Intratumoral Heterogeneity of ERBB2 Amplification and HER2 Expression in Micropapillary Urothelial Carcinoma

Micropapillary urothelial carcinoma (MPUC) is a rare but an aggressive variant of urothelial carcinoma. MPUC has been shown to commonly exhibit ERBB2 amplification and HER2 protein overexpression, but the frequency and distribution of these findings within micropapillary (MP) and not otherwise specified (NOS) components of tumors have not been addressed. Therefore, we evaluated ERBB2 amplification and HER2 expression in 43 MPUC cases by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC).

http://www.humanpathol.com/article/S0046-8177(18)30092-3/fulltext?rss=yes

Source: Human Pathology - March 27, 2018 Category: Pathology Authors: Sumit Isharwal, Hongying Huang, Gouri Nanjangud, Fran çois Audenet, Ying-Bei Chen, Anuradha Gopalan, Samson W Fine, Satish K Tickoo, Byron H Lee, Gopa Iyer, Kalyani Chadalavada, Jonathan E Rosenberg, Dean F Bajorin, Harry W Herr, S Machele Donat, Guido D Tags: Original contribution Source Type: research