Initial experience in single-incision transumbilical laparoscopic liver resection: indications, potential benefits, and limitations.
Conclusion. SITLLR remains a challenging procedure. It is feasible in highly selected patients, requiring experience in hepatobiliary and laparoscopic surgery and skills in single-incision laparoscopy. Apart from cosmetic benefit, our experience and literature review did not show significant advantages if compared with multiport LLR, underlying that specific indications remain to be established.
PMID: 23082044 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy.
Conclusions. Neither MICA nor DEPDC5 genetic polymorphism correlates with HCC recurrence following hepatectomy. DEPDC5 minor genotype data suggest a high susceptibility for HCC development in livers, even those with low fibrosis stages.
PMID: 23132957 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Contemporary strategies in the management of hepatocellular carcinoma.
Authors: Khorsandi SE, Heaton N
Abstract
Liver transplantation is the treatment of choice for selected patients with hepatocellular carcinoma (HCC) on a background of chronic liver disease. Liver resection or locoregional ablative therapies may be indicated for patients with preserved synthetic function without significant portal hypertension. Milan criteria were introduced to select suitable patients for liver transplant with low risk of tumor recurrence and 5-year survival in excess of 70%. Currently the incidence of HCC is climbing rapidly and in a current climate of organ shortage has led to the re-eva...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Bleeding in Hepatic Surgery: Sorting through Methods to Prevent It.
Authors: Romano F, Garancini M, Uggeri F, Degrate L, Nespoli L, Gianotti L, Nespoli A, Uggeri F
Abstract
Liver resections are demanding operations which can have life threatening complications although they are performed by experienced liver surgeons. The parameter "Blood Loss" has a central role in liver surgery, and different strategies to minimize it are a key to improve results. Moreover, recently, new technologies are applied in the field of liver surgery, having one goal: safer and easier liver operations. The aim of this paper is to review the different principal solutions to the problem of blood lo...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Ischemia/Reperfusion injury in liver surgery and transplantation.
Authors: Schemmer P, Lemasters JJ, Clavien PA
PMID: 23345924 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Living-donor liver transplantation and hepatitis C.
Authors: Akamatsu N, Sugawara Y
Abstract
Hepatitis-C-virus- (HCV-) related end-stage cirrhosis is the primary indication for liver transplantation in many countries. Unfortunately, however, HCV is not eliminated by transplantation and graft reinfection is universal, resulting in fibrosis, cirrhosis, and finally graft decompression. In areas with low deceased-donor organ availability like Japan, living-donor liver transplantation (LDLT) is similarly indicated for HCV cirrhosis as deceased-donor liver transplantation (DDLT) in Western countries and accepted as an established treatment for HCV-cirrhosis, and ...
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Innovative strategies and recent advances in liver surgery.
Authors: Lauterio A, Popescu I, García-Valdecasas JC, De Carlis L
PMID: 23606788 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Technical note: facilitating laparoscopic liver biopsy by the use of a single-handed disposable core biopsy needle.
We report a technique of laparoscopic liver biopsy using a disposable core biopsy instrument (BARD (R) disposable core biopsy needle) that can be used single-handedly. The needle can be positioned with laparoscopic graspers in order to reach posterior and superior lesions. This technique can easily be used in conjunction with laparoscopic ultrasound.
PMID: 23690654 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience.
Conclusion. Our data support that one still, and perhaps to an even greater extent, should seek an aggressive therapeutic strategy to achieve resectable status for recurrent hepatic and extrahepatic metastases. The data should be viewed in the context of recent advances in the understanding of cancer biology and the metastatic process.
PMID: 23840074 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Prognostic impact of preoperative imaging parameters on resectability of hilar cholangiocarcinoma.
Conclusions. Current staging systems predict resectability, but there is room for improvement. Hepatic artery involvement and nodal status might be important factors for prediction of resectability and should be considered in future staging systems.
PMID: 23861556 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
An evaluation of neoadjuvant chemoradiotherapy for patients with resectable pancreatic ductal adenocarcinoma.
Conclusions. The treatment of NCRT followed by PD in patients with PDAC has a significantly lower rate of locoregional recurrence and a longer overall survival than those with surgery alone.
PMID: 23864756 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
MDCT Imaging Findings of Liver Cirrhosis: Spectrum of Hepatic and Extrahepatic Abdominal Complications.
The objective of this paper is to illustrate the imaging spectrum of intra- and extrahepatic abdominal manifestations of hepatic cirrhosis seen on MDCT.
PMID: 23986608 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
The Preoperative Assessment of Hepatic Tumours: Evaluation of UK Regional Multidisciplinary Team Performance.
Discussion. MDT assessment of patients preoperatively is accurate in terms of diagnosis. The highest rate of discrepancies occurred in patients with focal lesions without chronic liver disease or primary cancer, where hepatocellular carcinoma was overdiagnosed and peripheral cholangiocarcinoma underdiagnosed, where particular care should be taken. Additional care should be taken in these groups and preoperative multimodality imaging considered.
PMID: 24062601 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury.
Conclusion. PTX infusion was associated with hemodynamic benefits and was able to minimize liver injury during normothermic hepatic I/R. However, local PTX infusion was not associated with any significant advantage over systemic route.
PMID: 24072955 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
A randomized clinical trial comparing the effect of different haemostatic agents for haemostasis of the liver after hepatic resection.
Conclusion. Due to higher complications in Surgicel group, its application as hemostatic agent after liver resection is not recommended. Better results in TachoSil in comparison to the other two are indicative of its better efficacy and superiority in controlling hemostasis.
PMID: 24159254 [PubMed] (Source: HPB Surgery)
Source: HPB Surgery - October 29, 2015 Category: Surgery Tags: HPB Surg Source Type: research
