Microscopic ileitis in diverted and non-diverted enteric segments: an under-recognized condition with a multifactorial etiology
Microscopic ileitis has been infrequently reported in the literature with the few reported cases usually associated with concurrent microscopic colitis. Having encountered a case of collagenous ileitis involving the diverted distal limb of a loop ileostomy and sparing the proximal limb, we examined additional cases of loop ileostomy, end ileostomy, colostomy, and the accompanying diverted colorectal segment for features of microscopic ileitis and colitis. A total of 101 cases of diverted and non-diverted enteric segments were examined from 37 loop ileostomies, 16 end ileostomies and 12 colostomies status post Hartmann's pr...
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Chunlai Zuo, Zhiyan Fu, Edward C. Lee, Llewellyn Foulke, Gloria Q. Young, David Cubero Rego, Hwajeong Lee Tags: Original contribution Source Type: research
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion
Mesenchymal chondrosarcoma is rare and can be challenging to diagnose. Herein, we report a minute mesenchymal chondrosarcoma within an osteochondroma. A 12-year-old girl presented with an asymptomatic exophytic lesion of the rib. The tumor was clinically diagnosed as osteochondroma, and was excised after observation for 3years. The resected specimen revealed an unexpected minute (0.9cm) “monophasic” mesenchymal chondrosarcoma in the apex of the lesion. The sarcoma consisted of monomorphic spindle cells without hyaline cartilage. (Source: Human Pathology)
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Shunichi Toki, Toru Motoi, Mototaka Miyake, Eisuke Kobayashi, Akira Kawai, Akihiko Yoshida Source Type: research
Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma
The tumor microenvironment plays pivotal roles in various human neoplasms. However, that of benign tumor, particularly hormone-secreting endocrine tumors, has remained virtually unknown. Therefore, we firstly attempted to analyze the tumor microenvironment of autonomous hormone-secreting adrenocortical adenomas. We first histologically evaluated 21 cortisol-producing adrenocortical adenoma (CPA) and 13 aldosterone-producing adrenocortical adenoma (APA) cases. Quantitative histological analysis revealed that intratumoral immune cell infiltration (ICI) was more pronounced in CPAs than APAs. (Source: Human Pathology)
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Yuko Kitawaki, Yasuhiro Nakamura, Fumie Kubota-Nakayama, Yuto Yamazaki, Yasuhiro Miki, Shuko Hata, Kazue Ise, Kumi Kikuchi, Ryo Morimoto, Fumitoshi Satoh, Hironobu Sasano Source Type: research
Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3
Pancreatic neuroendocrine carcinoma is a rare aggressive tumor commonly harboring TP53 and RB1 alterations and lacking neuroendocrine related genetic changes such as mutations in MEN1 and ATRX/DAXX. Little is known about its genetic profile with regard to that of pancreatic ductal adenocarcinoma. We therefore conducted a detailed genetic study in 12 pancreatic neuroendocrine carcinomas of large cell (n=9) and small cell type (n=3) using massive parallel sequencing applying a 409 gene panel on an Ion Torrent system. (Source: Human Pathology)
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Bj örn Konukiewitz, Moritz Jesinghaus, Katja Steiger, Anna Melissa Schlitter, Atsuko Kasajima, Bence Sipos, Giuseppe Zamboni, Wilko Weichert, Nicole Pfarr, Günter Klöppel Tags: Original contribution Source Type: research
Microscopic ileitis in diverted and non-diverted enteric segments: an under-recognized condition with a multifactorial etiology
Microscopic ileitis has been infrequently reported in the literature with the few reported cases usually associated with concurrent microscopic colitis. Having encountered a case of collagenous ileitis involving the diverted distal limb of a loop ileostomy and sparing the proximal limb, we examined additional cases of loop ileostomy, end ileostomy, colostomy, and the accompanying diverted colorectal segment for features of microscopic ileitis and colitis. A total of 101 cases of diverted and non-diverted enteric segments were examined from 37 loop ileostomies, 16 end ileostomies and 12 colostomies status post Hartmann's pr...
