Kitawaki, Yasuhiro Nakamura, Fumie Kubota-Nakayama, Yuto Yamazaki, Yasuhiro Miki, Shuko Hata, Kazue Ise, Kumi Kikuchi, Ryo Morimoto, Fumitoshi Satoh, Hironobu Sasano Source Type: research
Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3
Pancreatic neuroendocrine carcinoma is a rare aggressive tumor commonly harboring TP53 and RB1 alterations and lacking neuroendocrine related genetic changes such as mutations in MEN1 and ATRX/DAXX. Little is known about its genetic profile with regard to that of pancreatic ductal adenocarcinoma. We therefore conducted a detailed genetic study in 12 pancreatic neuroendocrine carcinomas of large cell (n=9) and small cell type (n=3) using massive parallel sequencing applying a 409 gene panel on an Ion Torrent system. (Source: Human Pathology)
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Bj örn Konukiewitz, Moritz Jesinghaus, Katja Steiger, Anna Melissa Schlitter, Atsuko Kasajima, Bence Sipos, Giuseppe Zamboni, Wilko Weichert, Nicole Pfarr, Günter Klöppel Tags: Original contribution Source Type: research
