Intratumoral and peritumoral lymphovascular invasion detected by D2-40 immunohistochemistry correlates with metastasis in primary cutaneous Merkel cell carcinoma

Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2-40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determine how LVI detected by D2-40 IHC compares with LVI detected by hematoxylin and eosin (H&E) staining in predicting MCC metastasis. Clinical and histopathologic features of MCCs diagnosed and treated in 2002 to 2015 were assembled and included 58 MCC tumors from 58 patients.

https://www.humanpathol.com/article/S0046-8177(18)30094-7/fulltext?rss=yes

Source: Human Pathology - March 27, 2018 Category: Pathology Authors: Rami N. Al-Rohil, Den ái R. Milton, Priyadharsini Nagarajan, Jonathan L. Curry, Laurence Feldmeyer, Carlos A. Torres-Cabala, Doina Ivan, Victor G. Prieto, Michael T. Tetzlaff, Phyu P. Aung Tags: Original contribution Source Type: research