Source: Human Pathology - March 26, 2018 Category: Pathology Authors: Chunlai Zuo, Zhiyan Fu, Edward C. Lee, Llewellyn Foulke, Gloria Q. Young, David Cubero Rego, Hwajeong Lee Tags: Original contribution Source Type: research
A 4-microRNA signature predicts lymph node metastasis and prognosis in breast cancer
Recent findings have reported that human microRNAs (miRNAs) could serve as prognostic biomarkers in various cancers. We aimed to identify miRNAs that were associated with lymph node metastasis (LNM) and prognosis in breast cancer patients. A miRNA microarray covering 2019 mature miRNAs was used to identify differentially expressed miRNAs in 9 patients with LNM and 3 patients without LNM. Thirty-five differentially expressed miRNAs were identified, of which 10 significantly were up-regulated, whereas the other 25 were down-regulated in tissues with LNM compared with those without LNM. (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Xu Chen, Ya-Wen Wang, Wen-Jie Zhu, Yan Li, Lin Liu, Gang Yin, Peng Gao Tags: Original contribution Source Type: research
Whole-exome sequencing identified mutational profiles of squamous cell carcinomas of anus
Anal squamous cell carcinoma (ASCC), either with human papillomavirus (HPV) (+) or ( −), is a neoplastic disease with frequent recurrence and metastasis. To characterize ASCC genomes, we attempted to disclose novel alterations of ASCC genomes as well as other genetic features including mutation signatures. We performed whole-exome sequencing and copy number alteration (CNA) profil ing for 8 ASCC samples from 6 patients (2 cases with primary and recurrent/metastatic tumors). We found known ASCC mutations (TP53, CDKN2A and PIK3CA) and CNAs (gains on 3q and 19q and losses on 11q and 13q). (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Sun Shin, Hyeon-Chun Park, Min Sung Kim, Mi-Ryung Han, Sung Hak Lee, Seung Hyun Jung, Sug Hyung Lee, Yeun-Jun Chung Source Type: research
Routine histologic features in complex atypical hyperplasia can predict the presence of endometrial carcinoma: a clinicopathologic study of 222 cases
There is a wide range of finding endometrial adenocarcinoma (ADCA) in the uterus following a diagnosis of complex atypical hyperplasia (CAH), likely due to a poor diagnostic reproducibility and an inherent heterogeneity in CAH. We evaluated whether histologic subtyping of CAH would help predict ADCA. Our study consisted of 222 cases of CAH diagnosed by endometrial biopsy or curettage. ADCA was seen in 38.3% of these cases at hysterectomy. We divided CAH into two subtypes: type A was defined as back-to-back glands in a focus smaller than 2.1 mm, and type B as crowded glands with cytologic atypia but there was still interven...
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Cunxian Zhang, Edmond Y Wang, Fang Liu, C James Sung, M Ruhul Quddus, Joyce Ou, Michele Lomme, W Dwayne Lawrence Tags: Original Contribution Source Type: research
A four-microRNA signature predicts lymph node metastasis and prognosis in breast cancer
Recent findings have reported that human microRNAs (miRNAs) could serve as prognostic biomarkers in various cancers. We aimed to identify miRNAs that were associated with lymph node metastasis (LNM) and prognosis in breast cancer patients. A miRNA microarray covering 2019 mature miRNAs was used to identify differentially-expressed miRNAs in nine patients with LNM and three patients without LNM. Thirty-five differentially expressed miRNAs were identified, of which 10 significantly were up-regulated while the other 25 were down-regulated in tissues with LNM compared to those without LNM. (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Xu Chen, Ya-Wen Wang, Wen-Jie Zhu, Yan Li, Lin Liu, Gang Yin, Peng Gao Source Type: research
Mesenchymal Chondrosarcomas Showing Immunohistochemical Evidence of Rhabdomyoblastic Differentiation: A Potential Diagnostic Pitfall
The diagnosis of mesenchymal chondrosarcoma, a distinctive biphasic malignant neoplasm harboring the HEY1-NCOA2 gene fusion and consisting of primitive round to spindled cells admixed with foci of relatively mature hyaline cartilage, is usually straightforward by morphological evaluation alone. However, in the setting of a limited biopsy, specimens lacking cartilage generate a broad differential diagnosis, encompassing a variety of other primitive sarcomas, including spindle cell/ sclerosing rhabdomyosarcoma. (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Andrew L. Folpe, Rondell P. Graham, Anthony Martinez, David Schembri-Wismayer, Jennifer Boland, Karen J. Fritchie Tags: Original Contribution Source Type: research
ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma
Acyl-CoA thioesterase 1 (ACOT1) is an important isoform of the ACOT family that catalyzes the reaction of fatty acyl-CoAs to CoA-SH and free fatty acids. Recent studies of gastrointestinal tumor metabolism suggest that there is abnormal metabolism of lipids and fatty acids during tumor progression. However, the function and contribution of ACOT1 in gastric cancer development are still poorly understood. Additionally, GLI3 is a major transcription factor in the regulation of hedgehog (Hh) signaling. (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Fang Wang, Jingyi Wu, Zhichao Qiu, Xiaosong Ge, Xingxiang Liu, Chun Zhang, Wenhuan Xu, Fengming Wang, Dong Hua, Xiaowei Qi, Yong Mao Tags: Original contribution Source Type: research
Whole-exome sequencing identified mutational profiles of squamous cell carcinomas of anus
Anal squamous cell carcinoma (ASCC), either with human papillomavirus (HPV) (+) or ( −), is a neoplastic disease with frequent recurrence and metastasis. To characterize ASCC genomes, we attempted to disclose novel alterations of ASCC genomes as well as other genetic features including mutation signatures. We performed whole-exome sequencing and copy number alteration (CNA) profil ing for 8 ASCC samples from 6 patients (2 cases with primary and recurrent/metastatic tumors). We found known ASCC mutations (TP53, CDKN2A and PIK3CA) and CNAs (gains on 3q and 19q and losses on 11q and 13q). (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Sun Shin, Hyeon-Chun Park, Min Sung Kim, Mi-Ryung Han, Sung Hak Lee, Seung Hyun Jung, Sug Hyung Lee, Yeun-Jun Chung Source Type: research
Routine histologic features in complex atypical hyperplasia can predict the presence of endometrial carcinoma: a clinicopathologic study of 222 cases
There is a wide range of finding endometrial adenocarcinoma (ADCA) in the uterus following a diagnosis of complex atypical hyperplasia (CAH), likely due to a poor diagnostic reproducibility and an inherent heterogeneity in CAH. We evaluated whether histologic subtyping of CAH would help predict ADCA. Our study consisted of 222 cases of CAH diagnosed by endometrial biopsy or curettage. ADCA was seen in 38.3% of these cases at hysterectomy. We divided CAH into two subtypes: type A was defined as back-to-back glands in a focus smaller than 2.1 mm, and type B as crowded glands with cytologic atypia but there was still interven...
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Cunxian Zhang, Edmond Y Wang, Fang Liu, C James Sung, M Ruhul Quddus, Joyce Ou, Michele Lomme, W Dwayne Lawrence Tags: Original Contribution Source Type: research
A four-microRNA signature predicts lymph node metastasis and prognosis in breast cancer
Recent findings have reported that human microRNAs (miRNAs) could serve as prognostic biomarkers in various cancers. We aimed to identify miRNAs that were associated with lymph node metastasis (LNM) and prognosis in breast cancer patients. A miRNA microarray covering 2019 mature miRNAs was used to identify differentially-expressed miRNAs in nine patients with LNM and three patients without LNM. Thirty-five differentially expressed miRNAs were identified, of which 10 significantly were up-regulated while the other 25 were down-regulated in tissues with LNM compared to those without LNM. (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Xu Chen, Ya-Wen Wang, Wen-Jie Zhu, Yan Li, Lin Liu, Gang Yin, Peng Gao Source Type: research
Mesenchymal Chondrosarcomas Showing Immunohistochemical Evidence of Rhabdomyoblastic Differentiation: A Potential Diagnostic Pitfall
The diagnosis of mesenchymal chondrosarcoma, a distinctive biphasic malignant neoplasm harboring the HEY1-NCOA2 gene fusion and consisting of primitive round to spindled cells admixed with foci of relatively mature hyaline cartilage, is usually straightforward by morphological evaluation alone. However, in the setting of a limited biopsy, specimens lacking cartilage generate a broad differential diagnosis, encompassing a variety of other primitive sarcomas, including spindle cell/ sclerosing rhabdomyosarcoma. (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Andrew L. Folpe, Rondell P. Graham, Anthony Martinez, David Schembri-Wismayer, Jennifer Boland, Karen J. Fritchie Tags: Original Contribution Source Type: research
